Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases.

Autor: Alenezi WM; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC, Canada.; Department of Medical Laboratory Technology, Taibah University, Medina, Saudi Arabia., Fierheller CT; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC, Canada., Serruya C; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC, Canada., Revil T; Department of Human Genetics, McGill University, Montreal, QC, Canada.; McGill Genome Centre, McGill University, Montreal, QC, Canada., Oros KK; Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC, Canada., Subramanian DN; Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Bruce J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Spiegelman D; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Pugh T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Campbell IG; Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Mes-Masson AM; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, QC, Canada.; Departement of Medicine, Université de Montréal, Montreal, QC, Canada., Provencher D; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, QC, Canada.; Division of Gynecologic Oncology, Université de Montréal, Montreal, QC, Canada., Foulkes WD; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC, Canada.; Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC, Canada.; Department of Medical Genetics, McGill University Health Centre, Montreal, QC, Canada.; Department of Medicine, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada., Haffaf ZE; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, QC, Canada.; Service de Médecine Génique, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada., Rouleau G; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Bouchard L; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada.; Department of Medical Biology, Centres intégrés universitaires de santé et de services sociaux du Saguenay-Lac-Saint-Jean hôpital Universitaire de Chicoutimi, Saguenay, QC, Canada.; Centre de Recherche du Centre hospitalier l'Université de Sherbrooke, Sherbrooke, QC, Canada., Greenwood CMT; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada., Ragoussis J; Department of Human Genetics, McGill University, Montreal, QC, Canada.; McGill Genome Centre, McGill University, Montreal, QC, Canada., Tonin PN; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC, Canada.; Department of Medicine, McGill University, Montreal, QC, Canada.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Mar 08; Vol. 13, pp. 1111191. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023).

The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population.

Autor: Alenezi WM; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada.; Department of Medical Laboratory Technology, Taibah University, Medina 42353, Saudi Arabia., Milano L; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, QC G1V0A6, Canada.; Genome Stability Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Québec, HDQ Pavilion, Oncology Axis, Quebec City, QC G1R2J6, Canada., Fierheller CT; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada., Serruya C; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada., Revil T; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; McGill Genome Centre, McGill University, Montreal, QC H3A0G1, Canada., Oros KK; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T1E2, Canada., Behl S; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada., Arcand SL; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada., Nayar P; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada.; Institute of Parasitology, McGill University, Montreal, QC H9X3V9, Canada., Spiegelman D; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Montreal Neurological Institute, McGill University, Montreal, QC H3A2B4, Canada., Gravel S; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; McGill Genome Centre, McGill University, Montreal, QC H3A0G1, Canada., Mes-Masson AM; Institut du Cancer de Montréal, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X0A9, Canada.; Département de Médecine, Université de Montréal, Montreal, QC H3T1J4, Canada., Provencher D; Institut du Cancer de Montréal, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X0A9, Canada.; Division of Gynecologic Oncology, Université de Montréal, Montreal, QC H4A3J1, Canada., Foulkes WD; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T1E2, Canada.; Department of Medical Genetics, McGill University Health Centre, Montreal, QC H4A3J1, Canada.; Department of Medicine, McGill University, Montreal, QC H3G2M1, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3A1G5, Canada., El Haffaf Z; Institut du Cancer de Montréal, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X0A9, Canada.; Service de Médecine Geénique, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X0A9, Canada., Rouleau G; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Montreal Neurological Institute, McGill University, Montreal, QC H3A2B4, Canada., Bouchard L; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC J1K2R1, Canada.; Department of Medical Biology, Centres Intégrés Universitaires de Santé et de Services Sociaux du Saguenay-Lac-Saint-Jean Hôpital Universitaire de Chicoutimi, Saguenay, QC G7H7K9, Canada.; Centre de Recherche du Centre Hospitalier l'Université de Sherbrooke, Sherbrooke, QC J1H5N4, Canada., Greenwood CMT; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T1E2, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3A1G5, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A1A2, Canada., Masson JY; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, QC G1V0A6, Canada.; Genome Stability Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Québec, HDQ Pavilion, Oncology Axis, Quebec City, QC G1R2J6, Canada., Ragoussis J; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; McGill Genome Centre, McGill University, Montreal, QC H3A0G1, Canada., Tonin PN; Department of Human Genetics, McGill University, Montreal, QC H3A0C7, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A3J1, Canada.; Department of Medicine, McGill University, Montreal, QC H3G2M1, Canada.

Publikováno v: Cancers [Cancers (Basel)] 2022 Apr 30; Vol. 14 (9). Date of Electronic Publication: 2022 Apr 30.

A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene.

Autor: Fierheller CT; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3 J1, Canada., Guitton-Sert L; Genome Stability Laboratory, CHU de Québec-Université Laval Research Center, Oncology Division, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec City, Quebec, Canada., Alenezi WM; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3 J1, Canada.; Department of Medical Laboratory Technology, Taibah University, Medina, Saudi Arabia., Revil T; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; McGill Genome Centre, McGill University, Montreal, Quebec, Canada., Oros KK; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada., Gao Y; Genome Stability Laboratory, CHU de Québec-Université Laval Research Center, Oncology Division, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec City, Quebec, Canada., Bedard K; Laboratoire de Diagnostic Moléculaire, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada.; Département de pathologie et biologie cellulaire, Université de Montréal, Montreal, Quebec, Canada., Arcand SL; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3 J1, Canada., Serruya C; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3 J1, Canada., Behl S; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Meunier L; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, Quebec, Canada., Fleury H; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, Quebec, Canada., Fewings E; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK., Subramanian DN; Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Nadaf J; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; McGill Genome Centre, McGill University, Montreal, Quebec, Canada., Bruce JP; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Bell R; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Provencher D; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, Quebec, Canada.; Division of Gynecologic Oncology, Université de Montréal, Montreal, Quebec, Canada., Foulkes WD; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3 J1, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Department of Medicine, McGill University, Montreal, Quebec, Canada., El Haffaf Z; Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada., Mes-Masson AM; Centre de recherche du Centre hospitalier de l'Université de Montréal and Institut du cancer de Montréal, Montreal, Quebec, Canada.; Department of Medicine, Université de Montréal, Montreal, Quebec, Canada., Majewski J; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Tischkowitz M; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK., James PA; Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; The Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia., Campbell IG; Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Greenwood CMT; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Quebec, Canada., Ragoussis J; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; McGill Genome Centre, McGill University, Montreal, Quebec, Canada., Masson JY; Genome Stability Laboratory, CHU de Québec-Université Laval Research Center, Oncology Division, Quebec City, Quebec, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec City, Quebec, Canada., Tonin PN; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. patricia.tonin@mcgill.ca.; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3 J1, Canada. patricia.tonin@mcgill.ca.; Department of Medicine, McGill University, Montreal, Quebec, Canada. patricia.tonin@mcgill.ca.

Publikováno v: Genome medicine [Genome Med] 2021 Dec 03; Vol. 13 (1), pp. 186. Date of Electronic Publication: 2021 Dec 03.

Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers.

Autor: Alenezi WM; Department of Human Genetics, McGill University, Montreal, QC H3A 0G4, Canada.; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Department of Medical Laboratory Technology, Taibah University, Medina 42353, Saudi Arabia., Fierheller CT; Department of Human Genetics, McGill University, Montreal, QC H3A 0G4, Canada.; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Recio N; Department of Human Genetics, McGill University, Montreal, QC H3A 0G4, Canada.; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Tonin PN; Department of Human Genetics, McGill University, Montreal, QC H3A 0G4, Canada.; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Department of Medicine, McGill University, Montreal, QC H3A 0G4, Canada.

Publikováno v: Genes [Genes (Basel)] 2020 Jul 27; Vol. 11 (8). Date of Electronic Publication: 2020 Jul 27.