Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Alena Zíková"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0012007 (2024)
Trypanosoma brucei is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs. They rely on A
Externí odkaz:
https://doaj.org/article/80c616d10ccd4ebb9a94e244ed85dd6a
Autor:
Gergana Taleva, Michaela Husová, Brian Panicucci, Carolina Hierro-Yap, Erika Pineda, Marc Biran, Martin Moos, Petr Šimek, Falk Butter, Frédéric Bringaud, Alena Zíková
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011699 (2023)
The long slender bloodstream form Trypanosoma brucei maintains its essential mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1-ATP synthase operating in the reverse mode. The ATP that drives this hydrolytic reac
Externí odkaz:
https://doaj.org/article/4dc3c4c623334b23bad5e9817194ed8a
Autor:
Ondřej Gahura, Alexander Mühleip, Carolina Hierro-Yap, Brian Panicucci, Minal Jain, David Hollaus, Martina Slapničková, Alena Zíková, Alexey Amunts
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Mitochondrial ATP synthase assemble into oligomers. Here, authors resolve the structure of trypanosomal ATP synthase, showing that its dimerization is essential for function and evolutionary conserved.
Externí odkaz:
https://doaj.org/article/033e79272bfa4cdc9ca0a33a7abdda7a
Autor:
Eva Doleželová, Tomáš Klejch, Petr Špaček, Martina Slapničková, Luke Guddat, Dana Hocková, Alena Zíková
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-27 (2021)
Abstract All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation. Therefore, purine derivatives have been considered as a promising so
Externí odkaz:
https://doaj.org/article/7fb8cd7b12b54150b152a5cdc8ad9e6f
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
Externí odkaz:
https://doaj.org/article/1767f7b4bbeb4b76aa8d1727845ef2e7
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
Mitochondria have undergone profound diversification in separate lineages that have radiated since the last common ancestor of eukaryotes some eons ago. Most eukaryotes are unicellular protists, including etiological agents of infectious diseases, li
Externí odkaz:
https://doaj.org/article/4bba14266b574b45ad234ef8110561a5
Autor:
Oriana Villafraz, Marc Biran, Erika Pineda, Nicolas Plazolles, Edern Cahoreau, Rodolpho Ornitz Oliveira Souza, Magali Thonnus, Stefan Allmann, Emmanuel Tetaud, Loïc Rivière, Ariel M Silber, Michael P Barrett, Alena Zíková, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009204 (2021)
Trypanosoma brucei, a protist responsible for human African trypanosomiasis (sleeping sickness), is transmitted by the tsetse fly where the procyclic forms of the parasite develop in the proline-rich (1-2 mM) and glucose-depleted digestive tract. Pro
Externí odkaz:
https://doaj.org/article/1885a736cc92490ba8841d001d3da10c
Autor:
Eva Doleželová, Michaela Kunzová, Mario Dejung, Michal Levin, Brian Panicucci, Clément Regnault, Christian J Janzen, Michael P Barrett, Falk Butter, Alena Zíková
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000741 (2020)
Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle because the insect stage utilizes a cost-effective oxidative phosphorylation (OxPhos) to generate ATP, while bloodstream cells switch to aerobic glycolysi
Externí odkaz:
https://doaj.org/article/a36779139e0b4aaaba1556403084e023
Autor:
Anna Nenarokova, Kristína Záhonová, Marija Krasilnikova, Ondřej Gahura, Richard McCulloch, Alena Zíková, Vyacheslav Yurchenko, Julius Lukeš
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT We report frequent losses of components of the classical nonhomologous end joining pathway (C-NHEJ), one of the main eukaryotic tools for end joining repair of DNA double-strand breaks, in several lineages of parasitic protists. Moreover, we
Externí odkaz:
https://doaj.org/article/654d7dbb7b3644f2bb0e34c89954906e
Autor:
Abdulsalam A.M. Alkhaldi, Jan Martinek, Brian Panicucci, Christophe Dardonville, Alena Zíková, Harry P. de Koning
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 1, Pp 23-34 (2016)
Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently under investigation. As part of their preclinical evaluation we here report on their mode of action against African trypanosomes, the etiological agents of sle
Externí odkaz:
https://doaj.org/article/a17e1033e2da40fa8d914ae25dd75abf