Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alena Svobodova Kovarikova"'
Autor:
Petra Vychytilova-Faltejskova, Alena Svobodova Kovarikova, Tomas Grolich, Vladimir Prochazka, Katerina Slaba, Tana Machackova, Jana Halamkova, Marek Svoboda, Zdenek Kala, Igor Kiss, Ondrej Slaby
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4460 (2019)
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Each step of their production and maturation has to be strictly regulated, as any disruption of control mechanisms may lead to cancer. Thus, we have me
Externí odkaz:
https://doaj.org/article/b01ea035d464473fb22dd2c0bfbb334e
Akademický článek
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Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-17 (2023)
Abstract RNA modifications have been known for many years, but their function has not been fully elucidated yet. For instance, the regulatory role of acetylation on N4-cytidine (ac4C) in RNA can be explored not only in terms of RNA stability and mRNA
Externí odkaz:
https://doaj.org/article/dccaeeca540a4a2c888d0ed8fb9e00cf
Autor:
Soňa Legartová, Alena Svobodová Kovaříková, Jana Běhalová Suchánková, Hana Polášek-Sedláčková, Eva Bártová
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 1153-1171 (2022)
RNA methylation, especially 6-methyladenosine (m6A)-modified RNAs, plays a specific role in DNA damage response (DDR). Here, we also observe that RNA modified at 8-methyladenosine (m8A) is recruited to UVA-damaged chromatin immediately after microirr
Externí odkaz:
https://doaj.org/article/57202bccd64143ef8845697dfaf2ada0
Publikováno v:
Life, Vol 11, Iss 7, p 669 (2021)
METTL16 methyltransferase is responsible for the methylation of N6-adenosine (m6A) in several RNAs. In mouse cells, we showed that the nuclear distribution of METTL16 is cell cycle-specific. In the G1/S phases, METTL16 accumulates to the nucleolus, w
Externí odkaz:
https://doaj.org/article/23039bf3561b4c57b5109e6b130020d4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1995 (2021)
G-quadruplexes (G4s) are four-stranded helical structures that regulate several nuclear processes, including gene expression and telomere maintenance. We observed that G4s are located in GC-rich (euchromatin) regions and outside the fibrillarin-posit
Externí odkaz:
https://doaj.org/article/104133a013634b7a9e7681f68e9cfc4c
Autor:
Alena Svobodová Kovaříková, Lenka Stixová, Aleš Kovařík, Denisa Komůrková, Soňa Legartová, Paolo Fagherazzi, Eva Bártová
Publikováno v:
Cells, Vol 9, Iss 2, p 360 (2020)
The DNA damage response is mediated by both DNA repair proteins and epigenetic markers. Here, we observe that N6-methyladenosine (m6A), a mark of the epitranscriptome, was common in RNAs accumulated at UV-damaged chromatin; however, inhibitors of RNA
Externí odkaz:
https://doaj.org/article/0f0ff6109b3c4db9b21e76b0ad6363a6