Výsledky vyhledávání - "Alena Rudkouskaya"

Akademický článek

In vivo quantitative FRET small animal imaging: Intensity versus lifetime-based FRET

Autor: Jason T. Smith, Nattawut Sinsuebphon, Alena Rudkouskaya, Xavier Michalet, Xavier Intes, Margarida Barroso

Publikováno v: Biophysical Reports, Vol 3, Iss 2, Pp 100110- (2023)

Förster resonance energy transfer (FRET) microscopy is used in numerous biophysical and biomedical applications to monitor inter- and intramolecular interactions and conformational changes in the 2–10 nm range. FRET is currently being extended to

Externí odkaz: https://doaj.org/article/486493d5dfb4401590016c5eb4302e57

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Akademický článek

Quantitative label-free imaging of iron-bound transferrin in breast cancer cells and tumors

Autor: Ting Chean Khoo, Kate Tubbesing, Alena Rudkouskaya, Shilpi Rajoria, Anna Sharikova, Margarida Barroso, Alexander Khmaladze

Publikováno v: Redox Biology, Vol 36, Iss , Pp 101617- (2020)

Transferrin (Tf) is an essential serum protein which delivers iron throughout the body via transferrin-receptor (TfR)-mediated uptake and iron release in early endosomes. Currently, there is no robust method to assay the population of iron-bound Tf i

Externí odkaz: https://doaj.org/article/23b09dbf80ca4d1a8047b77f61c511f7

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Akademický článek

Quantification of Trastuzumab–HER2 Engagement In Vitro and In Vivo

Autor: Alena Rudkouskaya, Jason T. Smith, Xavier Intes, Margarida Barroso

Publikováno v: Molecules, Vol 25, Iss 24, p 5976 (2020)

Human EGF Receptor 2 (HER2) is an important oncogene driving aggressive metastatic growth in up to 20% of breast cancer tumors. At the same time, it presents a target for passive immunotherapy such as trastuzumab (TZM). Although TZM has been widely u

Externí odkaz: https://doaj.org/article/0518cb86fd3d42469f5049c05d5a9922

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Akademický článek

Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling.

Autor: David Judah, Alena Rudkouskaya, Ryan Wilson, David E Carter, Lina Dagnino

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36704 (2012)

Integrin-linked kinase (ILK) is an important scaffold protein that mediates a variety of cellular responses to integrin stimulation by extracellular matrix proteins. Mice with epidermis-restricted inactivation of the Ilk gene exhibit pleiotropic phen

Externí odkaz: https://doaj.org/article/ad23e5a78db540dbbb725b71474aeb0d

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Akademický článek

Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation.

Autor: Iskandar F Abdullaev, Alena Rudkouskaya, Alexander A Mongin, Yu-Hung Kuo

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12304 (2010)

Gliomas are morbid brain tumors that are extremely resistant to available chemotherapy and radiology treatments. Some studies have suggested that calcium-activated potassium channels contribute to the high proliferative potential of tumor cells, incl

Externí odkaz: https://doaj.org/article/a5b8fc2c5c7444e0bbbef7d4d1dcf332

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Akademický článek

Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo.

Autor: Renée E Haskew-Layton, Alena Rudkouskaya, Yiqiang Jin, Paul J Feustel, Harold K Kimelberg, Alexander A Mongin

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3543 (2008)

A variety of physiological and pathological factors induce cellular swelling in the brain. Changes in cell volume activate several types of ion channels, which mediate the release of inorganic and organic osmolytes and allow for compensatory cell vol

Externí odkaz: https://doaj.org/article/3a691a43cc8f4a1b8e100026690892bf

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