Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alena Paleskava"'
Autor:
Pavel V. Panteleev, Eugene B. Pichkur, Roman N. Kruglikov, Alena Paleskava, Olga V. Shulenina, Ilia A. Bolosov, Ivan V. Bogdanov, Victoria N. Safronova, Sergey V. Balandin, Valeriya I. Marina, Tatiana I. Kombarova, Olga V. Korobova, Olga V. Shamova, Alexander G. Myasnikov, Alexander I. Borzilov, Ilya A. Osterman, Petr V. Sergiev, Alexey A. Bogdanov, Olga A. Dontsova, Andrey L. Konevega, Tatiana V. Ovchinnikova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The antimicrobial resistance crisis along with challenges of antimicrobial discovery revealed the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial peptides (PrAMPs) inhibit the process of bacterial tr
Externí odkaz:
https://doaj.org/article/9de33db467d84874bde0aeaf8143a9ce
Autor:
Roman A. Bontsevich, Tatiana I. Balamutova, Natalia A. Chukhareva, Oksana V. Tsygankova, Galina A. Batisheva, Alena Paleskava, Olga G. Kompaniets, Galina G. Ketova, Valeriya O. Barysheva, Vera A. Nevzorova, Irina M. Martynenko, Sergey P. Pakhomov
Publikováno v:
Research Results in Pharmacology, Vol 8, Iss 4, Pp 57-64 (2022)
Introduction: The issues of rational antihypertensive therapy in pregnant women are always extremely relevant, since high blood pressure in a pregnant woman is associated with serious risks for a mother and a fetus. The aim of the study: To determine
Externí odkaz:
https://doaj.org/article/04a3af9396104a95b798f7235ebc3ce8
Autor:
Inna A. Volynkina, Elena N. Bychkova, Anastasiia O. Karakchieva, Alexander S. Tikhomirov, George V. Zatonsky, Svetlana E. Solovieva, Maksim M. Martynov, Natalia E. Grammatikova, Andrey G. Tereshchenkov, Alena Paleskava, Andrey L. Konevega, Petr V. Sergiev, Olga A. Dontsova, Ilya A. Osterman, Andrey E. Shchekotikhin, Anna N. Tevyashova
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 187 (2024)
The sustained rise of antimicrobial resistance (AMR) causes a strong need to develop new antibacterial agents. One of the methods for addressing the problem of antibiotic resistance is through the design of hybrid antibiotics. In this work, we propos
Externí odkaz:
https://doaj.org/article/807737912d584410b6286cfbdcf876e1
Autor:
Andrey G. Tereshchenkov, Zimfira Z. Khairullina, Inna A. Volynkina, Dmitrii A. Lukianov, Pavel A. Nazarov, Julia A. Pavlova, Vadim N. Tashlitsky, Elizaveta A. Razumova, Daria A. Ipatova, Yury V. Timchenko, Dmitry A. Senko, Olga V. Efremenkova, Alena Paleskava, Andrey L. Konevega, Ilya A. Osterman, Igor A. Rodin, Petr V. Sergiev, Olga A. Dontsova, Alexey A. Bogdanov, Natalia V. Sumbatyan
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 148 (2024)
Antimicrobial peptides (AMPs) have recently attracted attention as promising antibacterial agents capable of acting against resistant bacterial strains. In this work, an approach was applied, consisting of the conjugation of a peptide related to the
Externí odkaz:
https://doaj.org/article/070a9d24e6dc4c41b6503f6e3a7c5d29
Autor:
Julia A. Pavlova, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Vladimir I. Polshakov, Byasilya F. Vasilieva, Olga V. Efremenkova, Mikhail Y. Kaiumov, Alena Paleskava, Andrey L. Konevega, Olga A. Dontsova, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 15 (2022)
In order to obtain antimicrobial compounds with improved properties, new conjugates comprising two different biologically active agents within a single chimeric molecule based on chloramphenicol (CHL) and a hydrophobic cation were synthesized and stu
Externí odkaz:
https://doaj.org/article/a605ba928b33422cadcd2b7d2d8bc6a5
Autor:
Elena M. Maksimova, Daria S. Vinogradova, Ilya A. Osterman, Pavel S. Kasatsky, Oleg S. Nikonov, Pohl Milón, Olga A. Dontsova, Petr V. Sergiev, Alena Paleskava, Andrey L. Konevega
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusu
Externí odkaz:
https://doaj.org/article/aa4de2bb342943d5946698d32f450c37
Autor:
Alena Yakusheva, Olga Shulenina, Evgeny Pichkur, Alena Paleskava, Alexander Myasnikov, Andrey Konevega
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 24-25 (2021)
Background: The efficiency of widely used antibiotics is limited by continuous improvement of resistance mechanisms. Thus, the research of poorly studied drugs that have not received practical use until now becomes relevant again. Protein translation
Externí odkaz:
https://doaj.org/article/404d12a40c0742258bd0ee31b9004c11
Autor:
Daria S Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L Konevega, Pohl Milón
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000593 (2020)
During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and
Externí odkaz:
https://doaj.org/article/b125235495434d0f907a4142d204f90f
Autor:
Evgeny Pichkur, Pavel Kasatsky, Alena Paleskava, Alexander Myasnikov, Yury Polikanov, Ilya A. Osterman, Andrey Konevega
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S23-S23 (2019)
Background: Macrolide antibiotics bind in the nascent peptide exit tunnel (NPET) of the bacterial ribosome near the peptidyl transferase center. One of the second-generation macrolides, dirithromycin (DIR), differs from the parent erythromycin (ERY)
Externí odkaz:
https://doaj.org/article/b0e58deb649e414b902cde9807b69134
Autor:
Andrey Konevega, Evgeny Pichkur, Alena Paleskava, Pavel Kasatsky, Elena Maksimova, Daria Vinogradova, Yury Polikanov, Alexander Myasnikov
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S7-S7 (2019)
Background: About 50% of antibiotics used in the therapy of infectious diseases target bacterial 70S ribosomes. High resolution X-ray crystallographic studies allow us for determination of position of drug on the ribosome, but to elucidate the detail
Externí odkaz:
https://doaj.org/article/6576155958c04a7daa9a550d1b4e8450