Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alena Paleskava"'
Autor:
Inna A. Volynkina, Elena N. Bychkova, Anastasiia O. Karakchieva, Alexander S. Tikhomirov, George V. Zatonsky, Svetlana E. Solovieva, Maksim M. Martynov, Natalia E. Grammatikova, Andrey G. Tereshchenkov, Alena Paleskava, Andrey L. Konevega, Petr V. Sergiev, Olga A. Dontsova, Ilya A. Osterman, Andrey E. Shchekotikhin, Anna N. Tevyashova
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 187 (2024)
The sustained rise of antimicrobial resistance (AMR) causes a strong need to develop new antibacterial agents. One of the methods for addressing the problem of antibiotic resistance is through the design of hybrid antibiotics. In this work, we propos
Externí odkaz:
https://doaj.org/article/807737912d584410b6286cfbdcf876e1
Autor:
Andrey G. Tereshchenkov, Zimfira Z. Khairullina, Inna A. Volynkina, Dmitrii A. Lukianov, Pavel A. Nazarov, Julia A. Pavlova, Vadim N. Tashlitsky, Elizaveta A. Razumova, Daria A. Ipatova, Yury V. Timchenko, Dmitry A. Senko, Olga V. Efremenkova, Alena Paleskava, Andrey L. Konevega, Ilya A. Osterman, Igor A. Rodin, Petr V. Sergiev, Olga A. Dontsova, Alexey A. Bogdanov, Natalia V. Sumbatyan
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 148 (2024)
Antimicrobial peptides (AMPs) have recently attracted attention as promising antibacterial agents capable of acting against resistant bacterial strains. In this work, an approach was applied, consisting of the conjugation of a peptide related to the
Externí odkaz:
https://doaj.org/article/070a9d24e6dc4c41b6503f6e3a7c5d29
Autor:
Roman A. Bontsevich, Tatiana I. Balamutova, Natalia A. Chukhareva, Oksana V. Tsygankova, Galina A. Batisheva, Alena Paleskava, Olga G. Kompaniets, Galina G. Ketova, Valeriya O. Barysheva, Vera A. Nevzorova, Irina M. Martynenko, Sergey P. Pakhomov
Publikováno v:
Research Results in Pharmacology, Vol 8, Iss 4, Pp 57-64 (2022)
Introduction: The issues of rational antihypertensive therapy in pregnant women are always extremely relevant, since high blood pressure in a pregnant woman is associated with serious risks for a mother and a fetus. The aim of the study: To determine
Externí odkaz:
https://doaj.org/article/04a3af9396104a95b798f7235ebc3ce8
Autor:
Julia A. Pavlova, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Vladimir I. Polshakov, Byasilya F. Vasilieva, Olga V. Efremenkova, Mikhail Y. Kaiumov, Alena Paleskava, Andrey L. Konevega, Olga A. Dontsova, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 15 (2022)
In order to obtain antimicrobial compounds with improved properties, new conjugates comprising two different biologically active agents within a single chimeric molecule based on chloramphenicol (CHL) and a hydrophobic cation were synthesized and stu
Externí odkaz:
https://doaj.org/article/a605ba928b33422cadcd2b7d2d8bc6a5
Autor:
Elena M. Maksimova, Daria S. Vinogradova, Ilya A. Osterman, Pavel S. Kasatsky, Oleg S. Nikonov, Pohl Milón, Olga A. Dontsova, Petr V. Sergiev, Alena Paleskava, Andrey L. Konevega
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusu
Externí odkaz:
https://doaj.org/article/aa4de2bb342943d5946698d32f450c37
Autor:
Alena Yakusheva, Olga Shulenina, Evgeny Pichkur, Alena Paleskava, Alexander Myasnikov, Andrey Konevega
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 24-25 (2021)
Background: The efficiency of widely used antibiotics is limited by continuous improvement of resistance mechanisms. Thus, the research of poorly studied drugs that have not received practical use until now becomes relevant again. Protein translation
Externí odkaz:
https://doaj.org/article/404d12a40c0742258bd0ee31b9004c11
Autor:
Daria S Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L Konevega, Pohl Milón
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000593 (2020)
During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and
Externí odkaz:
https://doaj.org/article/b125235495434d0f907a4142d204f90f
Autor:
Alena Paleskava, Elena M. Maksimova, Daria S. Vinogradova, Pavel S. Kasatsky, Stanislav V. Kirillov, Andrey L. Konevega
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9614 (2021)
The growth of the polypeptide chain occurs due to the fast and coordinated work of the ribosome and protein elongation factors, EF-Tu and EF-G. However, the exact contribution of each of these components in the overall balance of translation kinetics
Externí odkaz:
https://doaj.org/article/e952b5fe08a14abbaf1cd04555f44914
Autor:
Chih-Wei Chen, Julia A. Pavlova, Dmitrii A. Lukianov, Andrey G. Tereshchenkov, Gennady I. Makarov, Zimfira Z. Khairullina, Vadim N. Tashlitsky, Alena Paleskava, Andrey L. Konevega, Alexey A. Bogdanov, Ilya A. Osterman, Natalia V. Sumbatyan, Yury S. Polikanov
Publikováno v:
Antibiotics, Vol 10, Iss 4, p 390 (2021)
Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving the properties of this
Externí odkaz:
https://doaj.org/article/3bcc4395e05d4903a35a3ea5653542a7
Autor:
Julia A. Pavlova, Zimfira Z. Khairullina, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Inna A. Volynkina, Dmitry A. Skvortsov, Gennady I. Makarov, Etna Abad, Somay Y. Murayama, Susumu Kajiwara, Alena Paleskava, Andrey L. Konevega, Yuri N. Antonenko, Alex Lyakhovich, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Publikováno v:
Antibiotics, Vol 10, Iss 5, p 489 (2021)
In the current work, in continuation of our recent research, we synthesized and studied new chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) and the membrane-penetrating cation triphenylphosphonium (TPP), which ar
Externí odkaz:
https://doaj.org/article/d7e64d55801f418cb67a84cf4c2c37fb