Novel frontiers in urogenital cancers: from molecular bases to preclinical models to tailor personalized treatments in ovarian and prostate cancer patients

Autor: Giada De Lazzari, Alena Opattova, Sabrina Arena

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-26 (2024)

Abstract Over the last few decades, the incidence of urogenital cancers has exhibited diverse trends influenced by screening programs and geographical variations. Among women, there has been a consistent or even increased occurrence of endometrial an

Externí odkaz: https://doaj.org/article/4fc2c0ba129a455681f9bddd8733bc9b

Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients

Autor: Klara Cervena, Vendula Novosadova, Barbara Pardini, Alessio Naccarati, Alena Opattova, Josef Horak, Sona Vodenkova, Tomas Buchler, Pavel Skrobanek, Miroslav Levy, Pavel Vodicka, Veronika Vymetalkova

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

MicroRNAs (miRNAs) regulate gene expression in a tissue-specific manner. However, little is known about the miRNA expression changes induced by the therapy in rectal cancer (RC) patients. We evaluated miRNA expression levels before and after therapy

Externí odkaz: https://doaj.org/article/0fce0d73d1a041b9ac949c865103fdbc

A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors

Autor: Alena Opattova, Sabine A.S. Langie, Mirta Milic, Andrew Collins, Asgeir Brevik, Erdem Coskun, Maria Dusinska, Isabel Gaivão, Ela Kadioglu, Blanca Laffon, Ricard Marcos, Susana Pastor, Jana Slyskova, Bozena Smolkova, Zsófia Szilágyi, Vanessa Valdiglesias, Pavel Vodicka, Katarina Volkovova, Stefano Bonassi, Roger W.L. Godschalk

Publikováno v: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 876-877:503447. Elsevier

Levels of DNA damage represent the dynamics between damage formation and removal. Therefore, to better interpret human biomonitoring studies with DNA damage endpoints, an individual's ability to recognize and properly remove DNA damage should be char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51e1c3ce6bab3d19e4732828a7141a6
https://pubmed.ncbi.nlm.nih.gov/35483778

An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity

Autor: Isabel Gaivão, Alena Opattova, Amaya Azqueta, Roger W. L. Godschalk, Peter Møller, Pavel Vodicka, Sabine A. S. Langie, Sona Vodenkova, Maria Dusinska, Andrew Collins

Publikováno v: Nature Protocols, 15(12), 3844-3878. Nature Publishing Group
Vodenkova, S, Azqueta, A, Collins, A, Dusinska, M, Gaivao, I, Møller, P, Opattova, A, Vodicka, P, Godschalk, R W L & Langie, S A S 2020, ' An optimized comet-based in vitro DNA repair assay to assess base and nucleotide excision repair activity ', Nature Protocols, vol. 15, pp. 3844–3878 . https://doi.org/10.1038/s41596-020-0401-x
Nature Protocols

This optimized protocol (including links to instruction videos) describes a comet-based in vitro DNA repair assay that is relatively simple, versatile, and inexpensive, enabling the detection of base and nucleotide excision repair activity. Protein e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e3676d540baba829f4f94c0f17895
https://cris.maastrichtuniversity.nl/en/publications/e033f6dc-1d6a-490e-ab22-99c28a0fc192

Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer

Autor: Vlasta Korenkova, Vaclav Liska, Julius Spicak, Katerina Jiraskova, Vendula Novosadova, Miroslav Levy, Pavel Vodicka, Veronika Veskrnova, Jan Kral, Alena Opattova, Lucie Langerova, Michaela Schneiderova, Jana Slyskova, Veronika Vymetalkova

Publikováno v: Carcinogenesis. 39:1359-1367

MicroRNA (miRNA) profiling represents a promising source of cancer-related biomarkers. miRNA signatures are specific for each cancer type and subgroups of patients with diverse treatment sensitivity. Yet this miRNA potential has not been satisfactori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56448ec03b889742e54c64a69cc3f7a
https://doi.org/10.1093/carcin/bgy100