Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alena Kozlova"'
Autor:
Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-27 (2022)
Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dyna
Externí odkaz:
https://doaj.org/article/5b885f3d291245d3b19ec792e0b820ed
Autor:
Boqiao Lai, Sheng Qian, Hanwei Zhang, Siwei Zhang, Alena Kozlova, Jubao Duan, Jinbo Xu, Xin He
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 5, p e1010011 (2022)
Genomewide association studies (GWAS) have identified a large number of loci associated with neuropsychiatric traits, however, understanding the molecular mechanisms underlying these loci remains difficult. To help prioritize causal variants and inte
Externí odkaz:
https://doaj.org/article/6b44a54df1cc4e96b399c22c2124839f
Autor:
Stefano Espinoza, Ilya Sukhanov, Evgeniya V. Efimova, Alena Kozlova, Kristina A. Antonova, Placido Illiano, Damiana Leo, Natalia Merkulyeva, Daria Kalinina, Pavel Musienko, Anna Rocchi, Liudmila Mus, Tatiana D. Sotnikova, Raul R. Gainetdinov
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Trace amine-associated receptors (TAARs) are a class of G-protein-coupled receptors found in mammals. While TAAR1 is expressed in several brain regions, all the other TAARs have been described mainly in the olfactory epithelium and the glomerular lay
Externí odkaz:
https://doaj.org/article/4a6b41f442ce4632b33685dd4a83d9a5
Autor:
Alena Kozlova, Siwei Zhang, Alex V. Kotlar, Brendan Jamison, Hanwen Zhang, Serena Shi, Marc P. Forrest, John McDaid, David J. Cutler, Michael P. Epstein, Michael E. Zwick, Zhiping P. Pang, Alan R. Sanders, Stephen T. Warren, Pablo V. Gejman, Jennifer G. Mulle, Jubao Duan
Publikováno v:
Am J Hum Genet
Identifying causative gene(s) within disease-associated large genomic regions of copy-number variants (CNVs) is challenging. Here, by targeted sequencing of genes within schizophrenia (SZ)-associated CNVs in 1,779 SZ cases and 1,418 controls, we iden
Autor:
Paul Vezina, Hanwen Zhang, Robert R. Butler, Alena Kozlova, Stephan Steidl, Jubao Duan, Zhiping P. Pang, Alan R. Sanders, Siwei Zhang, Thomas Ujas
Publikováno v:
Neuropsychopharmacology
Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA and their biological relevance to the mounting genome-wide association study (GWAS) loci of
Autor:
Siwei Zhang, Hanwen Zhang, Marc P. Forrest, Yifan Zhou, Vikram A. Bagchi, Alena Kozlova, Marc Dos Santos, Nicolas H. Piguel, Leonardo E. Dionisio, Alan R. Sanders, Zhiping P. Pang, Xin He, Peter Penzes, Jubao Duan
Despite hundreds of risk loci from genome-wide association studies of neuropsychiatric disorders, causal variants/genes remain largely unknown. Here, in NEUROG2-induced human neurons, we identified 31 risk SNPs in 26 schizophrenia (SZ) risk loci that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78438acfd89723a37954f48b8119acde
https://doi.org/10.1101/2021.12.11.472229
https://doi.org/10.1101/2021.12.11.472229
Autor:
A.N. Vaganova, Savelii R. Kuvarzin, Daria Kalinina, Maria A. Ptukha, T S Shemiakova, Ramilya Z. Murtazina, Raul R. Gainetdinov, Anna B. Volnova, Pavel Musienko, Natalia Merkulyeva, Alena Kozlova, A V Goriainova
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that
Autor:
Siwei Zhang, Hanwen Zhang, Lifang Liang, Lexi Li, Brendan Jamison, Whitney Wood, Alena Kozlova, Alan Sanders, Zhiping Pang, Xin He, Jubao Duan
Publikováno v:
European Neuropsychopharmacology. 63:e34
Autor:
I. V. Karpova, S. G. Dagayev, Raul R. Gainetdinov, Alena Kozlova, E. L. Sinitca, I. Y. Tissen, V. A. Kashuro, Ilya S. Zhukov, L. G. Kubarskaya, O. L. Vlasova
Publikováno v:
Cellular and Molecular Neurobiology. 40:273-282
Since the discovery in 2001, the G protein-coupled trace amine-associated receptor 1 (TAAR1) has become an important focus of research targeted on evaluation of its role in the central nervous system (CNS). Meanwhile, impact of TAAR1 in the periphera
Autor:
Jasmin Morandell, Ximena Contreras, Elena Deliu, Kasumi Kishi, Gaia Novarino, Eva-Lotta Käsper, Ilaria Chiaradia, Charles Girardot, Alena Kozlova, Niccolò Arecco, Christoph P. Dotter, Kyung-Min Noh
Publikováno v:
Nature Neuroscience. 21:1717-1727
SETD5 gene mutations have been identified as a frequent cause of idiopathic intellectual disability. Here we show that Setd5-haploinsufficient mice present developmental defects such as abnormal brain-to-body weight ratios and neural crest defect-ass