Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alena Klochkova"'
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Autor:
Annie D. Fuller, Adam L. Karami, Mohammad Faujul Kabir, Alena Klochkova, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Andres J. Klein-Szanto, Kelly A. Whelan
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
IntroductionUnder homeostatic conditions, esophageal epithelium displays a proliferation/differentiation gradient that is generated as proliferative basal cells give rise to suprabasal cells then terminally differentiated superficial cells. This prol
Externí odkaz:
https://doaj.org/article/bfa60c20b4244bd9b9ed3cd95ddddc6d
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The level of cellular diversity in the esophageal epithelium has yet to be classified at the single cell level. Here the authors analyze the transcriptome of 44,679 murine esophageal keratinocytes to identify an unexpected level of cellular heterogen
Externí odkaz:
https://doaj.org/article/08d60dfa06354f1792c694cb232b3b9d
Autor:
Alena Klochkova, Annie D. Fuller, Riley Miller, Adam L. Karami, Surali R. Panchani, Shruthi Natarajan, Anbin Mu, Jazmyne L. Jackson, Andres J. Klein-Szanto, Amanda B. Muir, Kelly A. Whelan
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Subepithelial fibrosis occurs in a subset of eosinophilic esophagitis (EoE) patients and is associated with esophageal stricture. While mechanisms driving EoE fibrosis remain incompletely understood, findings from experimental systems support roles f
Externí odkaz:
https://doaj.org/article/70fd8a55c4ad44cc9bb32754ad67cee8
Autor:
Reshu Saxena, Alena Klochkova, Mary Grace Murray, Mohammad Faujul Kabir, Safiyah Samad, Tyler Beccari, Julie Gang, Kishan Patel, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cancers, Vol 11, Iss 11, p 1697 (2019)
Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of
Externí odkaz:
https://doaj.org/article/c5135756dbd14edfac8c4c10d50af5f7
Autor:
Mohammad Faujul Kabir, Jazmyne L Jackson, Annie D Fuller, Leonny Gathuka, Adam L Karami, Don-Gerard Conde, Alena Klochkova, Anbin Mu, Kathy Q Cai, Andres J Klein-Szanto, Amanda B Muir, Kelly A Whelan
Publikováno v:
Carcinogenesis. 44:182-195
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of human malignancy, often displaying limited therapeutic response. Here, we examine the non-steroidal anti-inflammatory drug diclofenac (DCF) as a novel therapeutic agent
Autor:
Nicolette M Johnson, Louis R Parham, Jeeyoon Na, Keara E Monaghan, Hannah M Kolev, Alena Klochkova, Melissa S Kim, Charles H Danan, Zvi Cramer, Lauren A Simon, Kaitlyn E Naughton, Stephanie Adams‐Tzivelekidis, Yuhua Tian, Patrick A Williams, N Adrian Leu, Simone Sidoli, Kelly A Whelan, Ning Li, Christopher J Lengner, Kathryn E Hamilton
Publikováno v:
EMBO reports. 23(11)
The intestinal epithelium exhibits a rapid and efficient regenerative response to injury. Emerging evidence supports a model where plasticity of differentiated cells, particularly those in the secretory lineages, contributes to epithelial regeneratio
Autor:
Louis R. Parham, Nicolette Johnson, Jeeyoon Na, Alena Klochkova, Patrick Williams, Ning Li, Kelly A. Whelan, Christopher J. Lengner, Kathryn E. Hamilton
Publikováno v:
The FASEB Journal. 36
Autor:
Alena Klochkova, Adam Kamari, Louis Parham, Mary Grace Murray, Kathryn Hamilton, Kelly Whelan
Publikováno v:
The FASEB Journal. 36
Autor:
Anne Fuller, Mohammad F. Kabir, Adam Karami, Alena Klochkova, Anbin Mu, Andres Klein‐Szanto, Kathryn Hamilton, Kelly Whelan
Publikováno v:
The FASEB Journal. 36