Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters.

Autor: Min Hi Park, Jeffrey L Suhalim, Firas Elmastour, Santu K Singha, Tadashi Imafuku, Ramanathan Venkatnarayan, Anette Christ, Alena Grebe, Sarah A Oppelt, Dmitri Sviridov, Michael Bukrinsky, Eicke Latz, Eric O Potma, Michael L Fitzgerald

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251599 (2021)

Chronic HIV infection may exacerbate atherosclerotic vascular disease, which at advanced stages presents as necrotic plaques rich in crystalline cholesterol. Such lesions can catastrophically rupture precipitating myocardial infarct and stroke, now i

Externí odkaz: https://doaj.org/article/7d927e6dabde409bb967982a5d3e7a01

Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters

Autor: Anette Christ, Michael L. Fitzgerald, Sarah A. Oppelt, Firas Elmastour, Eicke Latz, Tadashi Imafuku, Min Hi Park, Santu K. Singha, Jeffrey L. Suhalim, Dmitri Sviridov, Alena Grebe, Eric O. Potma, Ramanathan Venkatnarayan, Michael Bukrinsky

Publikováno v: PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251599 (2021)
PLoS ONE

Chronic HIV infection may exacerbate atherosclerotic vascular disease, which at advanced stages presents as necrotic plaques rich in crystalline cholesterol. Such lesions can catastrophically rupture precipitating myocardial infarct and stroke, now i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e625f0dbb2894b02d28f3d64d5e34c43
https://escholarship.org/uc/item/0wc0g1v7

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Autor: Florian Hoss, Eicke Latz, Alena Grebe

Publikováno v: Circulation research 122(12), 1722-1740 (2018). doi:10.1161/CIRCRESAHA.118.311362

Inflammation is an important driver of atherosclerosis, the underlying pathology of cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is suggested to improve cardiovascular outcomes in patients with cardiovascular dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b7ab1f22619d6fa2fbb49758ad4db1
https://pubmed.ncbi.nlm.nih.gov/29880500

Danger Signaling in Atherosclerosis

Autor: Sebastian Zimmer, Alena Grebe, Eicke Latz

Publikováno v: Circulation research 116(2), 323-340 (2015). doi:10.1161/CIRCRESAHA.116.301135

All aspects of the pathogenesis of atherosclerosis are critically influenced by the inflammatory response in vascular plaques. Research in the field of innate immunity from the past 2 decades has uncovered many novel mechanisms elucidating how immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25daa1b5e9fe9e6236982f13fcd127a
https://doi.org/10.1161/circresaha.116.301135

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Autor: Samuel D. Wright, Niklas Bode, Alena Grebe, Thomas Ulas, Anja Kerksiek, Jan-Åke Gustafsson, Terje Espevik, Victoria Hawxhurst, Ingemar Björkhem, Chris Hempel, Larisa I. Labzin, Marit Westerterp, Siril Skaret Bakke, Joachim L. Schultze, Jonel Trebicka, Sebastian Zimmer, Georg Nickenig, Mona Skjelland, Dominic De Nardo, Bente Halvorsen, Michael T. Heneka, Dieter Lütjohann, Eicke Latz, Alan R. Tall, Michael L. Fitzgerald

Publikováno v: Zimmer, S, Grebe, A, Bakke, S S, Bode, N, Halvorsen, B, Ulas, T, Skjelland, M, De Nardo, D, Labzin, L I, Kerksiek, A, Hempel, C, Heneka, M T, Hawxhurst, V, Fitzgerald, M L, Trebicka, J, Björkhem, I, Gustafsson, J-Å, Westerterp, M, Tall, A R, Wright, S D, Espevik, T, Schultze, J L, Nickenig, G, Lütjohann, D & Latz, E 2016, ' Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming ', Science Translational Medicine, vol. 8, no. 333, pp. 333ra50 . https://doi.org/10.1126/scitranslmed.aad6100
Science translational medicine 8(333), 333ra50-333ra50 (2016). doi:10.1126/scitranslmed.aad6100
Science Translational Medicine, 8(333):333ra50. AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine

Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol concentrations. Despite ongoing advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains the leading cause of death worldwide. Continuo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccf8108c41d12704fc35cda975f51c3
https://pubmed.ncbi.nlm.nih.gov/27121648