Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Alem W, Kahsai"'
Autor:
Badr Sokrat, Anthony H. Nguyen, Alex R. B. Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W. Kahsai, Jihee Kim, Bing X. Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, Michel Bouvier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Classically, G protein-coupled receptors (GPCRs) promote signaling at the plasma membrane through activation of heterotrimeric Gαβγ proteins, followed by the recruitment of GPCR kinases and βarrestin (βarr) to initiate receptor desensit
Externí odkaz:
https://doaj.org/article/5849f72408344b829ffc02844067159b
Autor:
Seungkirl Ahn, Harm Maarsingh, Julia K.L. Walker, Samuel Liu, Akhil Hegde, Hyeje C. Sumajit, Alem W. Kahsai, Robert J. Lefkowitz
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Asthma is a chronic inflammatory disease associated with episodic airway narrowing. Inhaled β2-adrenergic receptor (β2AR) agonists (β2-agonists) promote — with limited efficacy — bronchodilation in asthma. All β2-agonists are canonical orthos
Externí odkaz:
https://doaj.org/article/7baee4fa0bf4499f85b0ab428028efe2
Autor:
Qi Liu, Qing-tao He, Xiaoxuan Lyu, Fan Yang, Zhong-liang Zhu, Peng Xiao, Zhao Yang, Feng Zhang, Zhao-ya Yang, Xiao-yan Wang, Peng Sun, Qian-wen Wang, Chang-xiu Qu, Zheng Gong, Jing-yu Lin, Zhen Xu, Shao-le Song, Shen-ming Huang, Sheng-chao Guo, Ming-jie Han, Kong-kai Zhu, Xin Chen, Alem W. Kahsai, Kun-Hong Xiao, Wei Kong, Fa-hui Li, Ke Ruan, Zi-jian Li, Xiao Yu, Xiao-gang Niu, Chang-wen Jin, Jiangyun Wang, Jin-peng Sun
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Characterization of dynamic conformational changes in membrane protein complexes by NMR spectroscopy remains challenging. Here authors report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMSiPhe) into proteins, which enabled the
Externí odkaz:
https://doaj.org/article/9e525d39c3704658bb31c1f7b6676d76
Autor:
Chun-Hua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-Jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei-Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-Fang He, Chang-xiu Qu, Peng Xiao, Chuan-Yong Liu, Alex R. B. Thomsen, Thomas Joseph Cahill, Alem W. Kahsai, Fan Yi, Kun-Hong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, Jin-Peng Sun
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-indepe
Externí odkaz:
https://doaj.org/article/fd8251bd4bfc4bada3441c9bdef9e02e
Autor:
Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, Yuan Gao, Zhao Yang, Dong-Fang He, Amy Lin, Hui Mo, Yu-Jing Lu, Meng-Jing Li, Wei Kong, Ka Young Chung, Fan Yi, Jian-Yuan Li, Ying-Ying Qin, Jingxin Li, Alex R B Thomsen, Alem W Kahsai, Zi-Jiang Chen, Zhi-Gang Xu, Mingyao Liu, Dali Li, Xiao Yu, Jin-Peng Sun
Publikováno v:
eLife, Vol 7 (2018)
Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGR
Externí odkaz:
https://doaj.org/article/160cb752179d4fe99a359e4cf629a263
Autor:
Paula K. Rambarat, Biswaranjan Pani, Robert J. Lefkowitz, Shashank Vege, Seungkirl Ahn, Dean P. Staus, Bruno N. Valan, Tommaso Costa, Alem W. Kahsai, Andrew Liu
Publikováno v:
Molecular Pharmacology. 100:513-525
Among β-blockers that are clinically prescribed for heart failure, carvedilol is a first-choice agent with unique pharmacological properties. Carvedilol is distinct from other β-blockers in its ability to elicit β-arrestin-biased agonism, which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7ae1a5d7fc7bdd6a4374179ff46d40
https://doi.org/10.1124/molpharm.121.000363
https://doi.org/10.1124/molpharm.121.000363
Autor:
Seungkirl Ahn, Howard A. Rockman, Haoran Jiang, Ilhan Gokhan, Jialu Wang, Xinyu Xiong, Biswaranjan Pani, Robert J. Lefkowitz, Alem W. Kahsai
Publikováno v:
Mol Pharmacol
β(1) adrenergic receptors (β(1)ARs) are central regulators of cardiac function and a drug target for cardiac disease. As a member of the G protein–coupled receptor family, β(1)ARs activate cellular signaling by primarily coupling to Gs proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899cdde539ac9323e772614fd83c35b4
https://doi.org/10.1124/molpharm.121.000359
https://doi.org/10.1124/molpharm.121.000359
Autor:
Jing-Yu Lin, Changxiu Qu, Qi Liu, Changwen Jin, Peng Sun, Sheng-chao Guo, Xiaoyan Wang, Xiaogang Niu, Zhao Yang, Zhen Xu, Zijian Li, Peng Xiao, Kunhong Xiao, Zhongliang Zhu, Fahui Li, Qing-tao He, Xin Chen, Zheng Gong, Ke Ruan, Jiangyun Wang, Shao-le Song, Jin-Peng Sun, Kong-kai Zhu, Feng Zhang, Qian-wen Wang, Fan Yang, Zhao-ya Yang, Wei Kong, Xiao Yu, Xiao-xuan Lyu, Ming-Jie Han, Shen-Ming Huang, Alem W. Kahsai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d701f67806ee58b619fe7d0ee8cdf42
http://link.springer.com/article/10.1038/s41467-020-18433-5
http://link.springer.com/article/10.1038/s41467-020-18433-5
Publikováno v:
The Journal of Biological Chemistry
G protein-coupled receptors (GPCRs) convert external stimuli into cellular signals through heterotrimeric guanine nucleotide-binding proteins (G-proteins) and β-arrestins (βarrs). In a βarr-dependent signaling pathway, βarrs link GPCRs to various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaf4416497c7699797de531ddaae175
https://pubmed.ncbi.nlm.nih.gov/34757127
https://pubmed.ncbi.nlm.nih.gov/34757127
Autor:
Biswaranjan, Pani, Seungkirl, Ahn, Paula K, Rambarat, Shashank, Vege, Alem W, Kahsai, Andrew, Liu, Bruno N, Valan, Dean P, Staus, Tommaso, Costa, Robert J, Lefkowitz
Publikováno v:
Molecular pharmacology. 100(5)
Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a25ba5f5598267b2a18bff03e4dc43d9
https://pubmed.ncbi.nlm.nih.gov/34862306
https://pubmed.ncbi.nlm.nih.gov/34862306