Broadly potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages

Autor: Melanie R. Walker, Alexander Underwood, Kasper H. Björnsson, Sai Sundar Rajan Raghavan, Maria R. Bassi, Alekxander Binderup, Long V. Pham, Santseharay Ramirez, Mette Pinholt, Robert Dagil, Anne S. Knudsen, Manja Idorn, Max Soegaard, Kaituo Wang, Andrew B. Ward, Ali Salanti, Jens Bukh, Lea Barfod

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Abstract The continuous emergence of SARS-CoV-2 variants of concern has rendered many therapeutic monoclonal antibodies (mAbs) ineffective. To date, there are no clinically authorized therapeutic antibodies effective against the recently circulating

Externí odkaz: https://doaj.org/article/2b11d3e3d9f0431f9a67e240f7b90062

Neutralizing antibody and CD8+ T cell responses following BA.4/5 bivalent COVID-19 booster vaccination in adults with and without prior exposure to SARS-CoV-2

Autor: Alexander P. Underwood, Christina Sølund, Kivin Jacobsen, Alekxander Binderup, Carlota Fernandez-Antunez, Lotte S. Mikkelsen, Dilek Inekci, Signe Lysemose Villadsen, Jose A. S. Castruita, Mette Pinholt, Ulrik Fahnøe, Santseharay Ramirez, Liselotte Brix, Nina Weis, Jens Bukh

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

As severe acute respiratory coronavirus 2 (SARS-CoV-2) variants continue to emerge, it is important to characterize immune responses against variants which can inform on protection efficacies following booster vaccination. In this study, neutralizing

Externí odkaz: https://doaj.org/article/f4f02d14888b456b8a2729d7250fc4fc

Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir

Autor: Karen Anbro Gammeltoft, Yuyong Zhou, Line Abildgaard Ryberg, Long V. Pham, Alekxander Binderup, Carlos Rene Duarte Hernandez, Anna Offersgaard, Ulrik Fahnøe, Günther Herbert Johannes Peters, Santseharay Ramirez, Jens Bukh, Judith Margarete Gottwein

Publikováno v: Viruses, Vol 15, Iss 9, p 1970 (2023)

Nirmatrelvir, which targets the SARS-CoV-2 main protease (Mpro), is the first-in-line drug for prevention and treatment of severe COVID-19, and additional Mpro inhibitors are in development. However, the risk of resistance development threatens the f

Externí odkaz: https://doaj.org/article/68742ea5f82c460db78afaf14d9d85da

Durability and breadth of neutralisation following multiple antigen exposures to SARS-CoV-2 infection and/or COVID-19 vaccination

Autor: Alexander P. Underwood, Christina Sølund, Carlota Fernandez-Antunez, Signe Lysemose Villadsen, Lotte S. Mikkelsen, Ulrik Fahnøe, Signe Bollerup, Anni Assing Winckelmann, Uffe Vest Schneider, Alekxander Binderup, Greta Vizgirda, Anna-Louise Sørensen, Caroline Nørløv Vinten, Magnus Illum Dalegaard, Santseharay Ramirez, Nina Weis, Jens Bukh

Publikováno v: Underwood, A P, Sølund, C, Fernandez-Antunez, C, Villadsen, S L, Mikkelsen, L S, Fahnøe, U, Bollerup, S, Winckelmann, A A, Schneider, U V, Binderup, A, Vizgirda, G, Sørensen, A L, Vinten, C N, Dalegaard, M I, Ramirez, S, Weis, N & Bukh, J 2023, ' Durability and breadth of neutralisation following multiple antigen exposures to SARS-CoV-2 infection and/or COVID-19 vaccination ', EBioMedicine, vol. 89, 104475 . https://doi.org/10.1016/j.ebiom.2023.104475

Background: Given the importance of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the prevention of severe coronavirus disease 2019 (COVID-19), detailed long-term analyses of neutralising antibody responses are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada4738d369e1e0a8bbd9c5c7165003a
https://curis.ku.dk/portal/da/publications/durability-and-breadth-of-neutralisation-following-multiple-antigen-exposures-to-sarscov2-infection-andor-covid19-vaccination(3d027e81-676c-49f8-97bf-48b42646380b).html

Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system

Autor: Yuyong Zhou, Karen Anbro Gammeltoft, Line Abildgaard Ryberg, Long V. Pham, Helena Damtoft Tjørnelund, Alekxander Binderup, Carlos Rene Duarte Hernandez, Carlota Fernandez-Antunez, Anna Offersgaard, Ulrik Fahnøe, Günther Herbert Johannes Peters, Santseharay Ramirez, Jens Bukh, Judith Margarete Gottwein

Publikováno v: Zhou, Y, Gammeltoft, K A, Ryberg, L A, Pham, L V, Tjørnelund, H D, Binderup, A, Hernandez, C R D, Fernandez-Antunez, C, Offersgaard, A, Fahnøe, U, Peters, G H J, Ramirez, S, Bukh, J & Gottwein, J M 2022, ' Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system ', Science Advances, vol. 8, no. 51, eadd7197 . https://doi.org/10.1126/sciadv.add7197

The oral protease inhibitor nirmatrelvir is of key importance for prevention of severe coronavirus disease 2019 (COVID-19). To facilitate resistance monitoring, we studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from nirma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d727551774267d20853f0010a21cfc8
https://orbit.dtu.dk/en/publications/3f6c81f6-93ab-4100-b45b-e62a8282a572