Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Aleksia Barka"'
Autor:
Juan C. Serrano, Dora von Trentini, Kiara N. Berríos, Aleksia Barka, Ivan J. Dmochowski, Rahul M. Kohli
Publikováno v:
ACS Chemical Biology. 17:3379-3388
Nucleic acid structure plays a critical role in governing the selectivity of DNA- and RNA-modifying enzymes. In the case of the APOBEC3 family of cytidine deaminases, these enzymes catalyze the conversion of cytosine (C) to uracil (U) in single-stran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6923fb73a9b6842a580a31b0eea4a7
https://doi.org/10.1021/acschembio.2c00796
https://doi.org/10.1021/acschembio.2c00796
Publikováno v:
ACS Chem Biol
Human APOBEC3A (A3A) is a nucleic acid-modifying enzyme that belongs to the cytidine deaminase family. Canonically, A3A catalyzes the deamination of cytosine into uracil in single-stranded DNA, an activity that makes A3A both a critical antiviral def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3691d6826403f54ee5705303553383cd
https://doi.org/10.1021/acschembio.1c00919
https://doi.org/10.1021/acschembio.1c00919
Autor:
Kiara N. Berríos, Aleksia Barka, Jasleen Gill, Niklaus H. Evitt, Kiran S. Gajula, Junwei Shi, Rahul M. Kohli
The partnership of DNA deaminase enzymes with CRISPR-Cas nucleases is now a well-established method to enable targeted genomic base editing. However, an understanding of how Cas9 and DNA deaminases collaborate to shape base editor (BE) outcomes has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b83176e2ed3ec28d3bd763259c36cad
https://doi.org/10.1101/2022.12.03.518995
https://doi.org/10.1101/2022.12.03.518995
Autor:
Meiqi Luo, Caroline Bartman, Rahul M. Kohli, Niklaus H. Evitt, Junwei Shi, Rachel A. DeWeerd, Yemin Lan, Kiara N. Berríos, Aleksia Barka, Tong Wang, Diqiu Ren, Abby M. Green
Publikováno v:
Nat Chem Biol
DNA deaminase enzymes play key roles in immunity and have recently been harnessed for their biotechnological applications. In base editors (BEs), the combination of DNA deaminase mutator activity with CRISPR-Cas localization confers the powerful abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4718df94f1d5e88c35d7b1aa0651f982
https://doi.org/10.1038/s41589-021-00880-w
https://doi.org/10.1038/s41589-021-00880-w