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of 7
pro vyhledávání: '"Aleksey V. Shchulkin"'
Autor:
Aleksey V. Shchulkin, Yulia V. Abalenikhina, Aleksandr A. Slepnev, Egor D. Rokunov, Elena N. Yakusheva
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9593-9605 (2023)
Organic anion transporting polypeptide 1B1 (OATP1B1) is an influx transporter protein of the SLC superfamily, expressed mainly in the liver and some tumor cells. The mechanisms of its regulation are being actively studied. In the present study, the e
Externí odkaz:
https://doaj.org/article/ce89e97d2119492f961b846c0c9c851d
Autor:
Aleksey V. Shchulkin, Yulia V. Abalenikhina, Olga V. Kosmachevskaya, Alexey F. Topunov, Elena N. Yakusheva
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 215 (2024)
P-glycoprotein (Pgp, ABCB1, MDR1) is an efflux transporter protein that removes molecules from the cells (outflow) into the extracellular space. Pgp plays an important role in pharmacokinetics, ensuring the absorption, distribution, and excretion of
Externí odkaz:
https://doaj.org/article/d2528d280b5d4b8f950170409e1a505b
Autor:
Aleksey V. Shchulkin, Pelageya D. Erokhina, Anna V. Goncharenko, Pavel Yu. Mylnikov, Ivan V. Chernykh, Yulia V. Abalenikhina, Maria S. Kotliarova, Elena N. Yakusheva
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1529 (2023)
2-Ethyl-6-methyl-3-hydroxypyridine succinate (EMHPS, Mexidol) is an original antioxidant and an anti-ischemic drug with the possibility of wide applications in the complex therapy of diseases, accompanied by the development of oxidative stress and is
Externí odkaz:
https://doaj.org/article/27e3a63a4f6246beacacfaa4b9efeea0
Autor:
Ivan V. Chernykh, Aleksey V. Shchulkin, Sergei K. Pravkin, Maria V. Gatsanoga, Elena N. Yakusheva
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 15, Iss 1, Pp 65-70 (2021)
Introduction. Despite the development of numerous drugs with neuroprotective activity, their efficacy in cerebrovascular disease remains low, which may partly be due to the efflux function of protein ABCB1 and insufficient penetration of the blood-br
Externí odkaz:
https://doaj.org/article/ab63bab3719e4a42ba93af3d72c684bf
Autor:
Yulia V. Abalenikhina, Aleksey V. Shchulkin, Pavel Yu. Mylnikov, Egor D. Rokunov, Elena N. Yakusheva
Publikováno v:
Acta Naturae. 14:69-78
We investigated the mechanisms of P-glycoprotein (P-gp) transporter regulation in Caco-2 cells under exogenous and endogenous oxidative stress (OS). Exogenous OS was modeled by exposure of the growth medium to hydrogen peroxide at concentrations of 0
Autor:
Aleksey V. Shchulkin, Yulia V. Abalenikhina, Elena A. Sudakova, Pavel Yu. Mylnikov, Elena N. Yakusheva
Publikováno v:
Biochemistry (Moscow). 87:366-379
Mechanisms of regulation of the P-glycoprotein (Pgp) transporter under the action of nitric oxide (NO) were studied in Caco-2 cells. S-Nitrosoglutathione (GSNO) was used as a NO donor, which was added to the cells at concentrations 1, 10, 50, 100, an
Autor:
Ivan V. Chernykh, Ekarina E. Kirichenko, Aleksey V. Shchulkin, Natalia M. Popova, Anna A. Kotlyarova
Publikováno v:
I.P. Pavlov Russian Medical Biological Herald. 26:305-316
Inhibition of Pglycoprotein transporter protein (ABCB1protein, Pgp) is a promising method to increase the effectiveness of pharmacotherapy in different pathologies: neoplastic diseases, epilepsy, cerebral circulation disorders. Pgp is a large transme