Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Aleksey V. Matveyenko"'
Autor:
Matthew R. Brown, Damien Laouteouet, Morgane Delobel, Orianne Villard, Christophe Broca, Gyslaine Bertrand, Anne Wojtusciszyn, Stéphane Dalle, Magalie A. Ravier, Aleksey V. Matveyenko, Safia Costes
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-12 (2022)
Abstract Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function, and survival through clearance of misfolded proteins and damaged organelles. Howe
Externí odkaz:
https://doaj.org/article/b8f90d9713164bc79d87bd9e85ebe040
Autor:
Zhongying Wang, Tatyana Gurlo, Aleksey V. Matveyenko, David Elashoff, Peiyu Wang, Madeline Rosenberger, Jason A. Junge, Raymond C. Stevens, Kate L. White, Scott E. Fraser, Peter C. Butler
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Using phasor-FLIM (Fluorescence Lifetime Imaging Microscopy), Wang et al. reveal differential usages of oxidative phosphorylation and glycolysis in living islet cells following glucose stimulation. This study suggests the applicability of FLIM as a d
Externí odkaz:
https://doaj.org/article/16706c9faa644994ba8974540e742fe0
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Our ever-changing modern environment is a significant contributor to the increased prevalence of many chronic diseases, and particularly, type 2 diabetes mellitus (T2DM). Although the modern era has ushered in numerous changes to our daily living con
Externí odkaz:
https://doaj.org/article/7071ef5e69254d55bf1fe613c02d333b
Autor:
Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression
Externí odkaz:
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
Autor:
Yaxi Zhu, Jason M. Tonne, Qian Liu, Claire A. Schreiber, Zhiguang Zhou, Kuntol Rakshit, Aleksey V. Matveyenko, Andre Terzic, Dennis Wigle, Yogish C. Kudva, Yasuhiro Ikeda
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 307-321 (2019)
Summary: Generation of functional β cells from pluripotent sources would accelerate diagnostic and therapeutic applications for diabetes research and therapy. However, it has been challenging to generate competent β cells with dynamic insulin-secre
Externí odkaz:
https://doaj.org/article/5560a206141740e1b439ccf39e142bc3
Autor:
Naureen Javeed, Tracy K. Her, Matthew R. Brown, Patrick Vanderboom, Kuntol Rakshit, Aoife M. Egan, Adrian Vella, Ian Lanza, Aleksey V. Matveyenko
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109613- (2021)
Summary: Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been shown to perturb β cell communication and function. Compelling
Externí odkaz:
https://doaj.org/article/f6142bb336574cc9a398c46f3da9ef28
Autor:
Jin Xu, Yun-Fang Jia, Subhasish Tapadar, Jessica D. Weaver, Idris O. Raji, Deeti J. Pithadia, Naureen Javeed, Andrés J. García, Doo-Sup Choi, Aleksey V. Matveyenko, Adegboyega K. Oyelere, Chong Hyun Shin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract β-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type 1 diabetes, we identified inhibitors of non-canonical IκB kinases (IKKs), TANK
Externí odkaz:
https://doaj.org/article/64e8697002f84880b24071507a486054
Publikováno v:
Physiology. 36:197-200
Autor:
Adrian Vella, Giuseppe De Nicolao, John G. Jones, Marcello C. Laurenti, James C. Andrews, Robert A. Rizza, Chiara Dalla Man, Aleksey V. Matveyenko, Cristina Barosa, Claudio Cobelli, Kent R. Bailey, Ron T. Varghese
Publikováno v:
J Clin Endocrinol Metab
Objective Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are characterized by insulin resistance. This has led to the suggestion that changes in insulin pulsatility directly impair insulin signaling. We sought to exa
Autor:
Aleksey V. Matveyenko, Kuntol Rakshit
Publikováno v:
Diabetes
Type 2 diabetes mellitus (T2DM) is characterized by β-cell dysfunction as a result of impaired glucose-stimulated insulin secretion (GSIS). Studies show that β-cell circadian clocks are important regulators of GSIS and glucose homeostasis. These ob