Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Aleksey G. Kazantsev"'
Autor:
Vanita Chopra, Luisa Quinti, Jinho Kim, Lorraine Vollor, K. Lakshmi Narayanan, Christina Edgerly, Patricia M. Cipicchio, Molly A. Lauver, Soo Hyuk Choi, Richard B. Silverman, Robert J. Ferrante, Steven Hersch, Aleksey G. Kazantsev
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1492-1497 (2012)
Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and invertebrate models of Parkinson’s disease and Huntington’s disease (HD). Here we report the in vivo efficacy of a brain-permeable SIRT2 inhibitor in two genetic
Externí odkaz:
https://doaj.org/article/05ad6c5569d5491bb7cc752d2f791b92
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life, such as cancer, diabetes, cardiovascular and neurodegenerative diseases. In mammals, there ar
Externí odkaz:
https://doaj.org/article/36e2f88a3a314677a652e228040309a7
Autor:
Aleksey G. Kazantsev, Tiago F. Outeiro
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Externí odkaz:
https://doaj.org/article/0642f9a86a54415596cb5a07da8c6e2d
Autor:
Tara Leigh Spires-Jones, Leora M Fox, Anete eRozkalne, Rose ePitstick, George A Carlson, Aleksey G. Kazantsev
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Tauopathies including tau-associated Frontotemporal dementia and Alzheimer’s disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute to cognitive decline. There are
Externí odkaz:
https://doaj.org/article/2e30408a73d141e98d63ef576c2e5813
Publikováno v:
Neurodegenerative Disease Management. 7:97-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2465d64d4419a9d5e7da64b0795d4996
https://doi.org/10.2217/nmt-2017-0011
https://doi.org/10.2217/nmt-2017-0011
Autor:
Maria Angulo-Ibanez, Johan Auwerx, Katrin F. Chua, William Giblin, David Gius, Leonard Guarente, Angela H. Guo, Marcia C. Haigis, Sylvana Hassanieh, Kathleen A. Hershberger, Matthew D. Hirschey, Shin-ichiro Imai, Alice E. Kane, Elena Katsyuba, Aleksey G. Kazantsev, Hening Lin, David B. Lombard, Sébastien Moniot, Raul Mostoslavsky, Tiago F. Outeiro, David A. Sinclair, Clemens Steegborn, Adam B. Stein, Éva M. Szegő, Robert A.H. van de Ven, Athanassios Vassilopoulos, Rui-Hong Wang, Wen Yang, Mitsukuni Yoshida, Weijie You
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43cec83b0e139b92c8d36f2a223b81f4
https://doi.org/10.1016/b978-0-12-813499-3.00018-6
https://doi.org/10.1016/b978-0-12-813499-3.00018-6
The family of mammalian sirtuin deacetylases is comprised of seven members (SIRT1–7). This chapter is focused on the biological and pathological role(s) of sirtuins in health and neurodegeneration. In the central nervous system, sirtuins are broadl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7e94fff4824bf8b62b3ac548b6d6ff
https://doi.org/10.1016/b978-0-12-813499-3.00013-7
https://doi.org/10.1016/b978-0-12-813499-3.00013-7
Autor:
Johnathan Nobles, Luisa Quinti, Hua Wang, Richard B. Silverman, Mohammad A. Khanfar, Aleksey G. Kazantsev
Publikováno v:
ACS Medicinal Chemistry Letters. 6:607-611
Inhibitors of sirtuin-2 (SIRT2) deacetylase have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology. The present study was directed at optimizing the potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c26c330d213a015db6db4e45ad0bfbd
https://doi.org/10.1021/acsmedchemlett.5b00075
https://doi.org/10.1021/acsmedchemlett.5b00075
Autor:
Colúm Connolly, Clemens Steegborn, Donald C. Lo, Albena T. Dinkova-Kostova, Andrew Snyder, Vanita Chopra, Alexei Degterev, Michael A. Schwarzschild, Cho Low, Ulrike Träger, Leslie M. Thompson, Michael J. Van Kanegan, James R. Miller, Matthew Fuszard, Ningzhe Zhang, Ellen Sapp, Susanta Samajdar, Lisa Meisel, Kimberly B. Kegel-Gleason, Petr Vodicka, Adelaide Tousley, Lisa M. Ellerby, David Llères, Sébastien Moniot, Aleksey G. Kazantsev, Steven M. Hersch, Lisa A. Crawford, Ross S. Stein, Sarah J. Tabrizi, Eranthie Weerapana, Vijay Potluri, Linda S. Kaltenbach, Ruth Farmer, Blair R. Leavitt, Maureen Higgins, Luisa Quinti, Marian DiFiglia, Sharadha Dayalan Naidu, Xiqun Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 23
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes. The present study has characterized a triaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bba6be10075b3b40875d35cd1e72bd7
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
Autor:
Prarthana Khanna, Anne B. Young, Luisa Quinti, Paolo Paganetti, Vanita Chopra, Aleksey G. Kazantsev, Steven M. Hersch, Rainer Kuhn
Publikováno v:
Journal of Huntington's Disease
Background: Modulation of gene transcription by HDAC inhibitors has been shown repeatedly to be neuroprotective in cellular, invertebrate, and rodent models of Huntington’s disease (HD). It has been difficult to translate these treatments to the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f598dbd6d0bddd675cd818e53012a9d3
https://pubmed.ncbi.nlm.nih.gov/27983565
https://pubmed.ncbi.nlm.nih.gov/27983565