Aulosirazoles B and C from the Cyanobacterium

Autor: Lydia J, Davis, Amanda C, Maldonado, Manead, Khin, Aleksej, Krunic, Joanna E, Burdette, Jimmy, Orjala

Publikováno v: J Nat Prod

The known solid-tumor-selective cytotoxin aulosirazole (1) was identified from bioactive extracts from the culture medium of the cyanobacterium Nostoc sp. UIC 10771. Here, we demonstrate that 1 induces the nuclear accumulation of FOXO3a in OVCAR3 usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecccccac37a6016c8fa19495ed6136a0
https://pubmed.ncbi.nlm.nih.gov/35100504

A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges**

Autor: Jennifer Diaz-Espinosa, Laura M. Sanchez, Aleksej Krunic, Roberto G. S. Berlinck, Jimmy Orjala, Yitao Dai, Antonio G. Ferreira, Laura P. Ióca, Camila M. Crnkovic, Sylvia Kunakom, Alessandra S. Eustáquio

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Angew Chem Int Ed Engl
Angewandte Chemie (International ed. in English), vol 60, iss 29

Although swarming motility and biofilms are opposed collective behaviors, both contribute to bacterial survival and host colonization. Pseudovibrio bacteria have attracted attention because they are part of the microbiome of healthy marine sponges. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dd92d19174728805a4a38268fbc8ca
https://doi.org/10.1002/ange.202017320

Scytodecamide from the Cultured Scytonema sp. UIC 10036 Expands the Chemical and Genetic Diversity of Cyanobactins

Autor: Jana Braesel, Alessandra S. Eustáquio, Aleksej Krunic, Jimmy Orjala, Camila M. Crnkovic

Publikováno v: Chembiochem

Cyanobactins are a large family of cyanobacterial ribosomally synthesized and post-translationally modified peptides (RiPPs) often associated with biological activities, such as cytotoxicity, antiviral, and antimalarial activities. They are tradition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c4e117940850a9bef5e6126e3678a3
https://doi.org/10.1002/cbic.201900511

Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484

Autor: Peter Sullivan, Aleksej Krunic, Joanna E. Burdette, Jimmy Orjala

Publikováno v: J Antibiot (Tokyo)

Two laxaphycin type-B cyclic dodecapeptides, laxaphycins B5 and B6, were obtained from UIC 10484, a freshwater cf. Phormidium sp. Analysis using the 16S rRNA sequence found UIC 10484 to clade with UIC 10045, a known laxaphycin type-A and -B producer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6f32cbfcaa1634d305fc9d81f67f55
https://europepmc.org/articles/PMC7338234/

Ribocyclophanes A–E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria

Autor: Steven M. Swanson, Bernard D. Santarsiero, Qi Shen, Daniel S. May, Jimmy Orjala, Joanna E. Burdette, Aleksej Krunic, Hahk Soo Kang

Publikováno v: Journal of Natural Products. 81:572-578

The cell extracts of two cultured freshwater Nostoc spp., UIC 10279 and UIC 10366, both from the suburbs of Chicago, showed antiproliferative activity against MDA-MB-231 and MDA-MB-435 cancer cell lines. Bioassay-guided fractionation led to the isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8237719c063d97567f819c62417478
https://doi.org/10.1021/acs.jnatprod.7b00954