Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aleksei Kabedev"'
Autor:
Aleksei Kabedev, Xuezhi Zhuo, Donglei Leng, Vito Foderà, Min Zhao, Per Larsson, Christel A. S. Bergström, Korbinian Löbmann
Publikováno v:
Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing mechanisms of β-lactoglobulin in amorphous solid dispersions of indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922-3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397
Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922–3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397
Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922–3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397
Proteins, and in particular whey proteins, have recently been introduced as a promising excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of the approach, the molecular mechanisms behind the stabilization of t
Molecular Dynamics Simulations as a Tool to Understand Drug Solubilization in Pharmaceutical Systems
Publikováno v:
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering ISBN: 9780124095472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba1a8b861cc66ce95b121a8bd5595b4d
https://doi.org/10.1016/b978-0-12-821978-2.00114-8
https://doi.org/10.1016/b978-0-12-821978-2.00114-8
Autor:
Ann-Christin, Jacobsen, Aleksei, Kabedev, Patrick D, Sinko, Johan E, Palm, Christel A S, Bergström, Alexandra, Teleki
Publikováno v:
Drug delivery and translational research.
Lipid-based formulations (LBFs) are used by the pharmaceutical industry in oral delivery systems for both poorly water-soluble drugs and biologics. Digestibility is key for the performance of LBFs and in vitro lipolysis is commonly used to compare th
Autor:
Vladimir Lobaskin, Aleksei Kabedev
Publikováno v:
Nanomedicine (London, England). 17(13)
Glycocalyx has a great impact on the accessibility of the endothelial cell membranes. Although the specific interactions play a crucial role in cross-membrane solute transport, nonspecific interactions cannot be neglected. In this work, we used compu
Autor:
Ann-Christin Jacobsen, Aleksei Kabedev, Patrick D. Sinko, Johan E. Palm, Christel A. S. Bergström, Alexandra Teleki
Publikováno v:
Drug Delivery and Translational Research
Lipid-based formulations (LBFs) are used by the pharmaceutical industry in oral delivery systems for both poorly water-soluble drugs and biologics. Digestibility is key for the performance of LBFs and in vitro lipolysis is commonly used to compare th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46241416dc016a93d44ccd3a7d29f8a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490612
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490612
Autor:
Kang-Cheng Liu, Hudson Pace, Elin Larsson, Shakhawath Hossain, Aleksei Kabedev, Ankita Shukla, Vanessa Jerschabek, Jagan Mohan, Christel A. S. Bergström, Marta Bally, Christian Schwieger, Madlen Hubert, Richard Lundmark
Caveolae are small plasma membrane invaginations, important for control of membrane tension, signaling cascades, and lipid sorting. The caveola coat protein Cavin1 is essential for shaping such high curvature membrane structures. Yet, a mechanistic u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef227399a9f2a93630454ba7f0588904
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482694
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482694
Autor:
Shakhawath Hossain, Albin Parrow, Aleksei Kabedev, Rosita Carolina Kneiszl, Yuning Leng, Per Larsson
Publikováno v:
Processes; Volume 10; Issue 1; Pages: 29
Processes, Vol 10, Iss 29, p 29 (2022)
Processes, Vol 10, Iss 29, p 29 (2022)
Permeation enhancers (PEs) can increase the bioavailability of drugs. The mechanisms of action of these PEs are complex, but, typically, when used for oral administration, they can transiently induce the alteration of trans- and paracellular pathways
Autor:
Khadijah Edueng, Aleksei Kabedev, Alyssa Ekdahl, Denny Mahlin, John Baumann, Deanna Mudie, Christel A.S. Bergström
Publikováno v:
International journal of pharmaceutics. 613
Robust and reliable in vivo performance of medicines based on amorphous solid dispersions (ASDs) depend on maintenance of physical stability and efficient supersaturation. However, molecular drivers of these two kinetic processes are poorly understoo
Autor:
Kang-cheng Liu, Hudson Pace, Elin Larsson, Shakhawath Hossain, Aleksei Kabedev, Ankita Shukla, Vanessa Jerschabek, Jagan Mohan, Christel A. S. Bergström, Marta Bally, Christian Schwieger, Madlen Hubert, Richard Lundmark
Caveolae are small plasma membrane invaginations, important for control of membrane tension, signaling cascades and lipid sorting. The caveolae coat protein Cavin1 is essential for shaping such high curvature membrane structures. Yet, a mechanistic u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5eb3b521e34f3300c34ed9644e7520b
https://doi.org/10.1101/2021.03.23.436578
https://doi.org/10.1101/2021.03.23.436578
Molecular transport mechanisms of poorly soluble hydrophobic drug compounds to lipid membranes were investigated using molecular dynamics (MD) simulations. The model compound danazol was used to investigate the mechanism(s) by which bile micelles del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f97df2009cb45ce21387439cfe4fb32
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431581
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431581