3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII

Autor: Aleksandrs Pustenko, Anastasija Balašova, Alessio Nocentini, Claudiu T. Supuran, Raivis Žalubovskis

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 216-224 (2023)

The synthesis of 3H-1,2-benzoxaphosphepine 2-oxides and evaluation of their inhibitory activity against human carbonic anhydrase (hCA) isoforms I, II, IX, and XII are described. The target compounds were obtained via a concise synthesis from commerci

Externí odkaz: https://doaj.org/article/f21ae4aebe2a4ab681319cf3e3aae23d

Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors

Autor: Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Ahmed Alafeefy, Mikhail Krasavin, Raivis Žalubovskis, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 245-254 (2020)

A new series of homosulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) possessing various substitution patterns and moieties in the 7, 8 or 9 position of the heterocylic ring were prepared by original procedures and investigated for the inhibition

Externí odkaz: https://doaj.org/article/d8f6b63729cc40638832b17e7b77b9b3

7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors

Autor: Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Mikhail Krasavin, Raivis Žalubovskis, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 650-656 (2020)

A series of 3H-1,2-benzoxathiepine 2,2-dioxides incorporating 7-acylamino moieties were obtained by an original procedure starting from 5-nitrosalicylaldehyde, which was treated with propenylsulfonyl chloride followed by Wittig reaction of the bis-ol

Externí odkaz: https://doaj.org/article/e73ee7e3ebe44e45a7623d02d9ebcf72

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

Autor: Aleksandrs Pustenko, Dmitrijs Stepanovs, Raivis Žalubovskis, Daniela Vullo, Andris Kazaks, Janis Leitans, Kaspars Tars, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 767-775 (2017)

A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original syn

Externí odkaz: https://doaj.org/article/c3401a592ad34707874021d7e92f32cf

The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

Autor: Paola Gratteri, Raivis Žalubovskis, Alessio Nocentini, Alessandro Bonardi, Claudiu T. Supuran, I. V. Vozny, Aleksandrs Pustenko

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1011-1020 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry

The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII). Furagin exhibited good hCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa1bd708bf1d0b9f35dede26bf90872
https://doaj.org/article/10dedb54271a4f32bea62d1cae407b94