Výsledky vyhledávání - "Aleksandra Wojtala"

Akademický článek

The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.

Autor: Olga Alster, Anna Bielak-Zmijewska, Grazyna Mosieniak, Maria Moreno-Villanueva, Wioleta Dudka-Ruszkowska, Aleksandra Wojtala, Monika Kusio-Kobiałka, Zbigniew Korwek, Alexander Burkle, Katarzyna Piwocka, Jan K Siwicki, Ewa Sikora

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104964 (2014)

Nibrin plays an important role in the DNA damage response (DDR) and DNA repair. DDR is a crucial signaling pathway in apoptosis and senescence. To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and

Externí odkaz: https://doaj.org/article/113bedff0d2a48deac13c1fd2b904068

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NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4

Autor: Merel J W, Adjobo-Hermans, Ria, de Haas, Peter H G M, Willems, Aleksandra, Wojtala, Sjenet E, van Emst-de Vries, Jori A, Wagenaars, Mariel, van den Brand, Richard J, Rodenburg, Jan A M, Smeitink, Leo G, Nijtmans, Leonid A, Sazanov, Mariusz R, Wieckowski, Werner J H, Koopman

Publikováno v: Biochimica et biophysica acta. Bioenergetics. 1861(8)

Mutations in NDUFS4, which encodes an accessory subunit of mitochondrial oxidative phosphorylation (OXPHOS) complex I (CI), induce Leigh syndrome (LS). LS is a poorly understood pediatric disorder featuring brain-specific anomalies and early death. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17f057b315e2d62d5f878aaa0c00d4c5
https://pubmed.ncbi.nlm.nih.gov/32335026

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NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-) mice and Leigh syndrome patients: A stabilizing role for NDUFAF2

Autor: Leo G.J. Nijtmans, Mariël A.M. van den Brand, Jori A. L. Wagenaars, Leonid A. Sazanov, Werner J.H. Koopman, Jan A.M. Smeitink, Merel J. W. Adjobo-Hermans, Sjenet E. van Emst-de Vries, Mariusz R. Wieckowski, Richard J. Rodenburg, Peter H.G.M. Willems, Aleksandra Wojtala, Ria de Haas

Publikováno v: Biochimica et Biophysica Acta. Bioenergetics, 1861
Biochimica et Biophysica Acta. Bioenergetics, 1861, 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeb3235af78648702b370eecd47a8b4
https://hdl.handle.net/2066/220251

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Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes

Autor: Małgorzata Partyka, Mariusz R. Wieckowski, Monika Prill, Alain Sewer, Karolina Drabik, Julia Hoeng, Bernadeta Michalska, Jędrzej Szymański, Paulina Patalas-Krawczyk, Marco van der Toorn, Stephanie Johne, Jarosław Walczak, Jerzy Duszyński, Joanna Szczepanowska, Aleksandra Wojtala, Dominika Malinska, Manuel C. Peitsch, Karsta Luettich

Publikováno v: Food and Chemical Toxicology. 115:1-12

Mitochondrial dysfunction caused by cigarette smoke is involved in the oxidative stress-induced pathology of airway diseases. Reducing the levels of harmful and potentially harmful constituents by heating rather than combusting tobacco may reduce mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef086138bacf4d604ff36cddb887a5fb
https://doi.org/10.1016/j.fct.2018.02.013

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Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway

Autor: Aleksandra Wojtala, Vilma A. Sardão, Maciej Pronicki, Paweł Kowalski, Jerzy Duszyński, Mariusz R. Wieckowski, Joanna Szczepanowska, Agnieszka Karkucinska-Wieckowska

Publikováno v: Mitochondrion. 37:62-79

The mitochondrial respiratory chain, and in particular, complex I, is a major source of reactive oxygen species (ROS) in cells. Elevated levels of ROS are associated with an imbalance between the rate of ROS formation and the capacity of the antioxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f762356fd8804beec5f1627900a1433
https://doi.org/10.1016/j.mito.2017.07.002

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p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts

Autor: Aleksandra Wojtala, Paulo J. Oliveira, Mariusz R. Wieckowski, Ignacio Vega-Naredo, Susana F. Sampaio, Ana F. Branco

Publikováno v: Archives of Toxicology. 90:1669-1684

The adaptor protein p66Shc modulates cellular redox status integrating oxidative stress with mitochondrial stress responses. Upon oxidative stress, p66Shc is translocated to mitochondria or mitochondria-associated membranes in a multi-step process, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c757948850af90a6600a6c36b2da5d
https://doi.org/10.1007/s00204-015-1583-9

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Cardiac mitochondrial dysfunction during hyperglycemia—The role of oxidative stress and p66Shc signaling

Autor: Paulo J. Oliveira, Magdalena Lebiedzinska, Mariusz R. Wieckowski, Agnieszka Karkucinska-Wieckowska, Piero Portincasa, Cátia V. Diogo, Paolo Pinton, Jerzy Duszyński, Aleksandra Wojtala, Jan M. Suski, Maciej Pronicki

Publikováno v: The International Journal of Biochemistry & Cell Biology. 45:114-122

Diabetes mellitus is a chronic disease caused by a deficiency in the production of insulin and/or by the effects of insulin resistance. Insulin deficiency leads to hyperglycemia which is the major initiator of diabetic cardiovascular complications es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1acddee81330a9642d0e514fc6ee54
https://doi.org/10.1016/j.biocel.2012.07.004

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Carvedilol and antioxidant proteins in a type I diabetes animal model

Autor: Aleksandra Wojtala, Magdalena Lebiedzinska-Arciszewska, Mariusz R. Wieckowski, Paulo J. Oliveira, Cláudia M. Deus, Cátia V. Diogo

Publikováno v: European journal of clinical investigation. 47(1)

Background Patients with diabetes are at a high risk of developing both micro- and macrovascular disease. Hyperglycaemia seems to be the main factor in the pathogenesis of diabetic cardiomyopathy, often based on increased oxidative stress. Carvedilol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf311e573786dc7320e4ad92a84883ab
https://pubmed.ncbi.nlm.nih.gov/27805735

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A candidate-modified-risk tobacco product has reduced effects on mitochondrial function in airway epithelial cells compared to combustible cigarettes

Autor: Małgorzata Partyka, Marco van der Toorn, Karsta Luettich, Mariusz R. Wieckowski, Jarosław Walczak, Julia Hoeng, Monika Pril, Bernadeta Michalska, Stephanie Johne, Manuel C. Peitsch, Jędrzej Szymański, Karolina Drabik, Joanna Szczepanowska, Paulina Patalas-Krawczyk, Jerzy Duszyński, Aleksandra Wojtala, Dominika Malinska

Publikováno v: Toxicology Letters. 280:S261-S262

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78056e5cafbfe5cdede403bbb24bc766
https://doi.org/10.1016/j.toxlet.2017.07.928

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Methods to monitor ROS production by fluorescence microscopy and fluorometry

Autor: Aleksandra, Wojtala, Massimo, Bonora, Dominika, Malinska, Paolo, Pinton, Jerzy, Duszynski, Mariusz R, Wieckowski

Publikováno v: Methods in enzymology. 542

Mitochondria are considered one of the main sources of reactive oxygen species (ROS). The overgeneration of ROS can evoke an intracellular state of oxidative stress, leading to permanent cell damage. Thus, the intracellular accumulation of ROS may no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d92f3e533af48964e10a7ae801ff95f
https://pubmed.ncbi.nlm.nih.gov/24862270

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