Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Aleksandra V. Sen′kova"'
Autor:
Kirill V. Odarenko, Aleksandra V. Sen’kova, Oksana V. Salomatina, Oleg V. Markov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Soloxolone amides are semisynthetic triterpenoids that can cross the blood-brain barrier and inhibit glioblastoma growth both in vitro and in vivo. Here we investigate the impact of these compounds on processes associated with glioblastoma invasivene
Externí odkaz:
https://doaj.org/article/8bda56d571fa47af9a22c1eedf902d68
Autor:
Khetam Sounbuli, Ludmila A. Alekseeva, Aleksandra V. Sen’kova, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova
Publikováno v:
Biomedicines, Vol 12, Iss 11, p 2571 (2024)
Background/Objectives: Neutrophils have recently gained significant attention due to their heterogeneity in tumor settings. The gene expression profiles of neutrophils from different tumor types are of great interest. Murine splenic neutrophils refle
Externí odkaz:
https://doaj.org/article/440b150f37114835ba98ad8a46fdf6e6
Autor:
Ivan V. Chernikov, Irina K. Bachkova, Aleksandra V. Sen’kova, Mariya I. Meschaninova, Innokenty A. Savin, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Cells, Vol 13, Iss 9, p 767 (2024)
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of siRNA have been primarily limited to liver diseases, while achievements in delivery methods are
Externí odkaz:
https://doaj.org/article/df86cd36ee1a45d0b8013056b41765d0
Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA
Autor:
Ali Bishani, Darya M. Makarova, Elena V. Shmendel, Mikhail A. Maslov, Aleksandra V. Sen‘kova, Innokenty A. Savin, Daniil V. Gladkikh, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2184 (2023)
In this study, the impact of different delivery systems on the cytokine-inducing, antiproliferative, and antitumor activities of short immunostimulatory double-stranded RNA (isRNA) was investigated. The delivery systems, consisting of the polycationi
Externí odkaz:
https://doaj.org/article/59a02d77ecb24d2b8dd56541fe8cdb95
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 50-61 (2020)
Tumor-associated cell-free DNAs (cfDNAs) are found to play some important roles at different stages of tumor progression; they are involved in the transformation of normal cells and contribute to tumor migration and invasion. DNase I is considered a
Externí odkaz:
https://doaj.org/article/c073b435162f49aabf5462aa84315286
Autor:
Oleg V. Markov, Aleksandra V. Sen’kova, Islam S. Mohamed, Elena V. Shmendel, Mikhail A. Maslov, Anastasiya L. Oshchepkova, Evgeniy V. Brenner, Nadezhda L. Mironova, Marina A. Zenkova
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2542 (2022)
Cell-free antitumor vaccines represent a promising approach to immunotherapy of cancer. Here, we compare the antitumor potential of cell-free vaccines based on microvesicles derived from dendritic cells (DCs) with DC- and cationic-liposome-based vacc
Externí odkaz:
https://doaj.org/article/eb3ad4ee0c254b07bea709de01437fb6
Publikováno v:
Cancer Reports, Vol 4, Iss 4, Pp n/a-n/a (2021)
Abstract Background Acute myeloid leukemia (AML) is the most common acute leukemia in adults, and chemotherapy remains the most commonly used treatment approach for this group of hematological disorders. Drug resistance is one of the predictors of un
Externí odkaz:
https://doaj.org/article/329dde0b42884e6f8795c1f0369637ee
Autor:
Andrey V. Markov, Anna A. Ilyina, Oksana V. Salomatina, Aleksandra V. Sen’kova, Alina A. Okhina, Artem D. Rogachev, Nariman F. Salakhutdinov, Marina A. Zenkova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 603 (2022)
The modification of natural or semisynthetic triterpenoids with amines can be explored as a promising strategy for improving their pharmacological properties. Here, we report the design and synthesis of 11 novel amide derivatives of soloxolone methyl
Externí odkaz:
https://doaj.org/article/0e236ee1d7d643448b1ea349a90beec2
Autor:
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1173 (2022)
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the r
Externí odkaz:
https://doaj.org/article/3f3cae006e2e4858bf3bff7765acd96c
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1017 (2022)
Asthma is a heterogeneous pulmonary disorder, the progression and chronization of which leads to airway remodeling and fibrogenesis. To understand the molecular mechanisms of pulmonary fibrosis development, key genes forming the asthma-specific regul
Externí odkaz:
https://doaj.org/article/db6c615ac318438cafbe81a1f3a41be4