Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Aleksandra S. Kołodziejczyk"'
Autor:
Izabela Behrendt, Martyna Prądzińska, Roman A. Zubarev, Paulina Czaplewska, Aleksandra S. Kołodziejczyk, Juan Astorga-Wells, Sylwia Rodziewicz-Motowidło, Aleksandr Manoilov
Publikováno v:
Amino Acids
Human cystatin C (hCC) is a small cysteine protease inhibitor whose oligomerization by propagated domain swapping is linked to certain neurological disorders. One of the ways to prevent hCC dimerization and fibrillogenesis is to enable its interactio
Autor:
Aleksandra S. Kołodziejczyk, Martyna Maszota, Jerzy Ciarkowski, Paulina Czaplewska, Sylwia Rodziewicz-Motowidło, Natalia Karska, Marta Spodzieja
Publikováno v:
Journal of Molecular Recognition. 28:413-426
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose concentration in serum increases markedly following a number of chronic inflammatory and neoplastic diseases. Prolonged high SAA level may give rise to reactive systemic amyloid A (
Autor:
Sylwia Rodziewicz-Motowidło, Aneta Szymańska, Aleksandra S. Kołodziejczyk, Susanna L. Lundström, Franciszek Kasprzykowski, Marta Spodzieja, Roman A. Zubarev, Paulina Czaplewska, Martyna Prądzińska, Izabela Behrendt
Publikováno v:
Journal of molecular recognition : JMR. 31(4)
Amyloid formation is associated with a number of neurodegenerative diseases that affect the independence and quality of life of aging populations. One of rather atypical, occurring at a young age amyloidosis is hereditary cystatin C amyloid angiopath
Autor:
Marta Spodzieja, Aneta Szymańska, Monika Rafalik, Paulina Czaplewska, Aleksandra S. Kołodziejczyk
Publikováno v:
Journal of Molecular Recognition. 26:415-425
Secondary amyloid A (AA) amyloidosis is an important complication of some chronic inflammatory diseases, primarily rheumatoid arthritis (RA). It is a serious, potentially life-threatening disorder caused by the deposition of AA fibrils, which are der
Autor:
Marta, Spodzieja, Katarzyna, Kalejta, Aleksandra S, Kołodziejczyk, Martyna, Maszota-Zieleniak, Sylwia, Rodziewicz-Motowidło, Wioletta, Żmudzińska, Paulina, Czaplewska
Publikováno v:
Journal of molecular recognition : JMR. 30(2)
Cystatin C originally identified as a cysteine proteases inhibitor has a broad spectrum of biological roles ranging from inhibition of extracellular cysteine protease activities, bone resorption, and modulation of inflammatory responses to stimulatio
Autor:
Sylwia Rodziewicz-Motowidło, Roman A. Zubarev, Martyna Prądzińska, Aleksandra S. Kołodziejczyk, Paulina Czaplewska, Marta Spodzieja, Susanna L. Lundström, Izabela Behrendt, Aneta Szymańska, Katarzyna Macur
Publikováno v:
Amino acids. 48(11)
Hereditary cystatin C amyloid angiopathy (HCCAA) is a severe neurodegenerative disorder related to the point mutation in cystatin C gene resulting in human cystatin C (hCC) L68Q variant. One of the potential immunotherapeutic approaches to HCCAA trea
Autor:
Sylwia Rodziewicz-Motowidło, Martyna Prądzińska, Aneta Szymańska, Izabela Behrendt, Aleksandra S. Kołodziejczyk, Paulina Czaplewska, Marta Spodzieja
Publikováno v:
Amino acids. 48(7)
Human cystatin C (hCC), like many other amyloidogenic proteins, dimerizes and possibly makes aggregates by subdomain swapping. Inhibition of the process should suppress the fibrillogenesis leading to a specific amyloidosis (hereditary cystatin C amyl
Autor:
Piotr Stefanowicz, Zbigniew Szewczuk, Martyna Maszota, Anders Grubb, Aleksandra S. Kołodziejczyk, Aneta Szymańska, Martyna Prądzińska, Paulina Czaplewska, Marta Spodzieja
Publikováno v:
Journal of Molecular Recognition. 25:513-524
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose natural role seems to be participation in many physiologic and pathological processes. Prolonged increased SAA level in a number of chronic inflammatory and neoplastic diseases give
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 88:817-827
The title compounds were obtained each time as a mixture of the cis-S-methyl and trans-S-methyl diastereomers by methylation of the respectively cis- and trans-diketopiperazines (DKP), c/L-Phe, L-Thz/ and c/D-Phe, L-Thz/ (Thz = 4-thiazolidine-2-carbo
Publikováno v:
Bulletin des Sociétés Chimiques Belges. 90:785-802
The solvolysis of cis− and trans-S-methylthiazolidinium phenylalanine cyclic dipeptides (diketopiperazines) in H2O (D2O), CH3OH, CD3OD:D2O and DCOOD has been studied. Ring opening of the Thz rings occurs (i) exclusively at the δ-position in the tr