Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Aleksandra Pekowska"'
Autor:
Eryk Duński, Aleksandra Pękowska
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The unique qualities of the human brain are a product of a complex evolutionary process. Evolution, famously described by François Jacob as a “tinkerer,” builds upon existing genetic elements by modifying and repurposing them for new functions.
Externí odkaz:
https://doaj.org/article/caee1702eb0843afb2d4ba4cd8dcde69
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 765 (2021)
Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives. NDs have complex etiologie
Externí odkaz:
https://doaj.org/article/e9d0bdf0536a48f9bbcb56b48c25bd4c
Autor:
Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Victor Bass, Lauren Reich, Chen Yao, Hong-Wei Sun, Stephen R. Brooks, Kan Jiang, Vijayaraj Nagarajan, Rachael Phillips, Yohei Mikami, Caleb A. Lareau, Yuka Kanno, Dragana Jankovic, Martin J. Aryee, Aleksandra Pekowska, Yasmine Belkaid, John O’Shea, Han-Yu Shih
Publikováno v:
SSRN Electronic Journal.
Autor:
Dragana Jankovic, Chen Yao, Alan Sher, Franziska Petermann, Catrina A. Johnson, Aleksandra Pekowska, William H. Hudson, Hong-Wei Sun, Yuka Kanno, Han-Yu Shih, Stephen R. Brooks, Kentner Singleton, Alejandro V. Villarino, Kan Jiang, Rama Akondy, John J. O'Shea, Rafael Casellas, Rafi Ahmed
Publikováno v:
Mol Cell
Summary Interferon gamma (IFN-γ), critical for host defense and tumor surveillance, requires tight control of its expression. Multiple cis-regulatory elements exist around Ifng along with a non-coding transcript, Ifng-as1 (also termed NeST). Here, w
Autor:
Wibke Schwarzer, Wolfgang Huber, Nezar Abdennur, Christian H. Haering, François Spitz, Aleksandra Pekowska, Shaltiel Ia, Leonid A. Mirny
SummaryCondensin complexes have been proposed to play a prominent role in interphase chromatin organization and control of gene expression. Here, we report that the deletion of the central condensin II kleisin subunit Ncaph2 in differentiated mouse h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb035c33e4b301be422c37d3993b01fc
Autor:
Anton Goloborodko, Geoffrey Fudenberg, Nuno A. Fonseca, Nezar Abdennur, Christian H. Haering, François Spitz, Aleksandra Pekowska, Yann Loe-Mie, Leonid A. Mirny, Wolfgang Huber, Wibke Schwarzer
Publikováno v:
Nature
Nature, 2017, 551 (7678), pp.51-56. ⟨10.1038/nature24281⟩
Nature, Nature Publishing Group, 2017, 551 (7678), pp.51-56. ⟨10.1038/nature24281⟩
Nature, 2017, 551 (7678), pp.51-56. ⟨10.1038/nature24281⟩
Nature, Nature Publishing Group, 2017, 551 (7678), pp.51-56. ⟨10.1038/nature24281⟩
International audience; Imaging and chromosome conformation capture studies have revealed several layers of chromosome organization, including segregation into megabase-sized active and inactive compartments, and partitioning into sub-megabase domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00b65cfc9b3d783076ade520d6d6e2d
https://hal-pasteur.archives-ouvertes.fr/pasteur-02873504
https://hal-pasteur.archives-ouvertes.fr/pasteur-02873504
Autor:
Aleksandra Pekowska, Fabian Grubert, Wolfgang Huber, Michael Snyder, Jonathan K. Pritchard, Anshul Kundaje, Carlos Bustamante, Ghia Euskirchen, Judith B. Zaugg, Lars M. Steinmetz, Peyton Greenside, Rohith Srivas, Oana Ursu, Nastaran Heidari, Doug H. Phanstiel, Alicia R. Martin, Damek V. Spacek, Maya Kasowski
Publikováno v:
Cell. 162(5):1051-1065
SummaryDeciphering the impact of genetic variants on gene regulation is fundamental to understanding human disease. Although gene regulation often involves long-range interactions, it is unknown to what extent non-coding genetic variants influence di
Autor:
Wolfgang Huber, Aleksandra Pekowska, Anton Goloborodko, Wibke Schwarzer, Christian H. Haering, Nuno A. Fonseca, Nezar Abdennur, Yann Loe-Mie, François Spitz, Geoffrey Fudenberg, Leonid A. Mirny
The three-dimensional organization of chromosomes is tightly related to their biological function 1. Both imaging and chromosome conformation capture studies have revealed several layers of organization 2-4: segregation into active and inactive compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8023038aa400fb054cad5e863744a5c1
https://doi.org/10.1101/094185
https://doi.org/10.1101/094185
Autor:
Aleksandra Pekowska, Felix A. Klein, Bernd Klaus, Nathalie Daigle, Paul Bertone, Wolfgang Huber, Małgorzata Oleś, Jan Ellenberg, Rafael Casellas, Wanqing Xiang, Lars M. Steinmetz, Jacqueline Severino
Publikováno v:
Cell Systems. 7:482-495.e10
Summary The genome of pluripotent stem cells adopts a unique three-dimensional architecture featuring weakly condensed heterochromatin and large nucleosome-free regions. Yet, it is unknown whether structural loops and contact domains display characte
Publikováno v:
Seminars in Immunology
Seminars in Immunology, 2010, 22 (6), pp.330-6. ⟨10.1016/j.smim.2010.07.002⟩
Seminars in Immunology, Elsevier, 2010, 22 (6), pp.330-6. ⟨10.1016/j.smim.2010.07.002⟩
Seminars in Immunology, 2010, 22 (6), pp.330-6. ⟨10.1016/j.smim.2010.07.002⟩
Seminars in Immunology, Elsevier, 2010, 22 (6), pp.330-6. ⟨10.1016/j.smim.2010.07.002⟩
International audience; V(D)J recombination assembles antigen receptor genes from germline V, D and J segments during lymphocyte development. In αβT-cells, this leads to the subsequent expression of T-cell receptor (TCR) β and α chains. Generally