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Akademický článek
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Autor:
Dorota Dudek, Emilia Dzien, Joanna Watly, Agnieszka Matera-Witkiewicz, Aleksandra Mikolajczyk, Agata Hajda, Joanna Olesiak-Banska, Magdalena Rowinska-Zyrek
The antimicrobial properties of amylin, a polypeptide secreted by the pancreas, are far less known than its antidiabetic function. Among the studied amylin analogues, the coordination of zinc(II) enhances the antifungal properties of pramlintide, a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aafa3465d1e3a02f9ab48739c4909ac3
https://doi.org/10.21203/rs.3.rs-1954176/v1
https://doi.org/10.21203/rs.3.rs-1954176/v1
Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity
Autor:
Dorota Dudek, Emilia Dzień, Joanna Wątły, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Agata Hajda, Joanna Olesiak-Bańska, Magdalena Rowińska-Żyrek
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The antimicrobial properties of amylin, a 37-amino acid peptide hormone, co-secreted with insulin from the pancreas, are far less known than its antidiabetic function. We provide insight into the bioinorganic chemistry of amylin analogues, s
Externí odkaz:
https://doaj.org/article/fe1dba4466b14709ab3c0b63075bc8bd
Publikováno v:
Crystals, Vol 13, Iss 8, p 1197 (2023)
Histidine triad nucleotide-binding protein 1 (HINT1) is the oldest and most widely distributed branch of the histidine triad superfamily of proteins. The HINT1 protein plays an important role in various biological processes and has been found in many
Externí odkaz:
https://doaj.org/article/53bd5ead9e8d45638faead6eea2aee42
Publikováno v:
Applied Sciences, Vol 13, Iss 4, p 2358 (2023)
(1) Background: The aim of this study was to identify the degradation product of ramipril (RAM) formed under dry air and to verify its potential modes of carcinogenicity. We intended to check whether its formation and presence in final dosage forms c
Externí odkaz:
https://doaj.org/article/b3a51945def64ae4833556b7ef655f33
Autor:
Marcin Stolarczyk, Agnieszka Matera-Witkiewicz, Aleksandra Wolska, Magdalena Krupińska, Aleksandra Mikołajczyk, Anna Pyra, Iwona Bryndal
Publikováno v:
Materials, Vol 14, Iss 22, p 6916 (2021)
Pyrimidine displays a wide array of bioactivities, and thence, it is still considered a potent unit of new drug research. Its derivative, 5-hydroxymethylpyrimidine, can be found as a scaffold of nontypical nitrogen bases in DNA and as a core of some
Externí odkaz:
https://doaj.org/article/68f751a1eae340b89839a40e4edb3d00
Autor:
Marcin Stolarczyk, Aleksandra Wolska, Aleksandra Mikołajczyk, Iwona Bryndal, Jerzy Cieplik, Tadeusz Lis, Agnieszka Matera-Witkiewicz
Publikováno v:
Molecules, Vol 26, Iss 8, p 2296 (2021)
Enterococcus faecalis is known as a significant nosocomial pathogen due to its natural resistance to many antibacterial drugs. Moreover, it was found that E. faecalis infection causes inflammation, production of reactive oxygen species, and DNA damag
Externí odkaz:
https://doaj.org/article/020c3cbe33a44f7fae7bd9bb2a9683a6