Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Aleksandra M. Walczak"'
Autor:
Christoph Kreer, Cosimo Lupo, Meryem S. Ercanoglu, Lutz Gieselmann, Natanael Spisak, Jan Grossbach, Maike Schlotz, Philipp Schommers, Henning Gruell, Leona Dold, Andreas Beyer, Armita Nourmohammad, Thierry Mora, Aleksandra M. Walczak, Florian Klein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent infection. Their induction by vaccination is therefore a major goal. However, in contrast to antibodies that neutralize other pathogens, HIV-1-specific bN
Externí odkaz:
https://doaj.org/article/e900725c8c9741e5a635d16c5aac862f
Autor:
Jos Urbanus, Jason Cosgrove, Joost B. Beltman, Yuval Elhanati, Rafael A. Moral, Cecile Conrad, Jeroen W. van Heijst, Emilie Tubeuf, Arno Velds, Lianne Kok, Candice Merle, Jens P. Magnusson, Léa Guyonnet, Jonas Frisén, Silvia Fre, Aleksandra M. Walczak, Thierry Mora, Heinz Jacobs, Ton N. Schumacher, Leïla Perié
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their regenerative capacity. However, HSPC
Externí odkaz:
https://doaj.org/article/59862cc7f88545bf963a5cd524bcd9f4
Autor:
Xiaowen Chen, Maciej Winiarski, Alicja Puścian, Ewelina Knapska, Aleksandra M. Walczak, Thierry Mora
Publikováno v:
Physical Review X, Vol 13, Iss 4, p 041053 (2023)
Large interacting systems in biology often exhibit emergent dynamics, such as coexistence of multiple timescales, manifested by fat tails in the distribution of waiting times. While existing tools in statistical inference, such as maximum entropy mod
Externí odkaz:
https://doaj.org/article/1f103ac0e0704ab9bfefbcb752226ebb
Autor:
Kamesh Krishnamurthy, Ann M. Hermundstad, Thierry Mora, Aleksandra M. Walczak, Vijay Balasubramanian
Publikováno v:
Frontiers in Computational Neuroscience, Vol 16 (2022)
Animals smelling in the real world use a small number of receptors to sense a vast number of natural molecular mixtures, and proceed to learn arbitrary associations between odors and valences. Here, we propose how the architecture of olfactory circui
Externí odkaz:
https://doaj.org/article/eda9b2a8a81e4333be77ab2a37579436
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
B and T cell receptor diversity can be studied by high-throughput immune receptor sequencing. Here, the authors develop a software tool, IGoR, that calculates the likelihoods of potential V(D)J recombination and somatic hypermutation scenarios from r
Externí odkaz:
https://doaj.org/article/0ed29de96e8f4e7995e61fd3999c3c6e
Publikováno v:
Physical Review X, Vol 10, Iss 3, p 031018 (2020)
Many living and complex systems exhibit second-order emergent dynamics. Limited experimental access to the configurational degrees of freedom results in data that appear to be generated by a non-Markovian process. This limitation poses a challenge in
Externí odkaz:
https://doaj.org/article/2008d8db63ef41e5a1e2786b4d52cf2c
Publikováno v:
Vaccines, Vol 8, Iss 1, p 13 (2020)
The human antibody repertoire is generated by the recombination of different gene segments as well as by processes of somatic mutation. Together these mechanisms result in a tremendous diversity of antibodies that are able to combat various pathogens
Externí odkaz:
https://doaj.org/article/6fb6b4d189cf49c28a6756138c3614fc
Autor:
Susana Magadan, Luc Jouneau, Maximilian Puelma Touzel, Simon Marillet, Wahiba Chara, Adrien Six, Edwige Quillet, Thierry Mora, Aleksandra M. Walczak, Frédéric Cazals, Oriol Sunyer, Simon Fillatreau, Pierre Boudinot
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Vaccination induces “public” antibody clonotypes common to all individuals of a species, that may mediate universal protection against pathogens. Only few studies tried to trace back the origin of these public B-cell clones. Here we used Illumina
Externí odkaz:
https://doaj.org/article/ecf3be8b01c347e9bd318d5dedbe6dc7
Autor:
Adar Toledano, Yuval Elhanati, Jennifer I. C. Benichou, Aleksandra M. Walczak, Thierry Mora, Yoram Louzoun
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The naïve immunoglobulin (IG) repertoire in the blood differs from the direct output of the rearrangement process. These differences stem from selection that affects the germline gene usage and the junctional nucleotides. A major complication obscur
Externí odkaz:
https://doaj.org/article/b00f7c8ed82444c0bc293fcbb1ebe347
Publikováno v:
Pathogens, Vol 8, Iss 3, p 115 (2019)
Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the eff
Externí odkaz:
https://doaj.org/article/c27978befb3d444ba36bfa61596df20e