Výsledky vyhledávání - "Aleksandra M. Glodek"

Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1

Autor: Lloyd B. Klickstein, Aleksandra M. Glodek, Gregory Weaver, Anne Nicholson-Weller, Ionita Ghiran

Publikováno v: Blood. 112:3465-3473

The primary identified function of complement receptor 1 (CR1/CD35) on primate erythrocytes is to bind complement-tagged inflammatory particles including microbes and immune complexes. When erythrocytes circulate through liver and spleen, sinusoidal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e329197a4ba48d70a5eff92d3423362
https://doi.org/10.1182/blood-2008-04-151845

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CXC Chemokine Ligand 12-Induced Focal Adhesion Kinase Activation and Segregation into Membrane Domains Is Modulated by Regulator of G Protein Signaling 1 in Pro-B Cells

Autor: Yi Le, Aleksandra M. Glodek, Leslie E. Silberstein, Marek Honczarenko, Daniel K. Ho

Publikováno v: The Journal of Immunology. 174:2582-2590

CXCL12-induced chemotaxis and adhesion to VCAM-1 decrease as B cells differentiate in the bone marrow. However, the mechanisms that regulate CXCL12/CXCR4-mediated signaling are poorly understood. We report that after CXCL12 stimulation of progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d52fc2735f52aed4d947df398da77f
https://doi.org/10.4049/jimmunol.174.5.2582

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Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells

Autor: Aleksandra M. Glodek, Leslie E. Silberstein, Tanja Nicole Hartmann, Nobutaka Fujii, Thomas J. Kipps, Anette Schmitt-Gräff, Jan Andreas Burger, Meike Burger

Publikováno v: Oncogene. 22:8093-8101

Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275095d0fa7d8c6b78940c049faba2bf
https://doi.org/10.1038/sj.onc.1207097

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Ligation of complement receptor 1 increases erythrocyte membrane deformability

Autor: Anne Nicholson-Weller, Sergey S. Shevkoplyas, Rossen Mirchev, Joseph A. Khoory, Ionita Ghiran, Aleksandra M. Glodek, David E. Golan, Jennie M. Burns

Microbes as well as immune complexes and other continuously generated inflammatory particles are efficiently removed from the human circulation by red blood cells (RBCs) through a process called immune-adherence clearance. During this process, RBCs u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a08aa4d35831b07ff65cdd270c1d9b
https://europepmc.org/articles/PMC3031392/

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Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells

Autor: Yi Le, Judy Lieberman, Richard C. Mulligan, Gustavo Mostoslavsky, Aleksandra M. Glodek, Derek M. Dykxhoorn, Hilary E. Beggs, Marek Honczarenko, S-Y Park, Leslie E. Silberstein

Publikováno v: Leukemia. 21(8)

Hematopoietic stem/progenitor cells (HSC/P) reside in the bone marrow in distinct anatomic locations (niches) to receive growth, survival and differentiation signals. HSC/P localization and migration between niches depend on cell-cell and cell-matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540fc1857fc2ec9767ce4a7af86bf3cd
https://pubmed.ncbi.nlm.nih.gov/17568820

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Developmental stage-specific shift in responsiveness to chemokines during human B-cell development

Autor: Marcin Swierkowski, Leslie E. Silberstein, Marek Honczarenko, Aleksandra M. Glodek, Il-Kang Na

Publikováno v: Experimental hematology. 34(8)

Objectives To better understand the role of chemokines during human B-cell development in bone marrow. Methods Differentiation stage–specific B cells (pro-B, pre-B, immature, and mature) were analyzed for chemokine receptor expression and for migra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aa0e114fc1b983ce8207ee59138d11
https://pubmed.ncbi.nlm.nih.gov/16863916

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Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors

Autor: Yi Le, Marcin Swierkowski, Leslie E. Silberstein, Ionita Ghiran, Aleksandra M. Glodek, Marek Honczarenko

Publikováno v: Stem cells (Dayton, Ohio). 24(4)

Stromal cells isolated from bone marrow (BMSCs), often referred to as mesenchymal stem cells, are currently under investigation for a variety of therapeutic applications. However, limited data are available regarding receptors that can influence thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8186400ed1b7c84683fe661561fee31
https://pubmed.ncbi.nlm.nih.gov/16253981

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