Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Aleksandra M Walczak"'
Publikováno v:
eLife, Vol 13 (2024)
B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and somatic hypermutations. B-cell clonal families stem from the same V(D)J r
Externí odkaz:
https://doaj.org/article/e9640bc963ad4785be72a3e83d8576f9
Autor:
Barbara Bravi, Andrea Di Gioacchino, Jorge Fernandez-de-Cossio-Diaz, Aleksandra M Walczak, Thierry Mora, Simona Cocco, Rémi Monasson
Publikováno v:
eLife, Vol 12 (2023)
Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key properties underlying effective immune responses. Here we propose diffRBM, an approach based on transfer learning and Restricted Boltzmann Machines, to buil
Externí odkaz:
https://doaj.org/article/3aa7f87a1a4c4800a52f77d2f9c090cd
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010652 (2023)
Adaptive immunity's success relies on the extraordinary diversity of protein receptors on B and T cell membranes. Despite this diversity, the existence of public receptors shared by many individuals gives hope for developing population-wide vaccines
Externí odkaz:
https://doaj.org/article/bb2bc1f4fbc1448596f53841e4f6c619
Autor:
Xiaowen Chen, Faustine Ginoux, Martin Carbo-Tano, Thierry Mora, Aleksandra M Walczak, Claire Wyart
Publikováno v:
eLife, Vol 12 (2023)
One challenge in neuroscience is to understand how information flows between neurons in vivo to trigger specific behaviors. Granger causality (GC) has been proposed as a simple and effective measure for identifying dynamical interactions. At single-c
Externí odkaz:
https://doaj.org/article/eab8bf660e954772b7a15de6628396e5
Autor:
Francesco Camaglia, Arie Ryvkin, Erez Greenstein, Shlomit Reich-Zeliger, Benny Chain, Thierry Mora, Aleksandra M Walczak, Nir Friedman
Publikováno v:
eLife, Vol 12 (2023)
One of the feats of adaptive immunity is its ability to recognize foreign pathogens while sparing the self. During maturation in the thymus, T cells are selected through the binding properties of their antigen-specific T-cell receptor (TCR), through
Externí odkaz:
https://doaj.org/article/a2c93bda44ab45a9909f76857e4c2dc8
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010167 (2022)
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions o
Externí odkaz:
https://doaj.org/article/973030ca05f644d6a2d14d1d90e625c6
Autor:
Gonçalo Fernandes, Huy Tran, Maxime Andrieu, Youssoupha Diaw, Carmina Perez Romero, Cécile Fradin, Mathieu Coppey, Aleksandra M Walczak, Nathalie Dostatni
Publikováno v:
eLife, Vol 11 (2022)
For over 40 years, the Bicoid-hunchback (Bcd-hb) system in the fruit fly embryo has been used as a model to study how positional information in morphogen concentration gradients is robustly translated into step-like responses. A body of quantitative
Externí odkaz:
https://doaj.org/article/74b36707781e417ebf4a45ed6e5f5aa2
Publikováno v:
eLife, Vol 10 (2021)
The spatial organization of complex biochemical reactions is essential for the regulation of cellular processes. Membrane-less structures called foci containing high concentrations of specific proteins have been reported in a variety of contexts, but
Externí odkaz:
https://doaj.org/article/3fbcc40c70814c5094e063f34bb47674
Autor:
Barbara Bravi, Vinod P Balachandran, Benjamin D Greenbaum, Aleksandra M Walczak, Thierry Mora, Rémi Monasson, Simona Cocco
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009297 (2021)
With the increasing ability to use high-throughput next-generation sequencing to quantify the diversity of the human T cell receptor (TCR) repertoire, the ability to use TCR sequences to infer antigen-specificity could greatly aid potential diagnosti
Externí odkaz:
https://doaj.org/article/1b09e79bd3cc42a9a6d184af909b44d9
Autor:
Angela M Phillips, Katherine R Lawrence, Alief Moulana, Thomas Dupic, Jeffrey Chang, Milo S Johnson, Ivana Cvijovic, Thierry Mora, Aleksandra M Walczak, Michael M Desai
Publikováno v:
eLife, Vol 10 (2021)
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated. Structural and biochemical characterization of these bnAbs has provided molecular insight into how
Externí odkaz:
https://doaj.org/article/a52f4aaca9534b4cbaabd27a7b983cb0