Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aleksandra Lezaja"'
Autor:
Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell
Externí odkaz:
https://doaj.org/article/9a9e8cf86c824c509c51e25d4696fdaf
Autor:
Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof, Matthias Altmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to st
Externí odkaz:
https://doaj.org/article/69cfbc985a4f4f299345fc43300b4c9c
Autor:
Lukas Hafner, Aleksandra Lezaja, Xu Zhang, Laure Lemmens, Maksym Shyian, Benjamin Albert, Cindy Follonier, Jose Manuel Nunes, Massimo Lopes, David Shore, Stefano Mattarocci
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 983-992 (2018)
Summary: The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily conserved role in control of DNA replication timing by promoting PP1-dependent dephosphorylation of replication initiation factors. However, ScRif1 binding ou
Externí odkaz:
https://doaj.org/article/d5456f381b5b400bb0c531535c844a05
Autor:
Maksym Shyian, Stefano Mattarocci, Benjamin Albert, Lukas Hafner, Aleksandra Lezaja, Michael Costanzo, Charlie Boone, David Shore
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006414 (2016)
The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphat
Externí odkaz:
https://doaj.org/article/2a01a20ba7084ee9a585b2727511a8ba
Autor:
Bernardo Reina-San-Martin, Karen Meaburn, Duygu Yilmaz, Audrey Furst, Evi Soutoglou, Yanlin Wen, Aleksandra Lezaja, Matthias Altmeyer
Publikováno v:
Nature
Nature, 2021, 600, pp.748-753. ⟨10.1038/s41586-021-04200-z⟩
Nature, 2021, 600, pp.748-753. ⟨10.1038/s41586-021-04200-z⟩
Centromeric integrity is key for proper chromosome segregation during cell division1. Centromeres have unique chromatin features that are essential for centromere maintenance2. Although they are intrinsically fragile and represent hotspots for chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f58905d7aa6267213fb94bbb657ed77
https://hal.science/hal-03714790
https://hal.science/hal-03714790
Autor:
Aleksandra Lezaja, David Shore, Benjamin Albert, Stefano Mattarocci, Lukas Hafner, Maria Jessica Bruzzone, Slawomir Kubik
Mittal et al. (2021; first brought to our attention in May 2019) have raised concerns regarding the Chromatin Endogenous Cleavage-sequencing (ChEC-seq) technique (Zentner et al., 2015) that may create a false impression that this method has fundament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c862bc0855f980d9b6d8f1792160a7
https://doi.org/10.1101/2021.02.18.431798
https://doi.org/10.1101/2021.02.18.431798
Autor:
Aleksandra Lezaja, Matthias Altmeyer
Publikováno v:
Current Opinion in Cell Biology
Subversion of genome integrity fuels cellular adaptation and is a prerequisite for organismal evolution, yet genomic lesions are also the harmful driving force of cancer and other age-related human diseases. Genome integrity maintenance is inherently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4084a0fedb5006076953745111753275
Autor:
Aleksandra Lezaja, Ralph Imhof, Edison S. M. Carvalho, Yanlin Wen, Andreas Panagopoulos, Matthias Altmeyer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The paradigm that checkpoints halt cell cycle progression for genome repair has been challenged by the recent discovery of heritable DNA lesions escaping checkpoint control. How such inherited lesions affect genome function and integrity is not well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0863bff3e90e14720a685b4e64a1df
https://pubmed.ncbi.nlm.nih.gov/34158486
https://pubmed.ncbi.nlm.nih.gov/34158486
Autor:
Matthias Altmeyer, Aleksandra Lezaja
Publikováno v:
BIOspektrum. 24:269-272
Automated high-throughput microscopy has been instrumental for drug discovery and large-scale gene perturbation screens. Advancements in image resolution, microscope speed, and detection sensitivity have greatly aided high-content imaging approaches.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229d69e8f5c082567364020a8a854b45
https://doi.org/10.1007/s12268-018-0918-5
https://doi.org/10.1007/s12268-018-0918-5
Autor:
Laure Lemmens, Cindy Follonier, Lukas Hafner, Stefano Mattarocci, Xu Zhang, Jose Manuel Nunes, David Shore, Maksym Shyian, Benjamin Albert, Aleksandra Lezaja, Massimo Lopes
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 983-992 (2018)
Summary: The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily conserved role in control of DNA replication timing by promoting PP1-dependent dephosphorylation of replication initiation factors. However, ScRif1 binding ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d762de92cc03b62b5cadd57bbc5c25dd
https://doi.org/10.1016/j.celrep.2018.03.113
https://doi.org/10.1016/j.celrep.2018.03.113