A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk

Autor: Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami‐Hodjegan, Brian J. Schmidt, Lu Gaohua, Aleksandra Galetin

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 11, Pp 1856-1869 (2024)

Abstract Breastfeeding is the most complete nutritional method of feeding infants, but several impediments affect the decision to breastfeed, including questions of drug safety for medications needed during lactation. Despite recent FDA guidance, few

Externí odkaz: https://doaj.org/article/7b1e0da885c44b1aa5e125279d3a9ef4

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

Autor: Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 467-477 (2021)

Abstract Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs). Pyridoxic acid (PDA) and homovanillic acid (HVA) were indicated as potenti

Externí odkaz: https://doaj.org/article/5bf2ee103c154af4818724a4d2d8a5c3

PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter‐Individual Variability

Autor: Hiroyuki Takita, Shelby Barnett, Yueping Zhang, Karelle Ménochet, Hong Shen, Kayode Ogungbenro, Aleksandra Galetin

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 137-147 (2021)

Coproporphyrin I (CPI) is an endogenous biomarker of OATP1B activity and associated drug‐drug interactions. In this study, a minimal physiologically‐based pharmacokinetic model was developed to investigate the impact of OATP1B1 genotype (c.521T>C

Externí odkaz: https://doaj.org/article/bcb3eb0e26ae41549ab32adc6ba6bc94

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

Autor: Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 5, Pp 282-293 (2020)

Creatinine is widely used as a biomarker of glomerular filtration, and, hence, renal function. However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a lesser degree. Inhibition of these transporters causes trans

Externí odkaz: https://doaj.org/article/a73aaba8c1184e2e9e73af246614abb7

Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies

Autor: Luca Docci, Nicolò Milani, Thomas Ramp, Andrea A. Romeo, Patricio Godoy, Daniela Ortiz Franyuti, Stephan Krähenbühl, Michael Gertz, Aleksandra Galetin, Neil Parrott, Stephen Fowler

Publikováno v: Docci, L, Milani, N, Ramp, T, Romeo, A A, Godoy, P, Franyuti, D O, Krähenbühl, S, Gertz, M, Galetin, A, Parrott, N & Fowler, S 2022, ' Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies ', Lab on a Chip, vol. 22, no. 6, pp. 1187-1205 . https://doi.org/10.1039/D1LC01161H

Microphysiological systems (MPS) are complex and more physiologically realistic cellular in vitro tools that aim to provide more relevant human in vitro data for quantitative prediction of clinical pharmacokinetics while also reducing the need for an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113dfbdeee1c6215e9b32e03e731469e
https://doi.org/10.1039/d1lc01161h