Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Aleksandra Filipowicz"'
1
Akademický článek
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro
Autor: Łukasz Uram, Maria Misiorek, Monika Pichla, Aleksandra Filipowicz-Rachwał, Joanna Markowicz, Stanisław Wołowiec, Elżbieta Wałajtys-Rode
Publikováno v: Molecules, Vol 24, Iss 20, p 3801 (2019)
Glioblastoma multiforme (GBM) is the most malignant type of central nervous system tumor that is resistant to all currently used forms of therapy. Thus, more effective GBM treatment strategies are being investigated, including combined therapies with
Externí odkaz: https://doaj.org/article/dc164ca2f168448a8f3a97f13d82e3ea
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2
Akademický článek
Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells
Autor: Łukasz Uram, Aleksandra Filipowicz-Rachwał, Maria Misiorek, Aleksandra Winiarz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
Publikováno v: Biomolecules, Vol 9, Iss 9, p 437 (2019)
Squamous cell carcinoma (SCC) remains a main cause of mortality in patients with neck and head cancers, with poor prognosis and increased prevalence despite of available therapies. Recent studies have identified a role of cyclooxygenases, particularl
Externí odkaz: https://doaj.org/article/c6caf670a1134d48a2394e9f2afb1150
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3
Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent
Autor: Maria Misiorek, Joanna Markowicz, Elżbieta Wałajtys-Rode, Łukasz Uram, Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 152
Glioblastoma multiforme (GBM) is a one of the most widely diagnosed and difficult to treat type of central nervous system tumors. Resection combined with radiotherapy and temozolomide (TMZ) chemotherapy prolongs patients' survival only for 12 - 15 mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3334281384abfbd4700ade1b74a4371e
https://pubmed.ncbi.nlm.nih.gov/32615261
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4
The effect of G3 PAMAM dendrimer conjugated with B-group vitamins on cell morphology, motility and ATP level in normal and cancer cells
Autor: Aleksandra Filipowicz, Maria Misiorek, Elżbieta Wałajtys-Rode, Stanisław Wołowiec, Łukasz Uram, Magdalena Szuster
Publikováno v: European Journal of Pharmaceutical Sciences. 102:275-283
In a search for the safe vitamin carrier the PAMAM G3 dendrimer covalently substituted with 9 and 10 molecules of vitamin B7 (biotin) and B6 (pyridoxal), respectively (BC-PAMAM) was investigated. Dendrimer substitution with B-group vitamins significa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde1cdf9e88278e68a2dc3b136bfa1e9
https://doi.org/10.1016/j.ejps.2017.03.022
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5
Cellular uptake of glucoheptoamidated poly(amidoamine) PAMAM G3 dendrimer with amide-conjugated biotin, a potential carrier of anticancer drugs
Autor: Aleksandra Filipowicz, Łukasz Uram, Elżbieta Wałajtys-Rode, Stanisław Wołowiec, Magdalena Zaręba, Magdalena Szuster
Publikováno v: Bioorganic & Medicinal Chemistry. 25:706-713
In search for soluble derivatives of PAMAM dendrimers as potential carriers for hydrophobic drugs, the conjugates of PAMAM G3 with biotin, further converted into glycodendrimer with d-glucoheptono-1,4-lactone, were prepared. Polyamidoamine dendrimer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5b397df462726f74b65c8c7101d77d
https://doi.org/10.1016/j.bmc.2016.11.047
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6
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro
Autor: Monika Pichla, Elżbieta Wałajtys-Rode, Maria Misiorek, Joanna Markowicz, Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec, Łukasz Uram
Publikováno v: Molecules
Volume 24
Issue 20
Molecules, Vol 24, Iss 20, p 3801 (2019)
Glioblastoma multiforme (GBM) is the most malignant type of central nervous system tumor that is resistant to all currently used forms of therapy. Thus, more effective GBM treatment strategies are being investigated, including combined therapies with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aff736f502498a2ca489d1b1c2fffb7
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7
Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells
Autor: Maria Misiorek, Łukasz Uram, Aleksandra Winiarz, Aleksandra Filipowicz-Rachwał, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
Publikováno v: Biomolecules
Biomolecules, Vol 9, Iss 9, p 437 (2019)
Volume 9
Issue 9
Squamous cell carcinoma (SCC) remains a main cause of mortality in patients with neck and head cancers, with poor prognosis and increased prevalence despite of available therapies. Recent studies have identified a role of cyclooxygenases, particularl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4600ff11e2418cdbce11dfd929761e
http://europepmc.org/articles/PMC6770390
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8
Evaluation of the localization and biological effects of PAMAM G3 dendrimer-biotin/pyridoxal conjugate as HaCaT keratinocyte targeted nanocarrier
Autor: Aleksandra Filipowicz-Rachwał, Stanisław Wołowiec, Magdalena Szuster, Elżbieta Wałajtys-Rode, Łukasz Uram
Publikováno v: Acta Biochimica Polonica.
Recognition of the molecular mechanisms of keratinocyte participation in normal skin homeostasis and in pathogenesis may lead to creation of more effective tools for topical application of cosmetics, cosmeceutics and drugs to a particular location wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f9aaef46fbc53a304315cde453b557
https://doi.org/10.18388/abp.2018_2767
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9
Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines
Autor: Aleksandra Filipowicz, Stanisław Wołowiec, Elżbieta Wałajtys-Rode, Łukasz Uram, Joanna Markowicz, Maria Misiorek, Natalia Pieńkowska
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 124
Tumors still remain one of the main causes of mortality due to the lack of effective anti-cancer therapy. Recently it has been shown, that overexpression of inducible cyclooxygenase-2 (COX-2) and decrease of peroxisome proliferator-activated receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df11a679047e0e6dfb31e0877f08c8e
https://pubmed.ncbi.nlm.nih.gov/30118847
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10
Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate
Autor: Aleksandra Filipowicz, Stanisław Wołowiec
Publikováno v: International Journal of Nanomedicine, Vol 2012, Iss default, Pp 4819-4828 (2012)
International Journal of Nanomedicine
A Filipowicz, S WołowiecDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, Rzeszów, PolandBackground: Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as carriers for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339af25f62db0feff691066c4cf96856
http://www.dovepress.com/bioconjugates-of-pamam-dendrimers-with-trans-retinal-pyridoxal-and-pyr-a10915
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