Preliminary results of a phase II study: PD-1 blockade in mismatch repair–deficient, recurrent or persistent endometrial cancer

Autor: Jennifer N. Uram, Edward J. Tanner, Tim F. Greten, George A. Fisher, Dung T. Le, D. K. Armstrong, Amanda N. Fader, Luis A. Diaz, Aleksandra Eyring, Hao Wang

Publikováno v: Gynecologic Oncology. 141:206-207

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6131243c00c9a3fe388aa249bbd9fb
https://doi.org/10.1016/j.ygyno.2016.04.532

Programmed death-1 blockade in mismatch repair deficient cancer independent of tumor histology

Autor: Tim F. Greten, Bert Vogelstein, Bjarne Bartlett, Tianna Dauses, Jennifer N. Uram, Daniel A. Laheru, James J. Lee, Christian F. Meyer, Nilofer S. Azad, Todd S. Crocenzi, George A. Fisher, Hao Wang, Deborah K. Armstrong, Amanda N. Fader, Luis A. Diaz, Dung T. Le, Minori Koshiji, Richard M. Goldberg, Aleksandra Eyring, Holly Kemberling

Publikováno v: Journal of Clinical Oncology. 34:3003-3003

3003Background: Mismatch repair deficiency (MRD) is feature of many cancers at a frequency of approximately 1 in 30 patients independent of tumor histology. Tumors with MRD are deficient in the repair of specific DNA replication errors and as a resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5badc598bcfd6a692e30954a1113dfc4
https://doi.org/10.1200/jco.2016.34.15_suppl.3003

PD-1 blockade in tumors with mismatch repair deficiency

Autor: Steve M Duffy, Hao Wang, Holly Kemberling, Bjarne Bartlett, Nilofer S. Azad, Dung T. Le, Robert A. Anders, George A. Fisher, Andrew D. Skora, Ross C. Donehower, Brandon Luber, Daniel A. Laheru, Bert Vogelstein, Todd S. Crocenzi, Jennifer N. Uram, Luis A. Diaz, Aleksandra Eyring, Minori Koshiji, James R. Eshleman, James J. Lee

Publikováno v: Journal of Clinical Oncology. 33:LBA100-LBA100

LBA100 Background: Somatic mutations have the potential to be recognized as “non-self” immunogenic antigens. Tumors with genetic defects in mismatch repair (MMR) harbor many more mutations than tumors of the same type without such repair defects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d0677a11ee5fceb6aea6e0bb072007
https://doi.org/10.1200/jco.2015.33.15_suppl.lba100

Comparison of the Idylla™ MSI assay with the Promega™ MSI Analysis System and immunohistochemistry on formalin-fixed paraffin-embedded tissue of endometrial carcinoma: results from an international, multicenter study.

Autor: Gatius S; Hospital Universitari Arnau de Vilanova, Universitat de Lleida, IRBLleida, CIBERONC, Av Rovira Roure, 80, 25198, Lleida, Spain. sgatius.lleida.ics@gencat.cat., Velasco A; Hospital Universitari Arnau de Vilanova, Universitat de Lleida, IRBLleida, CIBERONC, Av Rovira Roure, 80, 25198, Lleida, Spain., Varela M; Hospital Universitari de Bellvitge, Universitat de Barcelona, IDIBELL, CIBERONC, Barcelona, Spain., Cuatrecasas M; Pathology Department, CDB, Hospital Clinic, Barcelona, Universitat de Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain., Jares P; Pathology Department, CDB, Hospital Clinic, Barcelona, Universitat de Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain., Setaffy L; Department of Pathology, General Hospital Graz II, Styrian Hospital Corporation and Medical University of Graz, Graz, Austria., Bonhomme B; Département de Biopathologie, Institut Bergonié, Bordeaux, France., Santon A; Hospital Ramon Y Cajal, IRYCIS, CIBERONC, Madrid, Spain., Lindemann K; Department of Gynecologic Oncology, Division of Cancer Medicine, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0316, Oslo, Norway., Croce S; Department of Pathology, General Hospital Graz II, Styrian Hospital Corporation and Medical University of Graz, Graz, Austria., Davidson B; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0316, Oslo, Norway.; Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, 0310, Oslo, Norway., Lax S; Department of Pathology, General Hospital Graz II, Styrian Hospital Corporation and Medical University of Graz, Graz, Austria.; School of Medicine, Johannes Kepler University, Linz, Austria., Palacios J; Hospital Ramon Y Cajal, IRYCIS, CIBERONC, Madrid, Spain.; Faculty of Medicine, University of Alcalá, Madrid, Spain., Matias-Guiu X; Hospital Universitari Arnau de Vilanova, Universitat de Lleida, IRBLleida, CIBERONC, Av Rovira Roure, 80, 25198, Lleida, Spain.; Hospital Universitari de Bellvitge, Universitat de Barcelona, IDIBELL, CIBERONC, Barcelona, Spain.

Publikováno v: Virchows Archiv : an international journal of pathology [Virchows Arch] 2022 May; Vol. 480 (5), pp. 1031-1039. Date of Electronic Publication: 2022 Feb 05.