Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aleksandra Bielen"'
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Pediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640aae47942f24340443cc8cc3e198f2
https://doi.org/10.1158/1535-7163.c.6535482
https://doi.org/10.1158/1535-7163.c.6535482
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 3 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ea1a0d2375245f2f675778fbd807ca
https://doi.org/10.1158/1535-7163.22497045
https://doi.org/10.1158/1535-7163.22497045
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 1 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e2e83c50e82bfdffe58fedf9bc1cf
https://doi.org/10.1158/1535-7163.22497051
https://doi.org/10.1158/1535-7163.22497051
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 2 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36acbf2d62a640c492d6925e4c982075
https://doi.org/10.1158/1535-7163.22497048
https://doi.org/10.1158/1535-7163.22497048
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 4 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f3d979d3f73f11e6aadf88a7c1e75a
https://doi.org/10.1158/1535-7163.22497042.v1
https://doi.org/10.1158/1535-7163.22497042.v1
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure Legends 1-4 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e605df45e48e879d336038740a6233d
https://doi.org/10.1158/1535-7163.22497039
https://doi.org/10.1158/1535-7163.22497039
Autor:
Gary Box, Francesco Hofmann, Sharon Gowan, Florence I. Raynaud, Sergey V. Popov, Sébastien Jeay, Vanessa Martins, Chris Jones, Alexis De Haven Brandon, Aleksandra Bielen, Alexa Jury, Melanie Valenti, Darren Hargrave, Lara Perryman, Suzanne A. Eccles
Publikováno v:
Molecular Cancer Therapeutics. 10:1407-1418
Pediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3cd665b8390bc0880f0feb9b6d7fde
https://doi.org/10.1158/1535-7163.mct-11-0205
https://doi.org/10.1158/1535-7163.mct-11-0205
Autor:
Vincent Romanet, Alexa Jury, Simon P. Robinson, Aleksandra Bielen, Lynn Bjerke, Yann Jamin, Florence I. Raynaud, Sébastien Jeay, Gary Box, Francesco Hofmann, Chris Jones, Lara Perryman, Melanie Valenti, Alexis De Haven Brandon, Sergey V. Popov, Suzanne A. Eccles, Vanessa Martins
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(20)
We have previously demonstrated an increased DNA copy number and expression of IGF1R to be associated with poor outcome in Wilms tumors. We have now tested whether inhibiting this receptor may be a useful therapeutic strategy by using a panel of Wilm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204e0e0f4505018676b93952b36d6d6b
https://pubmed.ncbi.nlm.nih.gov/22529373
https://pubmed.ncbi.nlm.nih.gov/22529373
Autor:
Chris Jones, Yuen-Li Chung, John R. Griffiths, Anne-Christine Wong Te Fong, Aleksandra Bielen, Gabriela Andrejeva, Martin O. Leach
Publikováno v:
Cancer Research. 74:2451-2451
Introduction: Previously we showed that Picropodophyllin (PPP) - an inhibitor of Insulin-Like Growth Factor-1 Receptor (IGF-1R) promotes the Warburg effect and this effect is associated with the downregulation of p53 after 24h of PPP-treatment. Activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404ac702c90b2927579c675686fd8e02
https://doi.org/10.1158/1538-7445.am2014-2451
https://doi.org/10.1158/1538-7445.am2014-2451
Autor:
Martin O. Leach, Harry G. Parkes, Yuen-Li Chung, Chris Jones, Aleksandra Bielen, John R. Griffiths, Ian Judson, Anne-Christine Wong Te Fong, Thomas R. Eykyn
Publikováno v:
Clinical Cancer Research. 18:B61-B61
Introduction: Picropodophyllin (PPP) is of interest as an anti-cancer agent, as it has been shown to induce growth inhibition and apoptosis in a variety of human cancer cells and xenografts. Recently, PPP was found to have dramatic antitumor effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ee9c8faf8b9153c1926eb2298b74ca
https://doi.org/10.1158/1078-0432.mechres-b61
https://doi.org/10.1158/1078-0432.mechres-b61