Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Aleksandra Aizenshtadt"'
Autor:
Ingrid Wilhelmsen, Thomas Combriat, Andrea Dalmao-Fernandez, Justyna Stokowiec, Chencheng Wang, Petter Angell Olsen, Jonas Aakre Wik, Yuliia Boichuk, Aleksandra Aizenshtadt, Stefan Krauss
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Hepatic stellate cells (HSC) have numerous critical roles in liver function and homeostasis, while they are also known for their importance during liver injury and fibrosis. There is therefore a need for relevant in vitro human HS
Externí odkaz:
https://doaj.org/article/dbbe1592310a4cfd8a57b7b979f5324e
Autor:
Chencheng Wang, Shadab Abadpour, Aleksandra Aizenshtadt, Andrea Dalmao-Fernandez, Merete Høyem, Ingrid Wilhelmsen, Justyna Stokowiec, Petter Angell Olsen, Stefan Krauss, Simona Chera, Luiza Ghila, Helge Ræder, Hanne Scholz
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Stem cell-derived islets (SC-islets) are not only an unlimited source for cell-based therapy of type 1 diabetes but have also emerged as an attractive material for modeling diabetes and conducting screening for treatment options. Prior to SC-islets b
Externí odkaz:
https://doaj.org/article/4afe0562c8be4495b25a69fa136af8a3
Autor:
Chencheng Wang, Shadab Abadpour, Petter Angell Olsen, Daxin Wang, Justyna Stokowiec, Simona Chera, Luiza Ghila, Helge Ræder, Stefan Krauss, Aleksandra Aizenshtadt, Hanne Scholz
Publikováno v:
Transplant International, Vol 37 (2024)
The generation of insulin-producing cells from human-induced pluripotent stem cells holds great potential for diabetes modeling and treatment. However, existing protocols typically involve incubating cells with un-physiologically high concentrations
Externí odkaz:
https://doaj.org/article/ae50da630f3d444cb4d7bc5686d0412e
Autor:
André B. Cunha, Christin Schuelke, Alireza Mesri, Simen K. Ruud, Aleksandra Aizenshtadt, Giorgio Ferrari, Arto Heiskanen, Afia Asif, Stephan S. Keller, Tania Ramos-Moreno, Håvard Kalvøy, Alberto Martínez-Serrano, Stefan Krauss, Jenny Emnéus, Marco Sampietro, Ørjan G. Martinsen
Publikováno v:
Sensors, Vol 24, Iss 2, p 575 (2024)
Implantable cell replacement therapies promise to completely restore the function of neural structures, possibly changing how we currently perceive the onset of neurodegenerative diseases. One of the major clinical hurdles for the routine implementat
Externí odkaz:
https://doaj.org/article/3f9a8c018ef54dbb862e7626f2c1d860
Autor:
Ingrid Wilhelmsen, Mikel Amirola Martinez, Justyna Stokowiec, Chencheng Wang, Aleksandra Aizenshtadt, Stefan Krauss
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Background: There is a significant need for predictive and stable in vitro human liver representations for disease modeling and drug testing. Hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) are important non-parenchymal c
Externí odkaz:
https://doaj.org/article/573a0c5143814e1db7707f01b32cc3bb
Autor:
Andrea Dalmao-Fernandez, Aleksandra Aizenshtadt, Hege G. Bakke, Stefan Krauss, Arild C. Rustan, G. Hege Thoresen, Eili Tranheim Kase
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Skeletal muscle is a major contributor to whole-body energy homeostasis and the utilization of fatty acids and glucose. At present, 2D cell models have been the most used cellular models to study skeletal muscle energy metabolism. Howev
Externí odkaz:
https://doaj.org/article/b4dd0506ab1d4dd487b3cdad5fa28ab5
Autor:
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Ståle Nygård, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102807- (2021)
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferativ
Externí odkaz:
https://doaj.org/article/27f687164a79487eab40d162285fd4c2
Publikováno v:
Biosensors, Vol 12, Iss 2, p 126 (2022)
Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studyin
Externí odkaz:
https://doaj.org/article/c1e9afb9fbde46b8b53a67cf18580257
Autor:
Mathias Busek, Steffen Nøvik, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Thomas Combriat, Stefan Grünzner, Stefan Krauss
Publikováno v:
Biosensors, Vol 11, Iss 5, p 162 (2021)
Polydimethylsiloxane (PDMS) has been used in microfluidic systems for years, as it can be easily structured and its flexibility makes it easy to integrate actuators including pneumatic pumps. In addition, the good optical properties of the material a
Externí odkaz:
https://doaj.org/article/75122455b1bb456faab8a5981c2dc61b
Autor:
Stian Kogler, Aleksandra Aizenshtadt, Sean Harrison, Frøydis Sved Skottvoll, Henriette Engen Berg, Shadab Abadpour, Hanne Scholz, Gareth Sullivan, Bernd Thiede, Elsa Lundanes, Inger Lise Bogen, Stefan Krauss, Hanne Røberg-Larsen, Steven Ray Wilson
Publikováno v:
Analytical Chemistry. 94:17677-17684
Organoids, i.e. laboratory-grown organ models developed from stem cells, are emerging tools for studying organ physiology, disease modeling and drug development. On-line analysis of organoids with mass spectrometry would provide analytical versatilit