Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Aleksandra Misicka"'
Publikováno v:
Folia Neuropathologica, Vol 58, Iss 3, Pp 237-244 (2020)
A neuropeptide, Substance P (SP), has mitogenic action in many types of cancer cells mediated via the neurokinin-1 receptor (NK1R). Small molecular NK1R antagonists have been frequently shown to possess anticancer activity both in vivo and in vitro,
Externí odkaz:
https://doaj.org/article/9f7955f988114505b9186be3206fb5c2
Autor:
Katarzyna Masłowska, Patrycja Redkiewicz, Paweł Krzysztof Halik, Ewa Witkowska, Dagmara Tymecka, Rafał Walczak, Jarosław Choiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 564 (2023)
Pathological angiogenesis, resulting from an imbalance between anti- and pro-angiogenic factors, plays a pivotal role in tumor growth, development and metastasis. The inhibition of the angiogenesis process by the VEGF/VEGFR-2/NRP-1 pathway raises int
Externí odkaz:
https://doaj.org/article/2cf05b834e86486bb3a6648f5558e7f9
Autor:
Jolanta Dyniewicz, Stefan Mordalski, Piotr F. J. Lipiński, Andrzej J. Bojarski, Piotr Kosson, Joanna Matalińska, Aleksandra Misicka
Publikováno v:
Pharmacological Reports. 75:465-473
Background G protein-coupled receptors (GPCRs) transduce external stimuli into the cell by G proteins via an allosteric mechanism. Agonist binding to the receptor stimulates GDP/GTP exchange within the heterotrimeric G protein complex, whereas recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d99e1280c0f243fb7220d618a72ccb
https://doi.org/10.1007/s43440-023-00457-5
https://doi.org/10.1007/s43440-023-00457-5
Autor:
Marcin Robert Naliwajski, Beata Wileńska, Aleksandra Misicka, Agnieszka Pietrosiuk, Katarzyna Sykłowska-Baranek
Publikováno v:
Cells, Vol 11, Iss 6, p 931 (2022)
To cope with environmental harmful conditions, plant cells developed adaptive strategy that involves production of a wide variety of complex secondary metabolites. The spectrum and quantity of biosynthesized compounds in specific plant species is det
Externí odkaz:
https://doaj.org/article/cbbf4053430f45ef84f9ed562b01c9d2
Autor:
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 607 (2022)
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation of aprepitant-bas
Externí odkaz:
https://doaj.org/article/07bfb308c5454d1f949bdbfa1fc3e68e
Autor:
Katarzyna Masłowska, Ewa Witkowska, Dagmara Tymecka, Paweł Krzysztof Halik, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 100 (2022)
Neuropilin-1 (NRP-1) is a surface receptor found on many types of cancer cells. The overexpression of NRP-1 and its interaction with vascular endothelial growth factor-165 (VEGF165) are associated with tumor growth and metastasis. Therefore, compound
Externí odkaz:
https://doaj.org/article/677ba72fd4974c24977a5c43d2f12ad6
Autor:
Anita Śliwińska, Ramona Figat, Anna Zgadzaj, Beata Wileńska, Aleksandra Misicka, Grzegorz Nałęcz-Jawecki, Agnieszka Pietrosiuk, Katarzyna Sykłowska-Baranek
Publikováno v:
Molecules, Vol 27, Iss 1, p 186 (2021)
Hairy root cultures are considered as a valuable source of bioactive phytoconstituents with expanding applicability for their production. In the present study, hairy root cultures of Polyscias filicifolia (Araliaceae), a traditional Southeast Asian m
Externí odkaz:
https://doaj.org/article/b6ff812164aa47d7b03d99369e6042b4
Publikováno v:
Molecules, Vol 26, Iss 19, p 5777 (2021)
Chondrocalcinosis is a metabolic disease caused by the presence of calcium pyrophosphate dihydrate crystals in the synovial fluid. The goal of our endeavor was to find out whether short peptides could be used as a dissolving factor for such crystals.
Externí odkaz:
https://doaj.org/article/5f4ca272fc394718acc1954e919fba45
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Zhijun Wu, Justin LaVigne, Gabriella Molnar, Dagmara Tymecka, Aleksandra Misicka, John M. Streicher, Victor J. Hruby, Frank Porreca
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 625 (2021)
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Externí odkaz:
https://doaj.org/article/5b6b2c3eba6f414bbf633d9023f2ac2b
Autor:
Patrycja Redkiewicz, Jolanta Dyniewicz, Ewa Witkowska, Aleksandra Misicka, Piotr F. J. Lipiński
Publikováno v:
Journal of Peptide Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4fa5c29411eea687d48cf6ddf478364
https://doi.org/10.1002/psc.3487
https://doi.org/10.1002/psc.3487