Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Aleksandra, Misicka"'
Publikováno v:
Folia Neuropathologica, Vol 58, Iss 3, Pp 237-244 (2020)
A neuropeptide, Substance P (SP), has mitogenic action in many types of cancer cells mediated via the neurokinin-1 receptor (NK1R). Small molecular NK1R antagonists have been frequently shown to possess anticancer activity both in vivo and in vitro,
Externí odkaz:
https://doaj.org/article/9f7955f988114505b9186be3206fb5c2
Autor:
Katarzyna Masłowska, Patrycja Redkiewicz, Paweł Krzysztof Halik, Ewa Witkowska, Dagmara Tymecka, Rafał Walczak, Jarosław Choiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 564 (2023)
Pathological angiogenesis, resulting from an imbalance between anti- and pro-angiogenic factors, plays a pivotal role in tumor growth, development and metastasis. The inhibition of the angiogenesis process by the VEGF/VEGFR-2/NRP-1 pathway raises int
Externí odkaz:
https://doaj.org/article/2cf05b834e86486bb3a6648f5558e7f9
Autor:
Marcin Robert Naliwajski, Beata Wileńska, Aleksandra Misicka, Agnieszka Pietrosiuk, Katarzyna Sykłowska-Baranek
Publikováno v:
Cells, Vol 11, Iss 6, p 931 (2022)
To cope with environmental harmful conditions, plant cells developed adaptive strategy that involves production of a wide variety of complex secondary metabolites. The spectrum and quantity of biosynthesized compounds in specific plant species is det
Externí odkaz:
https://doaj.org/article/cbbf4053430f45ef84f9ed562b01c9d2
Autor:
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 607 (2022)
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation of aprepitant-bas
Externí odkaz:
https://doaj.org/article/07bfb308c5454d1f949bdbfa1fc3e68e
Autor:
Jolanta Dyniewicz, Stefan Mordalski, Piotr F. J. Lipiński, Andrzej J. Bojarski, Piotr Kosson, Joanna Matalińska, Aleksandra Misicka
Publikováno v:
Pharmacological Reports. 75:465-473
Background G protein-coupled receptors (GPCRs) transduce external stimuli into the cell by G proteins via an allosteric mechanism. Agonist binding to the receptor stimulates GDP/GTP exchange within the heterotrimeric G protein complex, whereas recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d99e1280c0f243fb7220d618a72ccb
https://doi.org/10.1007/s43440-023-00457-5
https://doi.org/10.1007/s43440-023-00457-5
Autor:
Ewa Witkowska, Magda Godlewska, Jowita Osiejuk, Sandra Gątarz, Beata Wileńska, Katarzyna Kosińska, Joanna Starnowska-Sokół, Anna Piotrowska, Piotr F. J. Lipiński, Joanna Matalińska, Jolanta Dyniewicz, Paweł K. Halik, Ewa Gniazdowska, Barbara Przewlocka, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 674 (2022)
Based on the mechanism of neuropathic pain induction, a new type of bifunctional hybrid peptidomimetics was obtained for potential use in this type of pain. Hybrids consist of two types of pharmacophores that are connected by different types of linke
Externí odkaz:
https://doaj.org/article/5ac1bbccccea45039db1a0643d59e8af
Autor:
Joanna Matalińska, Katarzyna Kosińska, Paweł K. Halik, Przemysław Koźmiński, Piotr F. J. Lipiński, Ewa Gniazdowska, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1214 (2022)
Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far, the radiopharmaceuticals used in this approach have been based on the endogenous agonist of N
Externí odkaz:
https://doaj.org/article/ffe5387d92fe4ac696320f656da8fa88
Autor:
Katarzyna Masłowska, Ewa Witkowska, Dagmara Tymecka, Paweł Krzysztof Halik, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 100 (2022)
Neuropilin-1 (NRP-1) is a surface receptor found on many types of cancer cells. The overexpression of NRP-1 and its interaction with vascular endothelial growth factor-165 (VEGF165) are associated with tumor growth and metastasis. Therefore, compound
Externí odkaz:
https://doaj.org/article/677ba72fd4974c24977a5c43d2f12ad6
Autor:
Anita Śliwińska, Ramona Figat, Anna Zgadzaj, Beata Wileńska, Aleksandra Misicka, Grzegorz Nałęcz-Jawecki, Agnieszka Pietrosiuk, Katarzyna Sykłowska-Baranek
Publikováno v:
Molecules, Vol 27, Iss 1, p 186 (2021)
Hairy root cultures are considered as a valuable source of bioactive phytoconstituents with expanding applicability for their production. In the present study, hairy root cultures of Polyscias filicifolia (Araliaceae), a traditional Southeast Asian m
Externí odkaz:
https://doaj.org/article/b6ff812164aa47d7b03d99369e6042b4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11347 (2021)
Biphalin, one of the opioid agonists, is a dimeric analog of enkephalin with a high affinity for opioid receptors. Opioid receptors are widespread in the central nervous system and in peripheral neuronal and non-neuronal tissues. Hence, these recepto
Externí odkaz:
https://doaj.org/article/41740137bacd43639e4b74778aaf135b