Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Aleksandra, Galetin"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 524-543 (2024)
Abstract Organ‐on‐a‐chip (OoC) systems are a promising new class of in vitro devices that can combine various tissues, cultured in different compartments, linked by media flow. The properties of these novel in vitro systems linked to increased
Externí odkaz:
https://doaj.org/article/416f8c0008364f0abef0e77f37f7a341
Autor:
Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 467-477 (2021)
Abstract Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs). Pyridoxic acid (PDA) and homovanillic acid (HVA) were indicated as potenti
Externí odkaz:
https://doaj.org/article/5bf2ee103c154af4818724a4d2d8a5c3
Autor:
Hiroyuki Takita, Shelby Barnett, Yueping Zhang, Karelle Ménochet, Hong Shen, Kayode Ogungbenro, Aleksandra Galetin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 137-147 (2021)
Coproporphyrin I (CPI) is an endogenous biomarker of OATP1B activity and associated drug‐drug interactions. In this study, a minimal physiologically‐based pharmacokinetic model was developed to investigate the impact of OATP1B1 genotype (c.521T>C
Externí odkaz:
https://doaj.org/article/bcb3eb0e26ae41549ab32adc6ba6bc94
Autor:
Nicola Melillo, Daniel Scotcher, J. Gerry Kenna, Claudia Green, Catherine D. G. Hines, Iina Laitinen, Paul D. Hockings, Kayode Ogungbenro, Ebony R. Gunwhy, Steven Sourbron, John C. Waterton, Gunnar Schuetz, Aleksandra Galetin
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 896 (2023)
Gadoxetate, a magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 and multidrug resistance-associated protein 2. Six drugs, with varying degrees of transporter inhibition, were used to assess
Externí odkaz:
https://doaj.org/article/ad3d7aef2cea4895a8dd3d1fd0b8d311
Autor:
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 6, Pp 310-321 (2020)
Creatinine is the most common clinical biomarker of renal function. As a substrate for renal transporters, its secretion is susceptible to inhibition by drugs, resulting in transient increase in serum creatinine and false impression of damage to kidn
Externí odkaz:
https://doaj.org/article/f53d92566d8140cea8c3748fb8b68d01
Autor:
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew‐Mei Huang, Amin Rostami‐Hodjegan, Aleksandra Galetin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 5, Pp 282-293 (2020)
Creatinine is widely used as a biomarker of glomerular filtration, and, hence, renal function. However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a lesser degree. Inhibition of these transporters causes trans
Externí odkaz:
https://doaj.org/article/a73aaba8c1184e2e9e73af246614abb7
Autor:
Hiroyuki Takita, Daniel Scotcher, Xiaoyan Chu, Ka Lai Yee, Kayode Ogungbenro, Aleksandra Galetin
Publikováno v:
Takita, H, Scotcher, D, Chu, X, Yee, K L, Ogungbenro, K & Galetin, A 2022, ' Coproporphyrin I as an endogenous biomarker to detect reduced OATP1B activity and shift in elimination route in chronic kidney disease ', Clinical Pharmacology & Therapeutics . https://doi.org/10.1002/cpt.2672
Coproporphyrin I (CPI) is an endogenous biomarker of organic anion transporting polypeptides 1B transporter (OATP1B). CPI plasma baseline was reported to increase with severity of chronic kidney disease (CKD). Further, ratio of CPI area under the pla
Autor:
Luca Docci, Nicolò Milani, Thomas Ramp, Andrea A. Romeo, Patricio Godoy, Daniela Ortiz Franyuti, Stephan Krähenbühl, Michael Gertz, Aleksandra Galetin, Neil Parrott, Stephen Fowler
Publikováno v:
Docci, L, Milani, N, Ramp, T, Romeo, A A, Godoy, P, Franyuti, D O, Krähenbühl, S, Gertz, M, Galetin, A, Parrott, N & Fowler, S 2022, ' Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies ', Lab on a Chip, vol. 22, no. 6, pp. 1187-1205 . https://doi.org/10.1039/D1LC01161H
Microphysiological systems (MPS) are complex and more physiologically realistic cellular in vitro tools that aim to provide more relevant human in vitro data for quantitative prediction of clinical pharmacokinetics while also reducing the need for an
Autor:
Nicoló Milani, Neil Parrott, Daniela Ortiz Franyuti, Patricio Godoy, Aleksandra Galetin, Michael Gertz, Stephen Fowler
Publikováno v:
Lab on a Chip. 22:2853-2868
Gut–liver MPS offer attractive opportunities to study absorption and metabolism processes for orally administered drugs, especially prodrugs. Modelling and simulation must be included from the outset for robust study design and parameter generation
Autor:
Zubida M. Al-Majdoub, Aleksandra Galetin, Jill Barber, Amin Rostami-Hodjegan, Brahim Achour, Daniel Scotcher
Publikováno v:
Al-Majdoub, Z, Scotcher, D, Achour, B, Barber, J, Galetin, A & Rostami-Hodjegan, A 2021, ' Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics ', Clinical Pharmacology & Therapeutics, vol. 110, no. 5, pp. 1389-1400 . https://doi.org/10.1002/cpt.2396
The applications of translational modelling of local drug concentrations in various organs had a sharp increase over the last decade. These are part of the 'Model-Informed Drug Development' (MIDD) initiative, adopted by the pharmaceutical industry an