Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aleksandr V, Yurkovetskiy"'
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak
These are figures associated with a second manuscript that has been submitted for consideration for co-publication. It describes the platform and hopefully will facilitate the reviewers' assessment of this manuscript on XMT-1536. we are also happy to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5b872009cdfca855c9f02d87127d20
https://doi.org/10.1158/1535-7163.22522738
https://doi.org/10.1158/1535-7163.22522738
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak
These are figures associated with a second manuscript that has been submitted for consideration for co-publication. It describes the platform and hopefully will facilitate the reviewers' assessment of this manuscript on XMT-1536. we are happy to make
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7da7268afac65c3294d060c5e6c69b
https://doi.org/10.1158/1535-7163.22522741
https://doi.org/10.1158/1535-7163.22522741
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Peter U. Park, Qingxiu Zhang, Ling Xu, Marina Protopopova, Laura L. Poling, Michael J. DeVit, Dennis McGillicuddy, Venu R. Gurijala, Alex J. Johnson, Charlie Bu, Elena Ter-Ovanesyan, Dmitry R. Gumerov, LiuLiang Qin, Alex Uttard, Cheri A. Stevenson, Patrick R. Conlon, Susan M. Clardy, Joshua D. Thomas, Mao Yin, Natalya D. Bodyak, Aleksandr V. Yurkovetskiy
Supplementary methods, data and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650945d96b4cb4ca36cc61fe8daa399d
https://doi.org/10.1158/1535-7163.22522479
https://doi.org/10.1158/1535-7163.22522479
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Jian Xu, Dongmei Xiao, Alex Uttard, Elena Ter-Ovanesyan, Cheri A. Stevenson, LiuLiang Qin, Marina Protopova, Laura L. Poling, Peter U. Park, Dennis McGillicuddy, Winnie Lee, Venu R. Gurijala, Dmitry R. Gumerov, Michael J. DeVit, Damon R. Demady, Patrick R. Conlon, Charlie Bu, Mao Yin, Aleksandr V. Yurkovetskiy, Rebecca Mosher, Natalya D. Bodyak
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f84d8d23561ce01710afb14c790013
https://doi.org/10.1158/1535-7163.22522732
https://doi.org/10.1158/1535-7163.22522732
Autor:
Timothy B. Lowinger, Donald A. Bergstrom, Peter U. Park, Qingxiu Zhang, Ling Xu, Marina Protopopova, Laura L. Poling, Michael J. DeVit, Dennis McGillicuddy, Venu R. Gurijala, Alex J. Johnson, Charlie Bu, Elena Ter-Ovanesyan, Dmitry R. Gumerov, LiuLiang Qin, Alex Uttard, Cheri A. Stevenson, Patrick R. Conlon, Susan M. Clardy, Joshua D. Thomas, Mao Yin, Natalya D. Bodyak, Aleksandr V. Yurkovetskiy
After significant effort over the last 30 years, antibody–drug conjugates (ADC) have recently gained momentum as a therapeutic modality, and nine ADCs have been approved by the FDA to date, with additional ADCs in late stages of development. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951b8c25dbbe73e1c85ae90ec75bc178
https://doi.org/10.1158/1535-7163.c.6543396
https://doi.org/10.1158/1535-7163.c.6543396
Autor:
Patrick R. Conlon, Venu Reddy Gurijala, Michael Kaufman, Dachang Li, Jiuyuan Li, Yuanyuan Li, Mao Yin, Bollu Satyanarayan Reddy, Thomas Wagler, Zedong Wang, Zhongmin Xu, Aleksandr V. Yurkovetskiy, Lei Zhu
Publikováno v:
Organic Process Research & Development. 26:2124-2137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab9d64e269ee184a50df4a1b781d1bb
https://doi.org/10.1021/acs.oprd.1c00449
https://doi.org/10.1021/acs.oprd.1c00449
Autor:
Joshua D, Thomas, Aleksandr V, Yurkovetskiy, Mao, Yin, Natalya D, Bodyak, Dmitry R, Gumerov, Shuyi, Tang, Eoin, Kelleher, Brian D, Jones, Marina, Protopopova, LiuLiang, Qin, Alex, Uttard, Damon R, Demady, Timothy B, Lowinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128876
Pyrrolobenzodiazepine (PBD) dimers are well-known highly potent antibody drug conjugate (ADC) payloads. The corresponding PBD monomers, in contrast, have received much less attention from the ADC community. We prepared several novel polyamide-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c28732d20f05570a4c9c7504b2fae53
https://doi.org/10.1016/j.bmcl.2022.128876
https://doi.org/10.1016/j.bmcl.2022.128876
Autor:
Donald A. Bergstrom, Cheri A. Stevenson, Venu R. Gurijala, Ling Xu, Dongmei Xiao, Timothy B. Lowinger, Mao Yin, Jian Xu, Aleksandr V. Yurkovetskiy, Peter U. Park, Winnie Lee, Patrick R. Conlon, Charlie Bu, Dennis McGillicuddy, Damon R. Demady, Rebecca Mosher, Elena Ter-Ovanesyan, Laura L. Poling, Michael J. DeVit, Alex Uttard, Natalya D. Bodyak, Dmitry R. Gumerov, Marina Protopova, LiuLiang Qin
Publikováno v:
Molecular cancer therapeutics. 20(5)
Target selection for antibody–drug conjugates (ADC) frequently focuses on identifying antigens with differential expression in tumor and normal tissue, to mitigate the risk of on-target toxicity. However, this strategy restricts the possible target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c97f519956a37e7d6ea447a76acbecb
https://pubmed.ncbi.nlm.nih.gov/33722858
https://pubmed.ncbi.nlm.nih.gov/33722858
Autor:
Venu R. Gurijala, Joshua D. Thomas, Cheri A. Stevenson, Dmitry R. Gumerov, Dennis McGillicuddy, Aleksandr V. Yurkovetskiy, LiuLiang Qin, Laura L. Poling, Alex Johnson, Timothy B. Lowinger, Donald A. Bergstrom, Ling Xu, Peter U. Park, Marina Protopopova, Elena Ter-Ovanesyan, Natalya D. Bodyak, Patrick R. Conlon, Michael J. DeVit, Alex Uttard, Charlie Bu, Qingxiu Zhang, Mao Yin, Susan M. Clardy
Publikováno v:
Molecular cancer therapeutics. 20(5)
After significant effort over the last 30 years, antibody–drug conjugates (ADC) have recently gained momentum as a therapeutic modality, and nine ADCs have been approved by the FDA to date, with additional ADCs in late stages of development. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edd41dba66c5c6d946fa5f9db888342
https://pubmed.ncbi.nlm.nih.gov/33722857
https://pubmed.ncbi.nlm.nih.gov/33722857
Autor:
Timothy B. Lowinger, Jeremy M. Sen, William C. Zamboni, Robert Fram, Suzan K. Hanna, Aleksandr V. Yurkovetskiy, Carolina B. Cabral, S. Rawal, Mark D. Walsh
Publikováno v:
Clinical Cancer Research. 18:2591-2602
Purpose: To evaluate the pharmacokinetics and tissue disposition of macromolecular camptothecin (CPT) drug conjugate, XMT-1001, and irinotecan (CPT-11) in mice bearing HT-29 xenograft tumors. Experimental Design: The antitumor efficacy of XMT-1001 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6478fb8744ed95cad98b99e50ea6e9f
https://doi.org/10.1158/1078-0432.ccr-11-1554
https://doi.org/10.1158/1078-0432.ccr-11-1554