Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Aleksandr V, Denisenko"'
Autor:
Valeriya Shcherbakova, Pavel K. Mykhailiuk, Yevhen Skalenko, Dmitry Dibchak, Mariya Snisarenko, Aleksandr V. Denisenko, Anastasiia S. Kuznetsova
Publikováno v:
The Journal of Organic Chemistry. 86:2200-2209
A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemistry-is developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e3a1efc810431aab90ac328511dcdc3
https://doi.org/10.1021/acs.joc.0c02355
https://doi.org/10.1021/acs.joc.0c02355
Publikováno v:
ARKIVOC, Vol 2012, Iss 8, Pp 226-230 (2012)
Externí odkaz:
https://doaj.org/article/17e3eb3852a743d7995acf8bef7483b7
Autor:
Valeriya, Shcherbakova, Dmitry, Dibchak, Mariya, Snisarenko, Yevhen, Skalenko, Aleksandr V, Denisenko, Anastasiia S, Kuznetsova, Pavel K, Mykhailiuk
Publikováno v:
The Journal of organic chemistry. 86(3)
A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemistry-is developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5094c7e89db5be19889ed5f3c7731b9d
https://pubmed.ncbi.nlm.nih.gov/33211487
https://pubmed.ncbi.nlm.nih.gov/33211487
Autor:
Pavel K. Mykhailiuk, Nataliya M. Voloshchuk, Svetlana V. Shishkina, Pavel Garbuz, Aleksandr V. Denisenko
Publikováno v:
Angewandte Chemie (International ed. in English). 59(46)
Saturated bioisosteres of ortho-disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57de5104b5d488606b3dbab46062dbcb
https://pubmed.ncbi.nlm.nih.gov/32662201
https://pubmed.ncbi.nlm.nih.gov/32662201
Autor:
Oleksandr P. Dacenko, Yevhen Skalenko, Pavel K. Mykhailiuk, Andrey A. Tolmachev, Maryna Samoilenko, Oleksandr O. Grygorenko, Serhii A. Trofymchuk, Aleksandr V. Denisenko, Tetiana V. Druzhenko
Publikováno v:
The Journal of Organic Chemistry. 83:6275-6289
A one-step synthesis of functionalized 3-azabicyclo[3.2.0]heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was elaborated. The obtained compounds were easily transformed into the bi- and tricyclic analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ff5eb1c1947f38609346527fe0dbdd
https://doi.org/10.1021/acs.joc.8b00077
https://doi.org/10.1021/acs.joc.8b00077
Autor:
Yevhen Skalenko, Pavel K. Mykhailiuk, Maryna Samoilenko, Petro Borysko, Alexandr Tarasov, Sergey Zozulya, Maria I. Sokolenko, Aleksandr V. Denisenko, Tetiana V. Druzhenko
Publikováno v:
The Journal of Organic Chemistry. 83:1394-1401
Intramolecular photochemical [2 + 2]-cyclization of acetophenone enamides gave 2-azabicyclo[3.2.0]heptanes, advanced building blocks for drug discovery. Synthesis of a conformationally restricted analogue of proline, 2,3-ethanoproline, was performed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c364b4d46a76a616d5ea86e2cb0dfa
https://doi.org/10.1021/acs.joc.7b02910
https://doi.org/10.1021/acs.joc.7b02910
Publikováno v:
Organic letters. 21(22)
Synthesis of the previously unknown conformationally rigid sultams fused with the cyclobutane ring was developed. The key transformation was an intramolecular photochemical cyclization of linear sulfonamides. Crystallographic analysis showed that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da231b4c35cabf36f5ca794072c8db25
https://pubmed.ncbi.nlm.nih.gov/31603689
https://pubmed.ncbi.nlm.nih.gov/31603689
Autor:
Maryna Samoilenko, Oleksandr O. Grygorenko, Yevhen Skalenko, Pavel K. Mykhailiuk, Tetiana V. Druzhenko, Sergey Zozulya, Aleksandr V. Denisenko
Publikováno v:
The Journal of organic chemistry. 82(18)
We have developed a rapid two-step synthesis of substituted 3-azabicyclo[3.2.0]heptanes which are attractive building blocks for drug discovery. This new method utilizes very common chemicals, benzaldehyde, allylamine, and cinnamic acid, via intramol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a326b76ff541734e5bfb6f9c7bdb4f
https://pubmed.ncbi.nlm.nih.gov/28810741
https://pubmed.ncbi.nlm.nih.gov/28810741
Publikováno v:
ARKIVOC, Vol 2012, Iss 8, Pp 226-230 (2012)
A practical synthetic procedure for the synthesis of dihydro-2H-pyran-3(4H)-one is reported. The method commenced from the readily available -ketoglutaric acid and allowed preparation of the title compound in four steps in 31% overall yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5acc3e102d333231654e01008017b5
https://doi.org/10.3998/ark.5550190.0013.820
https://doi.org/10.3998/ark.5550190.0013.820
Autor:
Oleg V. Shishkin, Aleksandr V. Denisenko, Pavel K. Mykhailiuk, Andrey P. Mityuk, Oleksandr O. Grygorenko, Dmitriy M. Volochnyuk, Oleksandr P. Dacenko, Andrey A. Tolmachev
Publikováno v:
Synthesis. 2010:493-497
Chlorotrimethylsilane-promoted double Mannich annulation of ketonesusing N, N-bis(methoxymethyl)benzylaminehas been explored. It has been shown that the structure of the substrate drasticallyinfluenced the outcome of the reaction. The method allows a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57096a6ad796b8d9233e33db660616a9
https://doi.org/10.1055/s-0029-1217137
https://doi.org/10.1055/s-0029-1217137