Výsledky vyhledávání - "Aleksandr Obikhod"

Evaluation of Single and Combination Therapies with Tenofovir Disoproxil Fumarate and Emtricitabine In Vitro and in a Robust Mouse Model Supporting High Levels of Hepatitis B Virus Replication

Autor: Leda Bassit, Aleksandr Obikhod, Marcia M. Clayton, Alla Arzumanyan, Raymond F. Schinazi, James J. Kohler, Mark A. Feitelson, Bill N. C. Sun

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:6186-6191

Next-generation therapies for chronic hepatitis B virus (HBV) infection will involve combinations of established and/or experimental drugs. The current study investigated the in vitro and in vivo efficacy of tenofovir disoproxil fumarate (TDF) and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0920a9ca90a9575a76f0eead9757a50
https://doi.org/10.1128/aac.01483-12

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Telbivudine Exerts no Antiviral Activity against HIV-1 In Vitro and in Humans

Autor: Andy I. M. Hoepelman, Dorien de Jong, Noortje M van Maarseveen, Greg L. Beilhartz, Raymond F. Schinazi, Annemarie M. J. Wensing, Joop E. Arends, Aleksandr Obikhod, Matthias Götte, Monique Nijhuis, Sijia Tao, Marieke Pingen

Publikováno v: Antivir Ther

Background HIV–HBV-coinfected individuals who need to be treated only for their HBV infection have limited therapeutic options, since most approved anti-HBV agents have a risk of selecting for drug-resistant HIV mutants. In vivo data are inconclusi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4884452b617a263468d1e865773992d9
https://doi.org/10.3851/imp1912

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Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3′-azido-2′,3′-dideoxyguanosine-5′-triphosphates as adenosine analogs

Autor: Ugo Pradere, Aleksandr Obikhod, Hongwang Zhang, John W. Mellors, Raymond F. Schinazi, Richard A. Stanton, Nicolas Sluis-Cremer, James H. Nettles, Steven J. Coats, Mervi Detorio, Brian D. Herman

Publikováno v: Nucleic Acids Research

β-D-3'-Azido-2',3'-dideoxyguanosine (3'-azido-ddG) is a potent inhibitor of HIV-1 replication with a superior resistance profile to zidovudine. Recently, we identified five novel 6-modified-3'-azido-ddG analogs that exhibit similar or superior anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3344fdd3ab4083885c46dceb15b688e
http://europepmc.org/articles/PMC3245946

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Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides

Autor: Steven J. Coats, Hongwang Zhang, Raymond F. Schinazi, Mervi Detorio, Brian D. Herman, James H. Nettles, John W. Mellors, Sarah Solomon, Aleksandr Obikhod, Sijia Tao, Nicolas Sluis-Cremer, Leda Bassit

Publikováno v: European Journal of Medicinal Chemistry. 46:3832-3844

Microwave-assisted optimized transglycosylation reactions were used to prepare eleven modified l-3'-azido-2',3'-dideoxypurine nucleosides. These l-nucleoside analogs were evaluated against HIV and hepatitis B virus. The l-3'-azido-2',3'-dideoxypurine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2007f60ac9724aea750a59184967e9
https://doi.org/10.1016/j.ejmech.2011.05.051

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Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides

Autor: Brian D. Herman, Luigi A. Agrofoglio, Nicolas Sluis-Cremer, Raymond F. Schinazi, Vincent Roy, Steven J. Coats, Hongwang Zhang, Aleksandr Obikhod

Publikováno v: Nucleosides Nucleotides Nucleic Acids

A series of hitherto unknown 3′-α-[1,2,3]-substituted triazolo-2′,3′-dideoxypyrimidine nucleoside analogues of the anti-HIV 3′-azido-3′-deoxythymidine (AZT) were synthesized through catalyzed alkyne-azide 1,3-dipolar cycloaddition (Huisgen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c7050d6f6475f8059cef977f87dbf9
https://doi.org/10.1080/15257770.2011.580291

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Simultaneous Quantification of Intracellular Natural and Antiretroviral Nucleosides and Nucleotides by Liquid Chromatography−Tandem Mass Spectrometry

Autor: Raymond F. Schinazi, Aleksandr Obikhod, Christina Gavegnano, Emilie Fromentin

Publikováno v: Analytical Chemistry. 82:1982-1989

Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human immunodeficiency virus type 1 (HIV-1). NRTI-triphosphates (NRTI-TP) compete with endogenous 2'-deox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5e087860bb5863df1f5b38a3ecc977
https://doi.org/10.1021/ac902737j

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Simultaneous quantification of 9-(β-d-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography–tandem mass spectrometric assay

Autor: Ghazia Asif, Emilie Fromentin, Aleksandr Obikhod, Selwyn J. Hurwitz, Raymond F. Schinazi

Publikováno v: Journal of Chromatography B. 877:3482-3488

A sensitive method was developed and validated for simultaneous measurement of an investigational antiviral nucleoside, Amdoxovir (DAPD), its deaminated metabolite 9-(β- d -1,3-dioxolan-4-yl)guanine (DXG), and Zidovudine (ZDV) in human plasma. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3f5aa11c9d759de99d27736928074b
https://doi.org/10.1016/j.jchromb.2009.08.030

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Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase

Autor: Raymond F. Schinazi, Aleksandr Obikhod, Matthias Götte, Egor P. Tchesnokov

Publikováno v: Journal of Biological Chemistry. 283:34218-34228

Entecavir (ETV) is a potent antiviral nucleoside analogue that is used to treat hepatitis B virus (HBV) infection. Recent clinical studies have demonstrated that ETV is also active against the human immunodeficiency virus type 1 (HIV-1). Unlike all a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4fda446bd5d7762e60ee13a55ed2db
https://doi.org/10.1074/jbc.m806797200

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Pre-steady-state Kinetic Studies Establish Entecavir 5′-Triphosphate as a Substrate for HIV-1 Reverse Transcriptase

Autor: Moira A. McMahon, Kimberly L. Rapp, Julian Tirado-Rives, Karen S. Anderson, Raymond F. Schinazi, Christopher M. Bailey, Chloe L. Thio, Robert F. Siliciano, Aleksandr Obikhod, Mervi Detorio, Robert A. Domaoal

Publikováno v: J Biol Chem

The novel 2'-deoxyguanosine analog Entecavir (ETV) is a potent inhibitor of hepatitis B virus (HBV) replication and is recommended for treatment in human immunodeficiency virus type 1 (HIV-1) and HBV-co-infected patients because it had been reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f967b7cf26ab2ca972693ffec147b2ae
https://doi.org/10.1074/jbc.m707834200

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Cellular Pharmacology of 9-(β-D-1,3-dioxolan-4-yl) Guanine and its Lack of Drug Interactions with Zidovudine in Primary Human Lymphocytes

Autor: Emilie Fromentin, Raymond F. Schinazi, Brenda I. Hernandez-Santiago, Selwyn J. Hurwitz, Aleksandr Obikhod

Publikováno v: Antiviral Chemistry and Chemotherapy. 18:343-346

Amdoxovir, currently in Phase II clinical trials, is rapidly converted to 9-(β-D-1,3-dioxolan-4-yl)guanine (DXG) by adenosine deaminase in vitro and in humans. The cellular pharmacology of DXG in primary human lymphocytes, including dose-response re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5144508cd36db8aec4270ff21724b689
https://doi.org/10.1177/095632020701800606

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