Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aleksandr, Dolgoter"'
Autor:
James A. Harker, Trever T. Greene, Burton E. Barnett, Phuc Bao, Aleksandr Dolgoter, Elina I. Zuniga
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The IL-6 cytokine family signals through the common signal transduction molecule gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with lymphocytic choriomeningitis viru
Externí odkaz:
https://doaj.org/article/50f2afff8074497a9c4c07c1865892ed
Publikováno v:
J Immunol
Journal of immunology (Baltimore, Md. : 1950), vol 203, iss 6
Journal of immunology (Baltimore, Md. : 1950), vol 203, iss 6
The pleiotropic cytokine IL-6 plays an integral role not only in innate inflammatory responses but also in the activation and differentiation of lymphocyte subsets. In this study, by using a conditional knockout (cKO) model with selective IL-6 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236495b147f973c573fa69c1fe42e9e0
https://doi.org/10.4049/jimmunol.1801567
https://doi.org/10.4049/jimmunol.1801567
Autor:
James A, Harker, Kurt A, Wong, Simone, Dallari, Phuc, Bao, Aleksandr, Dolgoter, Yeara, Jo, Ellen J, Wehrens, Monica, Macal, Elina I, Zuniga
Publikováno v:
Journal of Virology
Chronic viral infections represent a major challenge to the host immune response, and a unique network of immunological elements, including cytokines, are required for their containment. By using a model persistent infection with the natural murine p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::623341657fb10d3302b608dc6fd7eb0d
https://pubmed.ncbi.nlm.nih.gov/29593047
https://pubmed.ncbi.nlm.nih.gov/29593047
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(3)
The IL-6 cytokine family utilizes the common signal transduction molecule gp130, which can mediate a diverse range of outcomes. To clarify the role of gp130 signaling in vivo during acute viral infection, we infected Cd4-cre Il6stfl/fl mice, in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72b08632bcb55a043ba9bf2c3a73b7
https://pubmed.ncbi.nlm.nih.gov/26085685
https://pubmed.ncbi.nlm.nih.gov/26085685
SummaryThe outcome of chronic viral infections, which affect millions of people worldwide, is greatly dependent on CD4+ T cells. Here we showed that T cell-specific ablation of the common interleukin-6 (IL-6) family receptor, gp130, profoundly compro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b408b977cde16a5ca1e7256516b8b9a
https://europepmc.org/articles/PMC4701058/
https://europepmc.org/articles/PMC4701058/
Publikováno v:
The Journal of Immunology. 192:208.7-208.7
Chronic viral infections such as human immunodeficiency virus 1 and hepatitis C virus represent a significant global health burden. Virus specific CD4+ T cell number and function are critical in determining the outcome of these chronic viral infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556b2d319950ffa9fadc02710806ab11
https://doi.org/10.4049/jimmunol.192.supp.208.7
https://doi.org/10.4049/jimmunol.192.supp.208.7
Publikováno v:
The Journal of Immunology. 190:173.19-173.19
Infection with chronic viral infections such as human immunodeficiency virus-1 and hepatitis C virus significantly increases the risk of developing cancer. CD4 T cells number and function are critical in determining the outcome of chronic viral infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e79e56512df83cedbbff90aae57662e
https://doi.org/10.4049/jimmunol.190.supp.173.19
https://doi.org/10.4049/jimmunol.190.supp.173.19