Tenecteplase Versus Alteplase in Medium Vessel Occlusion Ischemic Stroke: A Secondary Analysis of the Alteplase Compared to Tenecteplase Randomized Trial

Autor: Fouzi Bala, Nishita Singh, Katrina Ignacio, Ibrahim Alhabli, Ayoola Ademola, Anas Alrohimi, Houman Khosravani, Aleksander Tkach, Luciana Catanese, Dariush Dowlatshahi, Thalia Field, Gary Hunter, Faysal Benali, MacKenzie Horn, Andrew Demchuk, Michael Hill, Tolulope Sajobi, Brian Buck, Richard Swartz, Mohammed Almekhlafi, Bijoy K. Menon

Publikováno v: Journal of Stroke, Vol 26, Iss 2, Pp 280-289 (2024)

Background and Purpose The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with alteplase in stroke due to MeVO. Methods Patients with b

Externí odkaz: https://doaj.org/article/e668bfe16b034a51bea2709ffe84cc33

Understanding Physician and Patient Preferences for Thrombolysis in Ischemic Stroke Eligible for Endovascular Thrombectomy

Autor: Nishita Singh, Nima Kashani, Aravind Ganesh, Carol Kenney, David Ben‐Israel, Raed Joundi, Aristeidis H. Katsanos, Anas Alrohimi, Fouzi Bala, Michel Shamy, Aleksander Tkach, Richard H. Swartz, Brian H. Buck, Andrew M. Demchuk, Michael D. Hill, Kednapa Thavorn, Tolulope Sajobi, Mohammed Almekhlafi, Dar Dowlatshahi, Bijoy K. Menon

Publikováno v: Stroke: Vascular and Interventional Neurology, Vol 2, Iss 3 (2022)

Background In light of evidence from recent trials that endovascular thrombectomy (EVT) alone may potentially be noninferior to combined treatment, that is, with intravenous thrombolysis (IVT) with alteplase and EVT, we sought to understand physician

Externí odkaz: https://doaj.org/article/db528ec7188742559c1610c1ffeb3ada

Effect of Time to Thrombolysis on Clinical Outcomes in Patients with Acute Ischemic Stroke Treated with Tenecteplase Compared to Alteplase: Analysis from the AcT Randomized Controlled Trial

Autor: Nishita Singh, Mohammed Almekhlafi, Fouzi Bala, Ayoola Ademola, Shelagh B. Coutts, Yan Deschaintre, Houman Khosravani, Brian Buck, Ramana Appireddy, Francois Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Jai Shankar, Esseeddeegg Ghrooda, Alexandre Y. Poppe, Heather Williams, Thalia S. Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhoude, Gary Hunter, Michel Shamy, Andrew M. Demchuk, Brian Claggett, Michael D. Hill, Tolulope T. Sajobi, Richard H. Swartz, Bijoy K. Menon

BackgroundThe Alteplase compared to Tenecteplase (AcT) randomized controlled trial (RCT) showed that tenecteplase is non-inferior to alteplase in treating acute ischemic stroke within 4.5 hours of symptom onset. The effect of time to treatment on cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dba1c55ed5f0cee86da050602b0fcf6a
https://doi.org/10.1101/2023.05.17.23290141

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Autor: Bijoy K Menon, Brian H Buck, Nishita Singh, Yan Deschaintre, Mohammed A Almekhlafi, Shelagh B Coutts, Sibi Thirunavukkarasu, Houman Khosravani, Ramana Appireddy, Francois Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Thalia S Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Andrew M Demchuk, Sachin Mishra, Laura C Gioia, Shirin Jalini, Caroline Cayer, Stephen Phillips, Elsadig Elamin, Ashkan Shoamanesh, Suresh Subramaniam, Mahesh Kate, Gregory Jacquin, Marie-Christine Camden, Faysal Benali, Ibrahim Alhabli, Fouzi Bala, MacKenzie Horn, Grant Stotts, Michael D Hill, David J Gladstone, Alexandre Poppe, Arshia Sehgal, Qiao Zhang, Brendan Cord Lethebe, Craig Doram, Ayoola Ademola, Michel Shamy, Carol Kenney, Tolulope T Sajobi, Richard H Swartz, Abhilekh Srivastava, Ahmed M Aljammaz, Akintomide Femi Akindotun, Albert Y Jin, Alexander Fraser, Alexander V Khaw, Alexandru Lemnaru, Alisia Southwell, Alnar Ramji, Alonso Alvarado-Bolaños, Amr Mouminah, Amro B Lahlouh, Amy Y Yu, Anas Alrohimi, Andre Lavoie, Andrea Rogge, Andrew Micieli, Andrew Linh Nguyen, Angelique Callaghan-Brown, Anita Florendo-Cumbermack, Ankur Wadhwa, Ann-Marie Beaudoin, Anne Cayley, Anne Marie Liddy, Anurag Trivedi, Aristeidis H Katsanos, Ashfaq Shuaib, Asif Javed Butt, Olena Bereznyakova, Beth Beauchamp, Breane Mahlitz, Brett R Graham, Brian Dewar, Bryce A Durafourt, Caitlin Holtby, Caitlin S Jackson-Tarlton, Caitlyn Bockus, Caroline Stephenson, Camille Galloway, Céline Odier, Charles Deacon, Charlotte Zerna, Chetan C Vekhande, Christian Bocti, Christian Stapf, Christine Hawkes, Christine Anne Stables, Chrysi Bogiatzi, Claudia Rodriguez, Claudia Candale-Radu, Colleen Murphy, Courtney Sarah Casserly, Daniel Fok, Danielle de Sa Boasquevisque, Daryl Wile, David Volders, Demetrios J Sahlas, Elaine Shand, Elena Adela Cora, Eliane Di Battista, Eileen Stewart, Emily Junk, Emma L Harrison, Eric Frenette, Ericka Teleg, Eslam Abdellah, Esseddeeg Ghrooda, Farhana Akthar, François Evoy, Gary M Klein, Genoveva Maclean, Glen C Jickling, Glenda Hawthorne, Gordon Boyd, Gregory Walker, Gustavo Saposnik, H Lee Lau, Hanan E Badr, Hassanain Toma, Hayrapet Kalashyan, Hugo Marion-Moffet, Ian Grant, Idris Fatakdawala, Isabelle Beaulieu-Boire, Janice Williams, Jaskiran Brar, Jean Rivest, Jeffrey Z Wang, Jessica Dawe, Jillian Stang, Joanne Day, Jodi Miller, Johnathon Gorman, Julia Jasmine Hopyan, Julian Lee, Julie Kromm, Kaitlyn Foster, Kanchana Ratnayake, Kanjana S Perera, Karina Villaluna Murray, Karla Ryckborst, Katie Lin, Kayla Sage, Keithan Sivakuma, Kelly A MacDonald, Kelvin Kuan Ng, Ketki Merchant, Khurshid Khan, Kimia Ghavami, Kyra Johnston, Lauren M Mai, Leah White, Lee Barratt, Linda Longpre, Lisa Crellin, Lissa Peeling, Lori Piquette, Lysa Boissé Lomax, Mahsa Sadeghi, Maneesha Kamra, Manuel Lavoie-April, Margaret Moores, Maria Bres Bullrich, Marie McClelland, Marina Salluzzi, Mark Wilcox, Mark I Boulos, Martha Marko, Matthew Boyko, Maude Lantagne-Hurtubise, May Adel AlHamid, Mays Shawawrah, Michael E Kelly, Michael W D Thorne, Miguel Bussiere, Ming Yin Dominc Tse, Mowad Benguzzi, Mukul Sharma, Myles Horton, Nancy Newcommon, Nandy-Shelwine Simon, Natalie E Parks, Nazeem Sultan, Nevena Markovic, Nicole Daneault, Noman Ishaque, Paige Fairall, Pawel B Kostyrko, Peter K Stys, Philip Teal, Philippe Couillard, Princess King-Azote, Quentin Collier, Rachel Epp, Radhika Nair, Raed A Joundi, Rajive Jassal, Raphael Schneider, Reza Hosseini, Rosalie Bouchard, Ruth Whelan, S Regan Cooley, Sajeevan Sujanthan, Salman Mansoor, Samuel Yip, Sanchea Wasyliw, Sean W. Taylor, Sebastian Friedman, Sharan Mann, Sharleen Weese Maley, Sherry Chiasson, Sherry Xueying Hu, Shorog Althubait, Shuhira Himed, Shuo Chen, Simerpreet S Bal, Stacey A Page, Stacey D Beck, Stephanie Woodroffe, Stephanie D Reiter, Stephen van Gaal, Steven Ray Peters, Sultan Darvesh, Supriya Save, Susan Alcock, Susannah Piercey, Suzie Adam, Sylvie Gosselin, Tess Fitzpatrick, Thomas-Louis Perron, Tim Stewart, Timothy J Benstead, Vishaya Naidoo, Wasan Abd Wahab, Wiesław Oczkowski, William Kingston, William Leduc, William T H To, Yeyao Joe Yu, Zhongyu A Liu, Ziad Ezzat Aljundi

Publikováno v: Lancet (London, England). 400(10347)

Intravenous thrombolysis with alteplase bolus followed by infusion is a global standard of care for patients with acute ischaemic stroke. We aimed to determine whether tenecteplase given as a single bolus might increase reperfusion compared with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc5e53429743ba8fd155e21c582c468
https://pubmed.ncbi.nlm.nih.gov/35779556

Genome-wide association study identifies first locus associated with susceptibility to cerebral venous thrombosis

Autor: Serena M. Passamonti, Aleksander Tkach, José M. Ferro, Susanna M. Zuurbier, Stéphanie Debette, Pankaj Sharma, Christina Jern, Ida Martinelli, Elena Haapaniemi, Patrícia Canhão, Braxton D. Mitchell, Giovanni Favuzzi, Guillaume Paré, Alessandro Pezzini, Antonio Arauz, Erik Lindgren, Donatella Colaizzo, Aude Bagan Triquenot, Véronique Le Cam Duchez, K. Spengos, Marina Colombi, Jonathan M. Coutinho, Rosa Santacroce, Paolo Bucciarelli, B. B. Worrall, Ioana Cotlarciuc, Jukka Putaala, Paolo Costa, Reina Ditta, Maurizio Margaglione, Emanuela Pappalardo, Tiina M. Metso, Jennifer J. Majersik, Steven J. Kittner, Turgut Tatlisumak, Sini Hiltunen, Michelangelo Mancuso, Elvira Grandone, Amanda Hodge, Robin Lemmens, Katarina Jood, Marialuisa Zedde, Matthijs C. Brouwer, Sofia Leal Rodrigues, Gie Ken-Dror, Thomas Marjot, Ynte M. Ruigrok, Maria Abbattista, Diana Aguiar de Sousa, Vincent Thijs

Publikováno v: Annals of Neurology
Annals of Neurology, Wiley, 2021, ⟨10.1002/ana.26205⟩
Ann Neurol
Annals of neurology, 90(5), 777-788. John Wiley and Sons Inc.

Objective Cerebral venous thrombosis (CVT) is an uncommon form of stroke affecting mostly young individuals. Although genetic factors are thought to play a role in this cerebrovascular condition, its genetic etiology is not well understood. Methods A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48a366d0ee2c2bf1d91d2731b195c57
https://hal.archives-ouvertes.fr/hal-03363623