Zobrazeno 1 - 10
of 447
pro vyhledávání: '"Aleksander S Popel"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is the third-leading cause of cancer-related death worldwide. Most patients with HCC are diagnosed at an advanced stage, and the median survival for patient
Externí odkaz:
https://doaj.org/article/9ff1d4b7764141d3a8e190936b947a24
Autor:
Alvaro Ruiz-Martinez, Chang Gong, Hanwen Wang, Richard J Sové, Haoyang Mi, Holly Kimko, Aleksander S Popel
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010254 (2022)
Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM) are powerful and efficient approaches for the analysis of biological systems and for clinical applications. Although QSP models are becoming essential in discovering
Externí odkaz:
https://doaj.org/article/177a5a968dcc43aab3f7c3fed92cda0a
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/46662a33a2a04b4e89ceddf01ba602a9
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background T cells have been recognized as core effectors for cancer immunotherapy. How to restore the anti-tumor ability of suppressed T cells or improve the lethality of cytotoxic T cells has become the main focus in immunotherapy. Bispecific antib
Externí odkaz:
https://doaj.org/article/15dcf4d1de2c4dd0a05588eca5148f72
Autor:
Chen Zhao, Adam C Mirando, Richard J Sové, Thalyta X Medeiros, Brian H Annex, Aleksander S Popel
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007468 (2019)
Macrophages respond to signals in the microenvironment by changing their functional phenotypes, a process known as polarization. Depending on the context, they acquire different patterns of transcriptional activation, cytokine expression and cellular
Externí odkaz:
https://doaj.org/article/5d56609b24fd4944b96a96ca96cfc190
Autor:
Hojjat Bazzazi, Aleksander S Popel
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005332 (2017)
Vascular endothelial growth factor (VEGF) is a powerful regulator of neovascularization. VEGF binding to its cognate receptor, VEGFR2, activates a number of signaling pathways including ERK1/2. Activation of ERK1/2 is experimentally shown to involve
Externí odkaz:
https://doaj.org/article/9d96c6031b06474987554fa222125eef
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005272 (2017)
Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of new blood vessels. Besides an increase in the production of pro-angiogenic signals such as vascular endothelial growth factor (VEGF), hypoxia also stimulat
Externí odkaz:
https://doaj.org/article/68634f2130c149499d8559558abf252f
Autor:
Chen Zhao, Aleksander S Popel
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004612 (2015)
HRMs (hypoxia-responsive miRNAs) are a specific group of microRNAs that are regulated by hypoxia. Recent studies revealed that several HRMs including let-7 family miRNAs were highly induced in response to HIF (hypoxia-inducible factor) stabilization
Externí odkaz:
https://doaj.org/article/f169461f11b8423c8ec24fe1a1c2b589
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110871 (2014)
Angiogenesis involves stimulation of endothelial cells (EC) by various cytokines and growth factors, but the signaling mechanisms are not completely understood. Combining dynamic gene expression time-course data for stimulated EC with protein-protein
Externí odkaz:
https://doaj.org/article/c8f9cbeeee264e51990350fc114acc9f
Autor:
Elena V Rosca, Marie-France Penet, Noriko Mori, Jacob E Koskimaki, Esak Lee, Niranjan B Pandey, Zaver M Bhujwalla, Aleksander S Popel
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111901 (2014)
We investigated the application of a mimetic 20 amino acid peptide derived from type IV collagen for treatment of breast cancer. We showed that the peptide induced a decrease of proliferation, adhesion, and migration of endothelial and tumor cells in
Externí odkaz:
https://doaj.org/article/1a4e8c7b38bc4547866445faf3996f0d