Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Aleksander D. Szymaniak"'
Autor:
Aleksander D Szymaniak, Rongjuan Mi, Shannon E McCarthy, Adam C Gower, Taylor L Reynolds, Michael Mingueneau, Maria Kukuruzinska, Xaralabos Varelas
Publikováno v:
eLife, Vol 6 (2017)
Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effecto
Externí odkaz:
https://doaj.org/article/d03c769aeff5471ca06c99db7e6a4e4a
Autor:
Finn Hawkins, Amalia Capilla, Aleksander D. Szymaniak, Alexander Stuffer, Marall Vedaie, Dar Heinze, Aditya Mithal, Carlos Villacorta-Martin, Gustavo Mostoslavsky, Darrell N. Kotton, Megan Peasley, Kristine M. Abo, John Mahoney, Anjali Jacob, Andrew Berical
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Efficient generation of human induced pluripotent stem cell (hiPSC)-derived human intestinal organoids (HIOs) would facilitate the development of in vitro models for a variety of diseases that affect the gastrointestinal tract, such as inflammatory b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb880bb2d5f5325460f600f2654102b
https://doi.org/10.1038/s41467-019-13916-6
https://doi.org/10.1038/s41467-019-13916-6
Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap
Publikováno v:
Developmental Cell. 34:283-296
SummaryEpithelial cells undergo dynamic polarity changes as organs pattern, but the relationship between epithelial polarity and cell fate is poorly understood. Using the developing lung as a model, we found that distinct alterations in apical-basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309875626af5625d1b4d269993caa46d
https://doi.org/10.1016/j.devcel.2015.06.020
https://doi.org/10.1016/j.devcel.2015.06.020
Autor:
Aleksander D. Szymaniak, Maria A. Kukuruzinska, Taylor L. Reynolds, Xaralabos Varelas, Adam C. Gower, Shannon E McCarthy, Rongjuan Mi, Michael Mingueneau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d798a38e81daaaa6878ac365b2175e2e
https://doi.org/10.7554/elife.23499.020
https://doi.org/10.7554/elife.23499.020
Autor:
Aleksander D. Szymaniak, Wellington V. Cardoso, Munemasa Mori, John E. Mahoney, Xaralabos Varelas
Publikováno v:
Developmental Cell. 30(2):137-150
SummaryHow epithelial progenitor cells integrate local signals to balance expansion with differentiation during organogenesis is still little understood. Here, we provide evidence that the Hippo pathway effector Yap is a key regulator of this process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9759017edf70fc30f46f50f46327de
Publikováno v:
Marine Biology. 160:1477-1488
The comparative analysis of genetic structure and phylogeography of marine species can reveal the relative importance of common biogeographic barriers and species-specific evolutionary histories. In the present study, mitochondrial COI sequences from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c57d16391c685e821b75abce965e0625
https://doi.org/10.1007/s00227-013-2201-0
https://doi.org/10.1007/s00227-013-2201-0
Autor:
Agnieszka P. Looney, Maria Trojanowska, T. Toyama, Xaralabos Varelas, Robert W. Simms, Lukasz Stawski, Paul Haines, Aleksander D. Szymaniak, Brendon M. Baker
Publikováno v:
The Journal of investigative dermatology. 138(1)
Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera; Biogen, Cambridge, MA), have shown therapeutic effects in several disease models, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede132465c6df478bdf907916b6d1609
https://pubmed.ncbi.nlm.nih.gov/28870693
https://pubmed.ncbi.nlm.nih.gov/28870693
Autor:
Maria R Stupnikov, Munemasa Mori, Jesus Paez-Cortez, James E. Schwob, Xaralabos Varelas, John E. Mahoney, Aleksander D. Szymaniak, Wellington V. Cardoso, Daniel B. Herrick, Hong Zhang
Basal cells are multipotent airway progenitors that generate distinct epithelial cell phenotypes crucial for homeostasis and repair of the conducting airways. Little is known about how these progenitor cells expand and transition to differentiation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68f72ecf3adfcd54c438fac1d515a48
https://europepmc.org/articles/PMC4302835/
https://europepmc.org/articles/PMC4302835/
Uncontrolled transforming growth factor-β (TGFβ) signaling promotes aggressive metastatic properties in late-stage breast cancers. However, how TGFβ-mediated cues are directed to induce tumorigenic events is poorly understood, particularly given t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee07fa4dffb028649c90786314587886
https://europepmc.org/articles/PMC4036353/
https://europepmc.org/articles/PMC4036353/