Výsledky vyhledávání - "Aleksander Bagaev"

Akademický článek

TIGIT is a key inhibitory checkpoint receptor in lymphoma

Autor: Yuanyuan Zha, Xiufen Chen, James Godfrey, Girish Venkataraman, Justin P Kline, Aleksander Bagaev, Jovian Yu, Nicole Sunseri, Alan Cooper, Arina Varlamova, Dmitry Zarubin, Yuriy Popov, Connor Jacobson, Ekaterina Postovalova, Zhongmin Xiang, Krystle Nomie, Sravya Tumuluru, Sonali M Smith

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)

Background PD-1 checkpoint blockade therapy (CBT) has greatly benefited patients with select solid tumors and lymphomas but has limited efficacy against diffuse large B-cell lymphoma (DLBCL). Because numerous inhibitory checkpoint receptors have been

Externí odkaz: https://doaj.org/article/4f9de0e70e7e43809db62f8d3b1fab29

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Akademický článek

Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)

Background Neoantigen (NeoAg) peptides displayed at the tumor cell surface by human leukocyte antigen molecules show exquisite tumor specificity and can elicit T cell mediated tumor rejection. However, few NeoAgs are predicted to be shared between pa

Externí odkaz: https://doaj.org/article/ac1fa606444a418b80b726080cf67799

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Abstract 6538: Development and refinement of functional gene expression signatures as a computational tool for comprehensive characterization of transcriptomic data

Autor: Elena Ocheredko, Nadezhda Lukashevich, Maria Savchenko, Sofia Kust, Syune Ambaryan, Dmitry Tabakov, Maria Sorokina, Linda Balabanian, Kushal Suryamohan, Anastasiya Zotova, Nathan Fowler, Aleksander Bagaev

Publikováno v: Cancer Research. 83:6538-6538

Functional gene expression signatures (FGES) are widely used as biomarkers in cancer diagnostics as descriptive and predictive models for treatment selection. Since FGES scores are based solely on gene expression profiles, they can be applied to data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a940c0c837e579d37ca742fe237c01e3
https://doi.org/10.1158/1538-7445.am2023-6538

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Abstract 5172: B cell content in the tumor microenvironment is associated with improved survival in stage II lung adenocarcinoma

Autor: Ivan Valiev, Nikita Kotlov, Anna Belozerova, Aleksandra Lopareva, Anna Butusova, Naira Samarina, Alexandra Boiko, Sandrine Degryse, Lecia Sequist, Mari Mino-Kenudson, Nathan Fowler, Aleksander Bagaev, Michael Lanuti, Ibiayi Dagogo-Jack

Publikováno v: Cancer Research. 82:5172-5172

In non-small cell lung cancer (NSCLC), likelihood of cure is heavily influenced by stage at diagnosis. In contrast to stage I where surgery achieves cure for >70% of patients, the majority of patients with stage II NSCLC will develop recurrent diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9242091e7cc49381512edc335e1a6c75
https://doi.org/10.1158/1538-7445.am2022-5172

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A clinical AI-driven multiplex immunofluorescence imaging pipeline to characterize tumor microenvironment heterogeneity

Autor: Dmitry Zarubin, Valeriy Belotskiy, Zhongmin Xiang, Arina Varlamova, Pavel Ovcharov, Ilia Galkin, Margarita Polyakova, Viktor Svekolkin, Grigory Perelman, Maria Bruttan, Jessica H. Brown, Ekaterina Postovalova, Aleksander Bagaev, Nathan Fowler

Publikováno v: Journal of Clinical Oncology. 40:3020-3020

3020 Background: Understanding the underlying heterogeneity of the tumor microenvironment (TME) on a single-cell level is becoming increasingly important to predict a patient’s response to immunotherapy. Conventional imaging methods can help reveal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e5f95db5e93e81228a95081017079f1
https://doi.org/10.1200/jco.2022.40.16_suppl.3020

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Reconstructing the tumor microenvironment to unlock therapeutic options in pancreatic cancer

Autor: Ben George, Samih Thalji, Subramaniam Malarkannan, Olga Kudryashova, Andrey Kravets, Mariia Gusakova, Dmitry Kravchenko, Dmitry Tychinin, Felix Frenkel, Aleksander Bagaev, Nara Shin, Maahum Mehdi, Mandana Kamgar, William A. Hall, Beth Erickson, Kathleen K. Christians, Douglas B. Evans, Susan Tsai

Publikováno v: Journal of Clinical Oncology. 40:589-589

589 Background: Spatiotemporal heterogeneity, paucity of actionable targets, and complexity of the tumor microenvironment (TME) are major barriers to therapeutic advances in pancreatic ductal adenocarcinoma (PDAC). We reconstructed the transcriptomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::524c119bfa25c163c4d1169d4934f19f
https://doi.org/10.1200/jco.2022.40.4_suppl.589

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Abstract 2011: HER2 expression and M2-like tumor infiltrating macrophages associated with Cabazitaxel activity in gastric cancer

Autor: Prashant K. Thakkar, Meredith E. Pittman, Olga Plotnikova, Chao Zhang, Yao Lu, Heinz Joseph Lenz, Nikita Kotlov, Bhavneet Bhinder, Allyson J. Ocean, Peter C. Enzinger, Sandipto Sarkar, Feliz Frenkel, Doron Betel, Olivier Elemento, Paraskevi Giannakakou, Manish A. Shah, Aleksander Bagaev, Andrew H. Ko

Publikováno v: Cancer Research. 80:2011-2011

Gastric cancer (GC), responsible for ~700,000 deaths worldwide annually, is a dismal disease, with median survival for metastatic disease less than 1 year. We examined the efficacy and safety of cabazitaxel, a novel 3rd generation taxane, in the 2nd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6858c35fca8e837ed75c5ce1a8a2ae95
https://doi.org/10.1158/1538-7445.am2020-2011

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