Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Alejo Efeyan"'
Autor:
Andrés Pastor‐Fernández, Manuel Montero Gómez de las Heras, Jose Ignacio Escrig‐Larena, Marta Barradas, Cristina Pantoja, Adrian Plaza, Jose Luis Lopez‐Aceituno, Esther Durán, Alejo Efeyan, Maria Mittelbrunn, Lola Martinez, Pablo Jose Fernandez‐Marcos
Publikováno v:
Cancer Communications, Vol 44, Iss 4, Pp 508-513 (2024)
Externí odkaz:
https://doaj.org/article/d981460a5ab5414c9b471f55c6f0e1bc
Autor:
Ana Belén Plata-Gómez, Lucía de Prado-Rivas, Alba Sanz, Nerea Deleyto-Seldas, Fernando García, Celia de la Calle Arregui, Camila Silva, Eduardo Caleiras, Osvaldo Graña-Castro, Elena Piñeiro-Yáñez, Joseph Krebs, Luis Leiva-Vega, Javier Muñoz, Ajay Jain, Guadalupe Sabio, Alejo Efeyan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The metabolic functions of the liver are spatially organized in a phenomenon called zonation, linked to the differential exposure of portal and central hepatocytes to nutrient-rich blood. The mTORC1 signaling pathway controls cellular metabo
Externí odkaz:
https://doaj.org/article/4772ae75e9d74a97a90d1058448dea3e
Autor:
Alberto Hernández-Barranco, Vanesa Santos, Marina S. Mazariegos, Eduardo Caleiras, Laura Nogués, Frédéric Mourcin, Simon Léonard, Christelle Oblet, Steve Genebrier, Delphine Rossille, Alberto Benguría, Alba Sanz, Enrique Vázquez, Ana Dopazo, Alejo Efeyan, Ana Ortega-Molina, Michel Cogne, Karin Tarte, Héctor Peinado
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113705- (2024)
Summary: Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined. Here, we study the effect of Ngfr loss on lymph node organization and function, dem
Externí odkaz:
https://doaj.org/article/633cda8ce4e244e3af309d6246a7a4de
Autor:
Lara P. Fernández, Nerea Deleyto-Seldas, Gonzalo Colmenarejo, Alba Sanz, Sonia Wagner, Ana Belén Plata-Gómez, Mónica Gómez-Patiño, Susana Molina, Isabel Espinosa-Salinas, Elena Aguilar-Aguilar, Sagrario Ortega, Osvaldo Graña-Castro, Viviana Loria-Kohen, Pablo J. Fernández-Marcos, Alejo Efeyan, Ana Ramírez de Molina
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Background Overweight and obesity are defined by an anomalous or excessive fat accumulation that may compromise health. To find single-nucleotide polymorphisms (SNPs) influencing metabolic phenotypes associated with the obesity state, we ana
Externí odkaz:
https://doaj.org/article/dc6c2ac9e5b941d99a8e6e99afe95335
Autor:
Marta Barradas, Adrián Plaza, Gonzalo Colmenarejo, Iolanda Lázaro, Luis Filipe Costa-Machado, Roberto Martín-Hernández, Victor Micó, José Luis López-Aceituno, Jesús Herranz, Cristina Pantoja, Hector Tejero, Alberto Diaz-Ruiz, Fatima Al-Shahrour, Lidia Daimiel, Viviana Loria-Kohen, Ana Ramirez de Molina, Alejo Efeyan, Manuel Serrano, Oscar J. Pozo, Aleix Sala-Vila, Pablo J. Fernandez-Marcos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Fasting has been reported to protect from chemotherapy-associated toxicity. Here, the authors show that fatty acid profiles in erythrocyte membranes and gene expression from peripheral blood mononuclear cells are associated to the fasting-mediated be
Externí odkaz:
https://doaj.org/article/7ea8ae6de1c54a5f94fab1361ab31858
Autor:
Yurena Vivas-García, Alejo Efeyan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extrem
Externí odkaz:
https://doaj.org/article/98f47212bd9b4130ba2efa0fbbe14ab1
Autor:
Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and sh
Externí odkaz:
https://doaj.org/article/ede1c5d31c18497daed3a08d29f4a91b
Autor:
Caroline A. Lamb1, Victoria Fabris1, Mara Alicia Gorostiaga1, Luisa A. Helguero1, Alejo Efeyan1, Mara Cecilia Bottino1, Marina Simian1, Roco Soldati1, Norberto Sanjuan1, Alfredo Molinolo1, Claudia Lanari1
Publikováno v:
Journal of Cellular Physiology. Mar2005, Vol. 202 Issue 3, p672-682. 11p.
Autor:
Ana Belén Plata-Gómez, María Crespo, Celia de la Calle Arregui, Lucía de Prado-Rivas, Guadalupe Sabio, Alejo Efeyan
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100918- (2021)
Summary: We present a protocol for measuring the activity of the mechanistic target of rapamycin (mTOR) pathway in ex vivo isolated mouse primary hepatocytes. It can be used as a tool for genetic, pharmacological, metabolomic, and signal transduction
Externí odkaz:
https://doaj.org/article/010ed5de323c447baeb227d6d8876871
Autor:
Ana Ortega-Molina, Alejo Efeyan
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 5 (2021)
The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mouse genetic
Externí odkaz:
https://doaj.org/article/7b4946ff2e804c2e885e8aba35ccab7a