Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alejo A Morales"'
Autor:
Jacqueline F. Machi, Isabella Altilio, Yue Qi, Alejo A. Morales, Diego H. Silvestre, Diana R. Hernandez, Nicolas Da Costa-Santos, Aline G. Santana, Mehrnoosh Neghabi, Parisa Nategh, Thiago L. Castro, João P. Werneck-de-Castro, Mahsa Ranji, Fabiana S. Evangelista, Roberto I. Vazquez-Padron, Ernesto Bernal-Mizrachi, Claudia O. Rodrigues
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardiovascular disease. Endothelial dysfunction is an early predictor of obesity. However, little is known regarding how early endoth
Externí odkaz:
https://doaj.org/article/70b92df7ee8c4458b29ae8f173c4258e
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52662 (2012)
Arsenic trioxide (ATO) has been tested in relapsed/refractory multiple myeloma with limited success. In order to better understand drug mechanism and resistance pathways in myeloma we generated an ATO-resistant cell line, 8226/S-ATOR05, with an IC50
Externí odkaz:
https://doaj.org/article/4fa433d622014801bf8364aec04ac7da
Autor:
April W. Tan, Xiaoying Tong, Silvia Alvarez-Cubela, Pingping Chen, Aline Guimarães Santana, Alejo A. Morales, Runxia Tian, Rae Infante, Vanessa Nunes de Paiva, Shathiyah Kulandavelu, Merline Benny, Juan Dominguez-Bendala, Shu Wu, Karen C. Young, Claudia O. Rodrigues, Augusto F. Schmidt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Background: Intra-amniotic inflammation (IAI) is associated with increased risk of preterm birth and bronchopulmonary dysplasia (BPD), but the mechanisms by which IAI leads to preterm birth and BPD are poorly understood, and there are no effective th
Externí odkaz:
https://doaj.org/article/c3673c1112084506864b0db5ed712490
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1241 (2022)
Multiple Sclerosis (MS) is a chronic CNS autoimmune disease characterized by immune-mediated demyelination, axon loss, and disability. Dysregulation of transglutaminase-2 (TG2) has been implicated in disease initiation and progression. Herein, TG2 ex
Externí odkaz:
https://doaj.org/article/08e5e3b7c8c34aa29819d7cd7af226ca
Autor:
Yue Qi, Mirza M. F. Qadir, Araceli A. Hastreiter, Ricardo A. Fock, Jacqueline F. Machi, Alejo A. Morales, Ying Wang, Zhipeng Meng, Claudia O. Rodrigues
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Endothelial cells play an essential role in inflammation through synthesis and secretion of chemoattractant cytokines and expression of adhesion molecules required for inflammatory cell attachment and infiltration. The mechanisms by which endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cfe7f0862c9067e7a8d75357d6c193
Autor:
Augusto F. Schmidt, Yue Qi, Jacqueline Freire Machi, Claudia O. Rodrigues, Nikole Q Mendez, Alejo A. Morales
Publikováno v:
Circulation Research. 129
Cardiotoxicity is the most common complication in patients undergoing chemotherapy, and the leading cause of death in long-term cancer survivors. Anthracyclines are highly effective drugs broadly used in cancer treatment, but with limited use due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9303d25aaf1073d7e30d49d05133fa
https://doi.org/10.1161/res.129.suppl_1.p399
https://doi.org/10.1161/res.129.suppl_1.p399
Autor:
Urs Rutishauser, Mousumi Ghosh, Damien D. Pearse, Sudheendra N.R. Rao, Alejo A. Morales, Abderrahman El-Maarouf, Warren W. Wakarchuk
Publikováno v:
Neuroscience letters. 748
Polysialic acid (PolySia) is a critical post-translational modification on the neural cell adhesion molecule (NCAM, a.k.a., CD56), important for cell migration and axon growth during nervous system development, plasticity and repair. PolySia inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c47978e39a7f9a0e4a851208a1bca7
https://pubmed.ncbi.nlm.nih.gov/33540059
https://pubmed.ncbi.nlm.nih.gov/33540059
Autor:
Shannon M. Matulis, Jonathan L. Kaufman, Jiangxia Liu, Lawrence H. Boise, Kelvin P. Lee, David Siefker, Sagar Lonial, Delia Gutman, Metin Kurtoglu, Alejo A. Morales
Publikováno v:
Blood. 118:1329-1339
Dependence on Bcl-2 proteins is a common feature of cancer cells and provides a therapeutic opportunity. ABT-737 is an antagonist of antiapoptotic Bcl-2 proteins and therefore is a good predictor of Bcl-xL/Bcl-2 dependence. Surprisingly, analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef2299eccef2be176c52cea8c085e69
https://doi.org/10.1182/blood-2011-01-327197
https://doi.org/10.1182/blood-2011-01-327197
Autor:
Neelima Sukumar, Robert S. Kirsner, Lesley R. de Armas, Gregory V. Plano, Mathias G. Lichtenheld, George P. Munson, Motoaki Shiratsuchi, Kirill A. Lyapichev, Ryan McCormack, Olivera Stojadinovic, Louis Gonzalez, Natasa Strbo, David G. Russell, Melissa L Olsson, Eckhard R. Podack, Marjana Tomic-Canic, Desiree G Fiorentino, Alejo A. Morales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef330a92586c90545e6dc86edd961f03
https://doi.org/10.7554/elife.06508.037
https://doi.org/10.7554/elife.06508.037
Autor:
Gregory V. Plano, Eckhard R. Podack, Motoaki Shiratsuchi, Melissa L Olsson, Alejo A. Morales, Robert S. Kirsner, Kirill A. Lyapichev, Natasa Strbo, Lesley R. de Armas, Mathias G. Lichtenheld, Desiree G Fiorentino, Neelima Sukumar, Marjana Tomic-Canic, David G. Russell, Olivera Stojadinovic, Louis Gonzalez, Ryan McCormack, George P. Munson
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663f96bc810799c32bb7f3d4123ce3b1
https://elifesciences.org/articles/06508
https://elifesciences.org/articles/06508