Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alejandro Velikovsky"'
Publikováno v:
Annual Review of Biophysics. 42:191-215
The adaptive immune system, which is based on highly diverse antigen receptors that are generated by somatic recombination, arose approximately 500 Mya at the dawn of vertebrate evolution. In jawed vertebrates, adaptive immunity is mediated by antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74eaff96d58fbbc0fdc7b50ba0b3ae88
https://doi.org/10.1146/annurev-biophys-083012-130422
https://doi.org/10.1146/annurev-biophys-083012-130422
Autor:
S. Annie Gai, Roy A. Mariuzza, K. Dane Wittrup, Zeev Pancer, Gang Xu, C. Alejandro Velikovsky, Satoshi Tasumi, Martin F. Flajnik
Publikováno v:
Proceedings of the National Academy of Sciences. 106:12891-12896
Lamprey are members of the ancestral vertebrate taxon (jawless fish), which evolved rearranging antigen receptors convergently with the jawed vertebrates. But instead of Ig superfamily domains, lamprey variable lymphocyte receptors (VLRs) consist of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f503536eb0abe5e3aa58d393cd279438
https://doi.org/10.1073/pnas.0904443106
https://doi.org/10.1073/pnas.0904443106
Autor:
Roy A. Mariuzza, Lu Deng, Marisa M. Fernández, Lukasz K. Chlewicki, C. Alejandro Velikovsky, Vinay Kumar
Publikováno v:
Immunity. 27(4):572-584
SummaryNatural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cad180a25e019084d60fbd4a52ae9b
Autor:
Irene Nepomnaschy, Silvia Revelli, Isabel Piazzon, Eduardo Roggero, Alejandro Velikovsky, Oscar Bottasso, Ana María Cánovas Pérez
Publikováno v:
FEMS Immunology & Medical Microbiology. 41:123-131
Infection with Trypanosoma cruzi in C57BL/6 mice leads to a progressive fatal disease accompanied by thymocyte depletion, which is not related with a higher parasite burden but with increased serum levels of tumour necrosis factor alpha (TNF- alpha).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbff507529663bb10792b83123e2b9f
https://doi.org/10.1016/j.femsim.2004.02.003
https://doi.org/10.1016/j.femsim.2004.02.003
Autor:
Lawrence E. Samelson, Roy A. Mariuzza, Chittoor P. Swaminathan, C. Alejandro Velikovsky, Sangwoo Cho, Jon C. D. Houtman
Publikováno v:
The EMBO Journal. 23:1441-1451
The transmembrane protein, linker for activation of T cells (LAT), is essential for T-cell activation and development. Phosphorylation of LAT at multiple tyrosines creates binding sites for the adaptors Gads and Grb2, leading to nucleation of multipr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5deebb5e340567e48c7e90758c2997a
https://doi.org/10.1038/sj.emboj.7600168
https://doi.org/10.1038/sj.emboj.7600168
Autor:
Fernando A. Goldbaum, Ana Cauerhff, C. Alejandro Velikovsky, Andrea S. Llera, Marie-Madeleine Riottot, Roberto J. Poljak
Publikováno v:
The Journal of Immunology. 162:6040-6045
The affinities (Ka) and association rate constants (kon) of 23 mouse (BALB/c) anti-lysozyme mAbs obtained after short and prolonged immunizations have been measured by plasmon resonance techniques. The affinities for the 23 Abs, measured using their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79b3b8d8e7a9f4fc339de24458eb4b17
https://doi.org/10.4049/jimmunol.162.10.6040
https://doi.org/10.4049/jimmunol.162.10.6040
Autor:
Roy A. Mariuzza, John P. Marino, Susan Krueger, Daniel R. Scott, C. Alejandro Velikovsky, Hirsh Nanda
Publikováno v:
Biophysical Journal. 106(2)
Mainstream approaches to examining the biophysical properties of integral membrane proteins (IMPs) possess severe limitations, mostly as a consequence of the instability of IMPs in solution. As a result, it has become common practice to characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9addd8237d0735196c394bae704cf5c7
Autor:
Jeffrey C. Gildersleeve, Zeev Pancer, Maqbool A. Siddiqui, Roy A. Mariuzza, C. Alejandro Velikovsky, Ming Luo, Xia Hong, Joseph J. Barchi, Xinbo Yang
Publikováno v:
The Journal of biological chemistry. 288(32)
Variable lymphocyte receptors (VLRs) are leucine-rich repeat proteins that mediate adaptive immunity in jawless vertebrates. VLRs were recently shown to recognize glycans, such as the tumor-associated Thomsen-Friedenreich antigen (TFα; Galβ1–3Gal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd54e1f438a861fa79fc20ce7155dd15
https://pubmed.ncbi.nlm.nih.gov/23782692
https://pubmed.ncbi.nlm.nih.gov/23782692
Autor:
Lu Deng, L. Aravind, Lakshminarayan M. Iyer, Gang Xu, Satoshi Tasumi, Martin F. Flajnik, C. Alejandro Velikovsky, Roy A. Mariuzza, Zeev Pancer, Melissa C. Kerzic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(30)
Adaptive immunity in jawless vertebrates is mediated by leucine-rich repeat proteins called "variable lymphocyte receptors" (VLRs). Two types of VLR (A and B) are expressed by mutually exclusive lymphocyte populations in lamprey. VLRB lymphocytes res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e94135106719631c742bbb6a51358ea
https://pubmed.ncbi.nlm.nih.gov/20616002
https://pubmed.ncbi.nlm.nih.gov/20616002
Publikováno v:
Biological Chemistry. 391
Adaptive immunity in jawless vertebrates is mediated by antigen receptors that are fundamentally different from those of jawed vertebrates. Whereas antibodies and T cell receptors (TCRs) are composed of immunoglobulin (Ig) domains, the variable lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3deaacd1cb30edb09c5d998525af2bb2
https://doi.org/10.1515/bc.2010.091
https://doi.org/10.1515/bc.2010.091