Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Alejandro Soto‐Gutierrez"'
Autor:
Zehra N. Kocas-Kilicarslan, Zeliha Cetin, Lanuza A.P. Faccioli, Takashi Motomura, Sriram Amirneni, Ricardo Diaz-Aragon, Rodrigo M. Florentino, Yiyue Sun, Iris Pla-Palacin, Mengying Xia, Mark T. Miedel, Takeshi Kurihara, Zhiping Hu, Alina Ostrowska, Zi Wang, Robert Constantine, Albert Li, D. Lansing Taylor, Jaideep Behari, Alejandro Soto-Gutierrez, Edgar N. Tafaleng
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 1, Pp 67-77 (2024)
Background and Aims: Chronic liver injury that results in cirrhosis and end-stage liver disease (ESLD) causes more than 1 million deaths annually worldwide. Although the impact of genetic factors on the severity of metabolic dysfunction-associated st
Externí odkaz:
https://doaj.org/article/a352c00a654e49048cd6eb2ec5a1d2e4
Autor:
Silvia Liu, Yan-Ping Yu, Bao-Guo Ren, Tuval Ben-Yehezkel, Caroline Obert, Mat Smith, Wenjia Wang, Alina Ostrowska, Alejandro Soto-Gutierrez, Jian-Hua Luo
Publikováno v:
eLife, Vol 12 (2024)
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. Genetic mutation is essential in species evolution and cancer development. Accurate long-read transcriptome sequencing at single-cell level is required to deciph
Externí odkaz:
https://doaj.org/article/23e99210857f4a04b3e00be99733567f
Autor:
Kimberly Ortiz, Zeliha Cetin, Yiyue Sun, Zhiping Hu, Takeshi Kurihara, Edgar N. Tafaleng, Rodrigo M. Florentino, Alina Ostrowska, Alejandro Soto-Gutierrez, Lanuza A.P. Faccioli
Publikováno v:
Organogenesis, Vol 19, Iss 1 (2023)
ABSTRACTPrimary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), the most common types of cholestatic liver disease (CLD), result in enterohepatic obstruction, bile acid accumulation, and hepatotoxicity. The mechanisms by which hep
Externí odkaz:
https://doaj.org/article/474ad1eb458e4832bae349ddc7a20857
Autor:
Rodrigo M. Florentino, Qin Li, Michael C. Coard, Nils Haep, Takashi Motomura, Ricardo Diaz‐Aragon, Lanuza A. P. Faccioli, Sriram Amirneni, Zehra N. Kocas‐Kilicarslan, Alina Ostrowska, James E. Squires, Andrew P. Feranchak, Alejandro Soto‐Gutierrez
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1561-1573 (2022)
Abstract The initial creation of human‐induced pluripotent stem cells (iPSCs) set the foundation for the future of regenerative medicine. Human iPSCs can be differentiated into a variety of cell types in order to study normal and pathological molec
Externí odkaz:
https://doaj.org/article/70dc40a2ee5040eebed9cfab76e9f4ff
Autor:
Lanuza A. P. Faccioli, Zeliha Cetin, Zehra N. Kocas-Kilicarslan, Kimberly Ortiz, Yiyue Sun, Zhiping Hu, Takeshi Kurihara, Edgar N. Tafaleng, Rodrigo M. Florentino, Zi Wang, Mengying Xia, Mark T. Miedel, D. Lansing Taylor, Jaideep Behari, Alina Ostrowska, Robert Constantine, Albert Li, Alejandro Soto-Gutierrez
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13406 (2023)
Metabolic-dysfunction-associated steatotic liver disease (MASLD), which affects 30 million people in the US and is anticipated to reach over 100 million by 2030, places a significant financial strain on the healthcare system. There is presently no FD
Externí odkaz:
https://doaj.org/article/8471cbb831af478fb2c14395e536252e
Autor:
Edgar N. Tafaleng, Amitava Mukherjee, Aaron Bell, Kazutoyo Morita, Jorge Guzman‐Lepe, Nils Haep, Rodrigo M. Florentino, Ricardo Diaz‐Aragon, Carla Frau, Alina Ostrowska, Joshua R. Schultz, Paolo G. V. Martini, Alejandro Soto‐Gutierrez, Ira J. Fox
Publikováno v:
Hepatology Communications, Vol 5, Iss 11, Pp 1911-1926 (2021)
The only definitive therapy for end‐stage liver disease is whole‐organ transplantation. The success of this intervention is severely limited by the complexity of the surgery, the cost of patient care, the need for long‐term immunosuppression, a
Externí odkaz:
https://doaj.org/article/eefaa6013f164a9e83b52ff3fa2c4cc8
Autor:
Rodrigo M. Florentino, Kazutoyo Morita, Nils Haep, Takashi Motomura, Ricardo Diaz-Aragon, Lanuza A.P. Faccioli, Alexandra Collin de l’Hortet, Zeliha Cetin, Carla Frau, Lawrence Vernetti, Anna-Klara Amler, Alexander Thomas, Tobias Lam, Lutz Kloke, Kazuki Takeishi, D. Lansing Taylor, Ira J. Fox, Alejandro Soto-Gutierrez
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105503- (2022)
Summary: Advances in cellular engineering, as well as gene, and cell therapy, may be used to produce human tissues with programmable genetically enhanced functions designed to model and/or treat specific diseases. Fabrication of synthetic human liver
Externí odkaz:
https://doaj.org/article/456852f3c07c4362a0ae4b0b01b19d89
Autor:
Ranjeet S. Kalsi, Alina Ostrowska, Adam Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva, Jen Symmonds, Alejandro Soto-Gutierrez, John J. Crowley, Miguel Reyes-Mugica, Giselle Sanchez-Guerrero, Hartmut Jaeschke, Bruce P. Amiot, Marilia Cascalho, Scott L. Nyberg, Jeffrey L. Platt, Edgar N. Tafaleng, Ira J. Fox
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when t
Externí odkaz:
https://doaj.org/article/4a6dde84b6564e42889da8c6dbe04394
Autor:
Sojin Lee, Taofeek O. Usman, Jun Yamauchi, Goma Chhetri, Xingchun Wang, Gina M. Coudriet, Cuiling Zhu, Jingyang Gao, Riley McConnell, Kyler Krantz, Dhivyaa Rajasundaram, Sucha Singh, Jon Piganelli, Alina Ostrowska, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Aatur D. Singhi, Radhika Muzumdar, Allan Tsung, H. Henry Dong
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Hepatic inflammation is culpable for the evolution of asymptomatic steatosis to nonalcoholic steatohepatitis (NASH). Hepatic inflammation results from abnormal macrophage activation. We found that FoxO1 links overnutrition to hepatic inflammation by
Externí odkaz:
https://doaj.org/article/2b970c28217f4f17825383167b76ab08
Autor:
Rodrigo M. Florentino, Nicolas A. Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman‐Lepe, Edgar N. Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Paranjpe, George K. Michalopoulos, Aaron Bell, Deepak Nagrath, Sarah J. Hainer, Ira J. Fox, Alejandro Soto‐Gutierrez
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients wit
Externí odkaz:
https://doaj.org/article/a366b3ff63454cfe85adee4824c052ae