Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alejandro Sosa-Peinado"'
Autor:
Alejandro Sosa-Peinado, Karina Fructuoso-García, L. X. Vásquez-Bochm, Martin González-Andrade
Publikováno v:
Molecules, Vol 27, Iss 21, p 7161 (2022)
In the present study, we reported the interactions at the molecular level of a series of compounds called Bisindolylmaleimide, as potential inhibitors of the calmodulin protein. Bisindolylmaleimide compounds are drug prototypes derived from Staurospo
Externí odkaz:
https://doaj.org/article/db8fc7bf4dd844b49828b720e16b8218
Autor:
L. X. Vásquez-Bochm, Isabel Velázquez-López, Rachel Mata, Alejandro Sosa-Peinado, Patricia Cano-Sánchez, Martin González-Andrade
Publikováno v:
Chemosensors, Vol 9, Iss 9, p 250 (2021)
Here, we show the utility of the fluorescent biosensor hCaM-M124C-mBBr in detecting and determining the affinity of serotonin (5-HT). We obtained a Kd of 5-HT (0.71 μm) for the first time, the same order of magnitude as most anti-CaM drugs. This dat
Externí odkaz:
https://doaj.org/article/7948a4b6271c4fb994e2f403d14def64
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 5, p e1002054 (2011)
Molecular recognition is determined by the structure and dynamics of both a protein and its ligand, but it is difficult to directly assess the role of each of these players. In this study, we use Markov State Models (MSMs) built from atomistic simula
Externí odkaz:
https://doaj.org/article/e02c0f6603d448b488d28d217326a5fc
Autor:
Renan Vergara, Tania Berrocal, Eva Isela Juárez Mejía, Sergio Romero-Romero, Isabel Velázquez-López, Nancy O. Pulido, Haven A. López Sanchez, Daniel-Adriano Silva, Miguel Costas, Adela Rodríguez-Romero, Rogelio Rodríguez-Sotres, Alejandro Sosa-Peinado, D. Alejandro Fernández-Velasco
Publikováno v:
The FEBS Journal.
Substrate-binding proteins (SBP) are used by organisms from the three domains of life for transport and signaling. SBPs are composed of two domains that collectively trap ligands with high affinity and selectivity. To explore the role of the domains
Autor:
Martin Gonzalez‐Andrade, L. X. Vásquez-Bochm, Patricia Cano-Sánchez, Isabel Velázquez-López, R Mata, Alejandro Sosa-Peinado
Publikováno v:
Chemosensors, Vol 9, Iss 250, p 250 (2021)
Chemosensors; Volume 9; Issue 9; Pages: 250
Chemosensors; Volume 9; Issue 9; Pages: 250
Here, we show the utility of the fluorescent biosensor hCaM-M124C-mBBr in detecting and determining the affinity of serotonin (5-HT). We obtained a Kd of 5-HT (0.71 μm) for the first time, the same order of magnitude as most anti-CaM drugs. This dat
Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents
Autor:
Alejandro Sosa-Peinado, Erika León-Cruz, Patricia Cano-Sánchez, Isabel Velázquez-López, Deyamira Matuz-Mares, Martín González-Andrade
We study the CaM-peptide interactions for four CaM-related peptides with different calcium equivalents, using the hCaM-M124C-mBBr biosensor and Molecular Dynamics (MD). Due to the high sensitivity of the biosensor, we were able to calculate five Kds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668faf603caed081bc16e234b3cadc62
Autor:
Alejandro Sosa-Peinado, Birte Höcker, Sooruban Shanmugaratnam, Alfredo Torres-Larios, Rogelio Rodríguez-Sotres, Jesús Banda-Vázquez
Publikováno v:
Protein Science. 27:957-968
Computational protein design is still a challenge for advancing structure-function relationships. While recent advances in this field are promising, more information for genuine predictions is needed. Here, we discuss different approaches applied to
Autor:
Sergio Trejo-Estrada, Alejandro Sosa-Peinado, Edgar Arturo Téllez-Espino, Miguel Ángel Plascencia-Espinosa, María Eugenia Hidalgo-Lara, Carla De La Cerna-Hernández
Publikováno v:
American Journal of Biochemistry and Biotechnology. 13:157-166
The thermotolerant strain Brevibacillus thermoruber 9X-GLC produces large amounts of β-D-glucosidase and cellobiohydrolase when grown on cellobiose and avicel. 9X-GLC was isolated from hot compost of sugarcane bagasse and filter mud and selected for
Autor:
Adela Rodríguez-Romero, Isabel Velázquez-López, Alejandro Sosa-Peinado, Nancy O. Pulido, Georgina Espinoza‐Pérez, Sergio Romero-Romero, Annia Rodríguez-Hernández, Renan Vergara, Daniel A. Fernández-Velasco
Publikováno v:
The FEBS journalReferences. 287(4)
The study of binding thermodynamics is essential to understand how affinity and selectivity are acquired in molecular complexes. Periplasmic binding proteins (PBPs) are macromolecules of biotechnological interest that bind a broad number of ligands a
Autor:
Cristina Salinas-Nolasco, Ivette Martínez-Vieyra, Edgar Oliver López-Villegas, Doris Cerecedo, Alejandro Sosa-Peinado, Araceli Evangelina Chávez-Piña, Erika Reus-Chavarría, J.V. Méndez-Méndez
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1861(2)
Hypertension (HTN), i.e. abnormally high blood pressure, is a major risk factor for heart attack, stroke, and kidney failure. The Epithelial Sodium Channel (ENaC), one of the main transporters regulates blood pressure by tightly controlling the sodiu