Výsledky vyhledávání - "Alejandro Sevilleja-Ortiz"

Akademický článek

Functional Role of STIM-1 and Orai1 in Human Microvascular Aging

Autor: Mariam El Assar, Esther García-Rojo, Alejandro Sevilleja-Ortiz, Alberto Sánchez-Ferrer, Argentina Fernández, Borja García-Gómez, Javier Romero-Otero, Leocadio Rodríguez-Mañas, Javier Angulo

Publikováno v: Cells, Vol 11, Iss 22, p 3675 (2022)

The impact of aging on vascular function is heterogeneous depending on the vascular territories. Calcium regulation plays a key role in vascular function and has been implicated in aging-related hypercontractility of corpus cavernosum. We aimed to ev

Externí odkaz: https://doaj.org/article/c41b778ede8c46e59456f8f3619e73ef

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Akademický článek

Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats

Autor: Claudia Balderas, Javier Angulo, Alejandro Sevilleja-Ortiz, Concepción Peiró, Susana Vallejo, Pilar Dongil, Begoña de Ancos, Concepción Sánchez-Moreno

Publikováno v: Antioxidants, Vol 11, Iss 10, p 1953 (2022)

The objective of this study was to investigate the effects of onion and apple functional ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard diet [obese control (OC) group], standard diet containing 10% onion [

Externí odkaz: https://doaj.org/article/033a4dd1d70c4c72ae3e718b0a78d218

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Akademický článek

Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention

Autor: Javier Angulo, Mariam El Assar, Alejandro Sevilleja-Ortiz, Argentina Fernández, Alberto Sánchez-Ferrer, Javier Romero-Otero, Juan I. Martínez-Salamanca, José M. La Fuente, Leocadio Rodríguez-Mañas

Publikováno v: Redox Biology, Vol 26, Iss , Pp - (2019)

Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease development. Ageing-related vascular dysfunction involves defective antioxidant response. Nuclear factor erythroid 2-like-2 (Nrf2), orchestrates cellular re

Externí odkaz: https://doaj.org/article/d1ba8369e2f747f6be898f70ad3bca49

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STIM/Orai Inhibition as a Strategy for Alleviating Diabetic Erectile Dysfunction Through Modulation of Rat and Human Penile Tissue Contractility and in vivo Potentiation of Erectile Responses

Autor: Alejandro Sevilleja-Ortiz, Mariam El Assar, Borja García-Gómez, José M. La Fuente, Manuel Alonso-Isa, Javier Romero-Otero, Juan I. Martínez-Salamanca, Argentina Fernández, Leocadio Rodríguez-Mañas, Javier Angulo

Publikováno v: The Journal of Sexual Medicine. 19:1733-1749

Background Stromal interaction molecule (STIM)/Orai calcium entry system appears to have a role in erectile dysfunction (ED) pathophysiology but its specific contribution to diabetic ED was not elucidated. Aim To evaluate STIM/Orai inhibition on func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdfa023710d0529f74f3ecc868648ca
https://doi.org/10.1016/j.jsxm.2022.08.200

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Enhanced Contribution of Orai Channels to Contractility of Human Penile Smooth Muscle in Erectile Dysfunction

Autor: José M. La Fuente, Javier Angulo, E. García-Rojo, Borja García-Gómez, José Medina-Polo, Mariam El Assar, Argentina Fernández, Leocadio Rodríguez-Mañas, Alejandro Sevilleja-Ortiz, Javier Romero-Otero

Publikováno v: The Journal of Sexual Medicine. 17:881-891

Background Store-operated calcium entry and its key players, stromal interaction molecule (STIM) and Orai calcium channels, have been proposed as emergent therapeutic targets in cardiovascular pathophysiology. We hypothesize alteration of STIM/Orai s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd54f786e4deef325dab8af71c77976e
https://doi.org/10.1016/j.jsxm.2020.02.020

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Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue

Autor: José M. La Fuente, Alberto Sánchez-Ferrer, Leocadio Rodríguez-Mañas, Borja García-Gómez, Argentina Fernández, Mariam El Assar, E. García-Rojo, Alejandro Sevilleja-Ortiz, Javier Romero-Otero, Javier C. Angulo

Publikováno v: Mechanisms of ageing and development. 200

The role of STIM/Orai calcium entry system on vascular ageing has not been elucidated. We aimed to evaluate the influence of ageing on STIM/Orai signalling and its role on ageing-induced alterations of contractile function in rat corpus cavernosum (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78aa49c36255c88ed8a3e27eb97ccd2
https://pubmed.ncbi.nlm.nih.gov/34699858

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MP84-09 DEFECTIVE L-CYSTEINE/HYDROGEN SULFIDE PATHWAY IN HUMAN CORPUS CAVERNOSUM AND PENILE ARTERIES FROM MEN WITH ERECTILE DYSFUNCTION

Autor: Alejandro Sevilleja-Ortiz, José M. La Fuente, Juan Ignacio Martínez-Salamanca, Javier C. Angulo, Joaquín Carballido, Esaú Fernández-Pascual

Publikováno v: Journal of Urology. 203

INTRODUCTION AND OBJECTIVE:Hydrogen sulfide (H2S) signaling has been proposed to participate in erectile physiology. L-cysteine (CYS)/H2S pathway stimulation causes cGMP-dependent relaxation of hum...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2bb758b82c57145a8a8ca11b62836b9
https://doi.org/10.1097/ju.0000000000000976.09

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