Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alejandro Rodríguez-Gama"'
Autor:
Michael J. Holliday, Axel Witt, Alejandro Rodríguez Gama, Benjamin T. Walters, Christopher P. Arthur, Randal Halfmann, Alexis Rohou, Erin C. Dueber, Wayne J. Fairbrother
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the struct
Externí odkaz:
https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b56
Autor:
Alejandro Rodríguez-Gama, Gerardo Gamba, Adrián Rafael Murillo-de-Ozores, Héctor Carbajal-Contreras, María Castañeda-Bueno
Publikováno v:
Am J Physiol Renal Physiol
With no lysine kinase-4 (WNK4) belongs to a serine-threonine kinase family characterized by the atypical positioning of its catalytic lysine. Despite the fact that WNK4 has been found in many tissues, the majority of its study has revolved around its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd3ca34aea2142b4007bbbaa4dd2e70
https://doi.org/10.1152/ajprenal.00634.2020
https://doi.org/10.1152/ajprenal.00634.2020
Autor:
Gerardo Gamba, Jesús García-Valdés, Eduardo R. Argaiz, Juliette Hadchouel, María Chávez-Canales, Norma Vázquez, David H. Ellison, Mauricio Ostrosky-Frid, Alejandro Rodríguez-Gama, Xochiquetzal Gonzalez-Rodriguez
Publikováno v:
American Journal of Physiology. Renal Physiology
American Journal of Physiology. Renal Physiology, 2018, 315 (3), pp.F734-F745. ⟨10.1152/ajprenal.00145.2018⟩
American Journal of Physiology. Renal Physiology, 2018, 315 (3), pp.F734-F745. ⟨10.1152/ajprenal.00145.2018⟩
Familial hyperkalemic hypertension (FHHt) can be mainly attributed to increased activity of the renal Na+:Cl−cotransporter (NCC), which is caused by altered expression and regulation of the with-no-lysine (K) 1 (WNK1) or WNK4 kinases. The WNK1 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbb573312aa0f49e1e92f1fd1cff79a
https://doi.org/10.1152/ajprenal.00145.2018
https://doi.org/10.1152/ajprenal.00145.2018
Autor:
Agnieszka Wengi, Junhui Zhang, María Castañeda-Bueno, Johannes Loffing, Richard P. Lifton, Alejandro Rodríguez-Gama, Diana Pacheco-Alvarez, Adrián Rafael Murillo-de-Ozores, David H. Ellison, Gerardo Gamba, Karla Leyva-Ríos, Silvana Bazúa-Valenti, Inti A. De La Rosa-Velázquez, Chao Ling Yang, Kathryn L. Stone, Norma Vázquez
Publikováno v:
Journal of Biological Chemistry. 293:12209-12221
WNK lysine-deficient protein kinase 4 (WNK4) is an important regulator of renal salt handling. Mutations in its gene cause pseudohypoaldosteronism type II, mainly arising from overactivation of the renal Na(+)/Cl(−) cotransporter (NCC). In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6b39c8c2682ac912482041633b9c78
https://doi.org/10.1074/jbc.ra118.003037
https://doi.org/10.1074/jbc.ra118.003037
Autor:
Andrew C. Box, Shriram Venkatesan, Randal Halfmann, Tejbir S. Kandola, Alejandro Rodríguez-Gama
Publikováno v:
J Vis Exp
Protein self-assembly governs protein function and compartmentalizes cellular processes in space and time. Current methods to study it suffer from low-sensitivity, indirect read-outs, limited throughput, and/or population-level rather than single-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbbcad6963dd066cd95fdc342b2294f
https://doi.org/10.3791/59577-v
https://doi.org/10.3791/59577-v
Autor:
Eduardo R. Argaiz, María Castañeda-Bueno, Gerardo Gamba, Diana Pacheco-Alvarez, Karla Leyva-Ríos, Alejandro Rodríguez-Gama, Christopher P. Cutler, Raquel Cariño-Cortés, Consuelo Plata, Adriana Mercado, León D. Islas, Norma Vázquez, Erika Moreno
Publikováno v:
Journal of Biological Chemistry. 291:22472-22481
The thiazide-sensitive Na-Cl cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian distal convoluted tubule. NCC plays a key role in the regulation of blood pressure. Its inhibition with thiazides constitutes the primary bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1890c8c540038afcecf52303836a1745
https://doi.org/10.1074/jbc.m116.742783
https://doi.org/10.1074/jbc.m116.742783
Autor:
Eduardo R. Argaiz, Lorena Rojas-Vega, Jesús García-Valdés, Consuelo Plata, Juliette Hadchouel, Norma Vázquez, María Chávez-Canales, Xochiquetzal Gonzalez-Rodriguez, David H. Ellison, Silvana Bazúa-Valenti, Gerardo Gamba, Alejandro Rodríguez-Gama
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269d32e6914a1b65da4d62f7a5efa5e8
https://doi.org/10.1096/fasebj.29.1_supplement.969.27
https://doi.org/10.1096/fasebj.29.1_supplement.969.27
Autor:
Eduardo R. Argaiz, Jesús García-Valdés, María Chávez-Canales, Juliette Hadchouel, Gerardo Gamba, David H. Ellison, Alejandro Rodríguez-Gama, Norma Vázquez, Zesergio Melo, Xochiquetzal Gonzalez-Rodriguez, Consuelo Plata, Silvana Bazúa-Valenti, Lorena Rojas-Vega
It is widely recognized that the phenotype of familial hyperkalemic hypertension is mainly a consequence of increased activity of the renal Na(+)-Cl(-) cotransporter (NCC) because of altered regulation by with no-lysine-kinase 1 (WNK1) or WNK4. The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa4cadbe5c825b21fd5bc73d697749a
https://europepmc.org/articles/PMC4520168/
https://europepmc.org/articles/PMC4520168/
